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Ccdc136 coiled-coil domain containing 136 [ Mus musculus (house mouse) ]

Gene ID: 232664, updated on 10-Oct-2024

Summary

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Official Symbol
Ccdc136provided by MGI
Official Full Name
coiled-coil domain containing 136provided by MGI
Primary source
MGI:MGI:1918128
See related
Ensembl:ENSMUSG00000029769 AllianceGenome:MGI:1918128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921511K06Rik
Summary
Involved in acrosome assembly and single fertilization. Located in acrosomal membrane. Is expressed in retina outer nuclear layer. Orthologous to human CCDC136 (coiled-coil domain containing 136). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 86.4), cerebellum adult (RPKM 10.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc136 in Genome Data Viewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29396296..29426954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29396574..29426995)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calumenin Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Neighboring gene nuclear encoded tRNA proline 6 (anticodon AGG) Neighboring gene blue cone (S) opsin upstream regulatory region Neighboring gene filamin C, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr6:29417613-29417914 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice. Geng Q, et al. Reprod Sci, 2016 Oct. PMID 27076447
  2. Modeling of Photoreceptor Donor-Host Interaction Following Transplantation Reveals a Role for Crx, Müller Glia, and Rho/ROCK Signaling in Neurite Outgrowth. Tsai ELS, et al. Stem Cells, 2019 Apr. PMID 30715780
  3. InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes. Gurdita A, et al. iScience, 2021 Aug 20. PMID 34430805, Free PMC Article
  4. Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues. Ng L, et al. Front Endocrinol (Lausanne), 2023. PMID 37033230, Free PMC Article
  5. Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line. Smiley S, et al. Sci Rep, 2016 Mar 11. PMID 26965927, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 

General gene information

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Homology

Clone Names

  • MGC8047

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in acrosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acrosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in acrosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
coiled-coil domain-containing protein 136
Names
taraco

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201378.2 → NP_001188307.1  coiled-coil domain-containing protein 136 isoform 2

    See identical proteins and their annotated locations for NP_001188307.1

    Status: VALIDATED

    Source sequence(s)
    AC044807
    Consensus CDS
    CCDS59693.1
    UniProtKB/TrEMBL
    E6Y2W7
    Related
    ENSMUSP00000137747.2, ENSMUST00000180829.8
    Conserved Domains (2) summary
    pfam12018
    Location:61 → 206
    DUF3508; Domain of unknown function (DUF3508)
    cl23720
    Location:11 → 100
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_001347071.2 → NP_001334000.1  coiled-coil domain-containing protein 136 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC044807
    Consensus CDS
    CCDS85019.1
    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    UniProtKB/TrEMBL
    E9QP94
    Related
    ENSMUSP00000093789.6, ENSMUST00000096084.13

  3. NM_001347072.2 → NP_001334001.1  coiled-coil domain-containing protein 136 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC044807
    Consensus CDS
    CCDS85020.1
    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    UniProtKB/TrEMBL
    D3Z165
    Related
    ENSMUSP00000110930.2, ENSMUST00000115275.8

  4. NM_001347073.2 → NP_001334002.1  coiled-coil domain-containing protein 136 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC044807
    Consensus CDS
    CCDS85021.1
    UniProtKB/TrEMBL
    A0A0N4SW14
    Related
    ENSMUSP00000145331.2, ENSMUST00000145310.8
    Conserved Domains (1) summary
    COG1196
    Location:101 → 404
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. NM_001405562.1 → NP_001392491.1  coiled-coil domain-containing protein 136 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC044807

  6. NM_001405644.1 → NP_001392573.1  coiled-coil domain-containing protein 136 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC044807

  7. NM_001405645.1 → NP_001392574.1  coiled-coil domain-containing protein 136 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC044807

  8. NM_001405646.1 → NP_001392575.1  coiled-coil domain-containing protein 136 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC044807

  9. NM_001405647.1 → NP_001392576.1  coiled-coil domain-containing protein 136 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC044807

  10. NM_001405648.1 → NP_001392577.1  coiled-coil domain-containing protein 136 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC044807

  11. NM_001405649.1 → NP_001392578.1  coiled-coil domain-containing protein 136 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC044807

  12. NM_001405650.1 → NP_001392579.1  coiled-coil domain-containing protein 136 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC044807

  13. NM_001405651.1 → NP_001392580.1  coiled-coil domain-containing protein 136 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC044807

  14. NM_001405652.1 → NP_001392581.1  coiled-coil domain-containing protein 136 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC044807

  15. NM_001405653.1 → NP_001392582.1  coiled-coil domain-containing protein 136 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC044807

  16. NM_001405654.1 → NP_001392583.1  coiled-coil domain-containing protein 136 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC044807

  17. NM_001405655.1 → NP_001392584.1  coiled-coil domain-containing protein 136 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC044807

  18. NM_001405656.1 → NP_001392585.1  coiled-coil domain-containing protein 136 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC044807

  19. NM_001405657.1 → NP_001392586.1  coiled-coil domain-containing protein 136 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC044807

  20. NM_001405658.1 → NP_001392587.1  coiled-coil domain-containing protein 136 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC044807
    UniProtKB/TrEMBL
    A0A0N4SW14

  21. NM_001405659.1 → NP_001392588.1  coiled-coil domain-containing protein 136 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC044807

  22. NM_001405660.1 → NP_001392589.1  coiled-coil domain-containing protein 136 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC044807

  23. NM_145574.4 → NP_663549.3  coiled-coil domain-containing protein 136 isoform 1

    See identical proteins and their annotated locations for NP_663549.3

    Status: VALIDATED

    Source sequence(s)
    AC044807
    Consensus CDS
    CCDS51736.2
    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    UniProtKB/TrEMBL
    E6Y2W6
    Related
    ENSMUSP00000137673.2, ENSMUST00000181464.8
    Conserved Domains (2) summary
    pfam12018
    Location:61 → 206
    DUF3508; Domain of unknown function (DUF3508)
    cl23720
    Location:11 → 100
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29396296..29426954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166095.1 → XP_036021988.1  coiled-coil domain-containing protein 136 isoform X11

    Conserved Domains (2) summary
    COG1196
    Location:344 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:106 → 449
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006505056.5 → XP_006505119.1  coiled-coil domain-containing protein 136 isoform X13

    Conserved Domains (1) summary
    TIGR02168
    Location:106 → 449
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006505047.5 → XP_006505110.1  coiled-coil domain-containing protein 136 isoform X1

    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    Conserved Domains (2) summary
    COG1196
    Location:101 → 404
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:347 → 970
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_036166094.1 → XP_036021987.1  coiled-coil domain-containing protein 136 isoform X4

    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    Conserved Domains (1) summary
    COG1196
    Location:101 → 404
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_006505055.5 → XP_006505118.1  coiled-coil domain-containing protein 136 isoform X12

    Conserved Domains (2) summary
    COG1196
    Location:344 → 614
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:106 → 449
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_036166096.1 → XP_036021989.1  coiled-coil domain-containing protein 136 isoform X15

    Conserved Domains (1) summary
    COG1196
    Location:101 → 404
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006505052.4 → XP_006505115.1  coiled-coil domain-containing protein 136 isoform X6

    See identical proteins and their annotated locations for XP_006505115.1

    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    Conserved Domains (2) summary
    COG0419
    Location:153 → 793
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:106 → 449
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_006505053.4 → XP_006505116.1  coiled-coil domain-containing protein 136 isoform X7

    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    Conserved Domains (2) summary
    COG0419
    Location:153 → 793
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:106 → 449
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_006505048.4 → XP_006505111.1  coiled-coil domain-containing protein 136 isoform X3

    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    Conserved Domains (2) summary
    COG0419
    Location:153 → 793
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    TIGR02168
    Location:106 → 449
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_006505049.4 → XP_006505112.1  coiled-coil domain-containing protein 136 isoform X5

    UniProtKB/Swiss-Prot
    Q3TVA9, Q923E5
    UniProtKB/TrEMBL
    F6VCV9
    Related
    ENSMUSP00000118132.3, ENSMUST00000154619.5
    Conserved Domains (2) summary
    COG0419
    Location:8 → 635
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:3 → 317
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_001785125.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TVA9.2 GenPept UniProtKB/Swiss-Prot:Q3TVA9

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