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Oscar osteoclast associated receptor [ Mus musculus (house mouse) ]

Gene ID: 232790, updated on 11-Nov-2024

Summary

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Official Symbol
Oscarprovided by MGI
Official Full Name
osteoclast associated receptorprovided by MGI
Primary source
MGI:MGI:2179720
See related
Ensembl:ENSMUSG00000054594 AllianceGenome:MGI:2179720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3
Summary
Enables collagen receptor activity. Acts upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface. Is expressed in testis. Orthologous to human OSCAR (osteoclast associated Ig-like receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 1.4), testis adult (RPKM 1.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Oscar in Genome Data Viewer
Location:
7 A1; 7 2.08 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3612812..3619156, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3609813..3616157, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35037 Neighboring gene predicted gene, 45920 Neighboring gene STARR-seq mESC enhancer starr_17907 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 Neighboring gene STARR-seq mESC enhancer starr_17908 Neighboring gene STARR-seq mESC enhancer starr_17909 Neighboring gene STARR-seq mESC enhancer starr_17910 Neighboring gene STARR-seq mESC enhancer starr_17911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:3581200-3581309 Neighboring gene STARR-positive B cell enhancer ABC_E2811 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene TCF3 (E2A) fusion partner

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation. Park DR, et al. Nat Commun, 2020 Aug 28. PMID 32859940, Free PMC Article
  2. Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression. So H, et al. J Biol Chem, 2003 Jun 27. PMID 12695521
  3. Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro. Sinningen K, et al. Biochem Biophys Res Commun, 2013 Jul 26. PMID 23817038
  4. Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis. Kim Y, et al. J Biol Chem, 2005 Sep 23. PMID 16046394
  5. Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation. Kim JH, et al. J Mol Biol, 2008 Nov 14. PMID 18762192

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
    Title: Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
  2. OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis
    Title: Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro.
  3. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.
    Title: OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
  4. Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.
    Title: Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
  5. OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis
    Title: Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
  6. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts
    Title: Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.
  7. the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation
    Title: Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).
  8. PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade.
    Title: Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.
  9. The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
    Title: Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables collagen receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Fc-gamma receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within interleukin-2 production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within interleukin-2 production IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within multinuclear osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
osteoclast-associated immunoglobulin-like receptor
Names
ocl178
osteoclast-associated receptor OSCAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290377.1 → NP_001277306.1  osteoclast-associated immunoglobulin-like receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001277306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF391159, AF391160
    Consensus CDS
    CCDS71872.1
    UniProtKB/Swiss-Prot
    Q8VBT3, Q8VHT9
    UniProtKB/TrEMBL
    B2RQ61
    Related
    ENSMUSP00000104285.2, ENSMUST00000108645.8
    Conserved Domains (1) summary
    cl11960
    Location:30 → 123
    Ig; Immunoglobulin domain

  2. NM_175632.3 → NP_783440.1  osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_783440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF391160, AF391161
    Consensus CDS
    CCDS20718.1
    UniProtKB/TrEMBL
    B2RQ61
    Related
    ENSMUSP00000041306.8, ENSMUST00000039507.15
    Conserved Domains (1) summary
    cl11960
    Location:36 → 129
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3612812..3619156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VBT3.1 GenPept UniProtKB/Swiss-Prot:Q8VBT3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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