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Klrb1f killer cell lectin-like receptor subfamily B member 1F [ Mus musculus (house mouse) ]

Gene ID: 232408, updated on 2-Nov-2024

Summary

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Official Symbol
Klrb1fprovided by MGI
Official Full Name
killer cell lectin-like receptor subfamily B member 1Fprovided by MGI
Primary source
MGI:MGI:2442965
See related
Ensembl:ENSMUSG00000030154 AllianceGenome:MGI:2442965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkrp1f; Nkr-p1f; Nkrp1-f; A630024B12Rik
Summary
Enables signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Located in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Klrb1f in Genome Data Viewer
Location:
6 F3; 6 63.12 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129022800..129036687)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129045837..129059724)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC064078 Neighboring gene C-type lectin domain family 2, member f Neighboring gene STARR-seq mESC enhancer starr_17472 Neighboring gene STARR-seq mESC enhancer starr_17473 Neighboring gene STARR-seq mESC enhancer starr_17475 Neighboring gene C-type lectin domain family 2, member e Neighboring gene killer cell lectin-like receptor subfamily B member 1, pseudogene 1 Neighboring gene predicted gene, 53342

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing OCILRP2 leads to intrinsic defects in T cells in response to antigenic stimulation. Tian W, et al. Cell Immunol, 2005 May. PMID 16143319
  2. Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F: crystal structure and biophysical properties. Skálová T, et al. J Immunol, 2012 Nov 15. PMID 23071282
  3. Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells. Adámková L, et al. Int J Mol Sci, 2019 Apr 16. PMID 30995786, Free PMC Article
  4. C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Tian W, et al. Cell Immunol, 2005 Mar. PMID 15963483
  5. Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f. Plougastel B, et al. Immunogenetics, 2001 Sep. PMID 11685472

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface.
    Title: Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
  2. The electrostatic profile of NKR-P1F is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential.
    Title: Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F: crystal structure and biophysical properties.
  3. studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo
    Title: C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC130065, MGC130066

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily B member 1F
Names
CD161 antigen-like family member F
natural killer cell surface protein NKR-P1F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153094.2 → NP_694734.1  killer cell lectin-like receptor subfamily B member 1F

    See identical proteins and their annotated locations for NP_694734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and is protein-coding.
    Source sequence(s)
    AK041601, AK042352, BC127142
    Consensus CDS
    CCDS20579.1
    UniProtKB/Swiss-Prot
    Q1AFZ8, Q3TDT3, Q8C9Q1, Q8VD98
    UniProtKB/TrEMBL
    G4WMX8, I3QI43
    Related
    ENSMUSP00000032257.8, ENSMUST00000032257.10
    Conserved Domains (1) summary
    cd03593
    Location:94 → 212
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RNA

  1. NR_024262.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it is a nonsense-mediated mRNA decay (NMD) candidate when the 5'-most translation start codon is used, as in variant 1.
    Source sequence(s)
    AK041601, AK042352, BC127141
    Related
    ENSMUST00000203059.3

  2. NR_024263.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because it is a nonsense-mediated mRNA decay (NMD) candidate when the 5'-most translation start codon is used, as in variant 1.
    Source sequence(s)
    AK041601, AK042352, BC107178

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129022800..129036687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321558.1 → XP_017177047.1  killer cell lectin-like receptor subfamily B member 1F isoform X1

    UniProtKB/TrEMBL
    G4WMX8
    Conserved Domains (1) summary
    cd03593
    Location:69 → 187
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. XM_006506036.4 → XP_006506099.1  killer cell lectin-like receptor subfamily B member 1F isoform X2

    Conserved Domains (1) summary
    cd03593
    Location:71 → 170
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VD98.1 GenPept UniProtKB/Swiss-Prot:Q8VD98

Gene LinkOut

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