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Zc3hc1 zinc finger, C3HC type 1 [ Mus musculus (house mouse) ]

Gene ID: 232679, updated on 2-Nov-2024

Summary

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Official Symbol
Zc3hc1provided by MGI
Official Full Name
zinc finger, C3HC type 1provided by MGI
Primary source
MGI:MGI:1916023
See related
Ensembl:ENSMUSG00000039130 AllianceGenome:MGI:1916023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nipa; HSPC216; 1110054L24Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in cell division and protein ubiquitination. Located in nucleus. Orthologous to human ZC3HC1 (zinc finger C3HC-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.9), CNS E18 (RPKM 10.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zc3hc1 in Genome Data Viewer
Location:
6 A3.3; 6 12.52 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30366383..30391019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30366384..30391049, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2H Neighboring gene STARR-seq mESC enhancer starr_15462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30250507-30250717 Neighboring gene RIKEN cDNA 1700095J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E4817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30290290-30290473 Neighboring gene STARR-seq mESC enhancer starr_15465 Neighboring gene STARR-positive B cell enhancer mm9_chr6:30307653-30307954 Neighboring gene STARR-positive B cell enhancer ABC_E6420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30351601-30351833 Neighboring gene kelch domain containing 10 Neighboring gene RIKEN cDNA 1700012C14 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure. Kreutmair S, et al. J Clin Invest, 2020 Jun 1. PMID 32338640, Free PMC Article
  2. Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase. Illert AL, et al. Development, 2012 Jul. PMID 22696294, Free PMC Article
  3. Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M. Illert AL, et al. J Biol Chem, 2012 Nov 2. PMID 22955283, Free PMC Article
  4. Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA). Ouyang T, et al. J Biol Chem, 2003 Aug 8. PMID 12748172
  5. APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1. Klitzing Cv, et al. PLoS One, 2011. PMID 22205987, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
    Title: Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
  2. Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2).
    Title: Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.
  3. Results reveal a novel role for NIPA in meiosis.
    Title: Targeted inactivation of nuclear interaction partner of ALK disrupts meiotic prophase.
  4. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner
    Title: APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.
  5. NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events
    Title: Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore nuclear basket IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger C3HC-type protein 1
Names
nuclear interacting partner of anaplastic lymphoma kinase (Alk)
nuclear-interacting partner of ALK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311086.1 → NP_001298015.1  zinc finger C3HC-type protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001298015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK151694, BC050141, BY235523
    Consensus CDS
    CCDS80508.1
    UniProtKB/Swiss-Prot
    Q3TJE6, Q80YV2, Q80Z11, Q8BTW5, Q8CI56, Q8R3U7
    UniProtKB/TrEMBL
    Q3TI64
    Related
    ENSMUSP00000079627.8, ENSMUST00000080812.14
    Conserved Domains (2) summary
    pfam07967
    Location:73 → 201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248 → 337
    Rsm1; Rsm1-like

  2. NM_172735.3 → NP_766323.1  zinc finger C3HC-type protein 1 isoform 2

    See identical proteins and their annotated locations for NP_766323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC155848, AC160148
    Consensus CDS
    CCDS19970.1
    UniProtKB/TrEMBL
    Q3TI64
    Related
    ENSMUSP00000100057.4, ENSMUST00000102992.10
    Conserved Domains (3) summary
    PTZ00449
    Location:302 → 476
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07967
    Location:73 → 201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248 → 337
    Rsm1; Rsm1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30366383..30391019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321571.3 → XP_017177060.1  zinc finger C3HC-type protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3TI64
    Conserved Domains (3) summary
    PTZ00449
    Location:302 → 476
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07967
    Location:73 → 201
    zf-C3HC; C3HC zinc finger-like
    pfam08600
    Location:248 → 337
    Rsm1; Rsm1-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YV2.1 GenPept UniProtKB/Swiss-Prot:Q80YV2

Gene LinkOut

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