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RHOBTB2 Rho related BTB domain containing 2 [ Homo sapiens (human) ]

Gene ID: 23221, updated on 3-Apr-2024

Summary

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Official Symbol
RHOBTB2provided by HGNC
Official Full Name
Rho related BTB domain containing 2provided by HGNC
Primary source
HGNC:HGNC:18756
See related
Ensembl:ENSG00000008853 MIM:607352; AllianceGenome:HGNC:18756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p83; DBC2; DEE64; EIEE64
Summary
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in lung (RPKM 11.1), brain (RPKM 8.7) and 22 other tissues See more
Orthologs
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Genomic context

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See RHOBTB2 in Genome Data Viewer
Location:
8p21.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22950813..23020199)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (23225786..23295160)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22844764..22877712)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 4 Neighboring gene uncharacterized LOC101929237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27097 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22744265-22744765 Neighboring gene uncharacterized LOC124901907 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22760306-22760493 Neighboring gene Sharpr-MPRA regulatory region 3596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769137-22769908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22769909-22770680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22777059-22777987 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22809645-22810276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22810277-22810907 Neighboring gene uncharacterized LOC107984124 Neighboring gene NANOG hESC enhancer GRCh37_chr8:22814761-22815262 Neighboring gene VISTA enhancer hs1927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22845205-22845961 Neighboring gene RNA, 7SL, cytoplasmic 303, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861268-22861793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22861794-22862318 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:22866186-22866771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22871840-22872604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27102 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:22876025-22876192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22876488-22877052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22877053-22877615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22885758-22886258 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:22886259-22886759 Neighboring gene TNF receptor superfamily member 10b Neighboring gene Sharpr-MPRA regulatory region 6582 Neighboring gene TNFRSF10B antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:22921484-22922683 Neighboring gene TNFRSF10B 5' regulatory region Neighboring gene Sharpr-MPRA regulatory region 12406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22928365-22928864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:22941919-22942800 Neighboring gene uncharacterized LOC254896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:22960499-22961308 Neighboring gene TNF receptor superfamily member 10c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mild head trauma: Acute encephalopathy trigger in children with RHOBTB2 de novo mutation. Jové Blanco A, et al. Neurologia (Engl Ed), 2022 Oct. PMID 36195378
  2. Identification of RHOBTB2 aberration as an independent prognostic indicator in acute myeloid leukemia. Liu P, et al. Aging (Albany NY), 2021 Jun 1. PMID 34074803, Free PMC Article
  3. RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood. Zagaglia S, et al. Neurology, 2021 Mar 16. PMID 33504645, Free PMC Article
  4. The mutation of DBC2 in breast cancer patients from the Han ethnic group in Eastern China. Fu G, et al. Hematol Oncol Stem Cell Ther, 2014 Jun. PMID 24485767
  5. RhoBTB2 gene in breast cancer is silenced by promoter methylation. Tang W, et al. Int J Mol Med, 2014 Mar. PMID 24356943

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders.
    Title: Genotype-phenotype correlations in RHOBTB2-associated neurodevelopmental disorders.
  2. Mild head trauma: Acute encephalopathy trigger in children with RHOBTB2 de novo mutation.
    Title: Mild head trauma: Acute encephalopathy trigger in children with RHOBTB2 de novo mutation.
  3. Identification of RHOBTB2 aberration as an independent prognostic indicator in acute myeloid leukemia.
    Title: Identification of RHOBTB2 aberration as an independent prognostic indicator in acute myeloid leukemia.
  4. RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood.
    Title: RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood.
  5. missense variants in the BTB-domain-encoding region of RHOBTB2 as causative for a developmental and epileptic encephalopathy.
    Title: Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
  6. these findings provide evidence that DBC2 suppresses tumorigenesis in breast cancer by ubiquitinating MSI2.
    Title: DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer.
  7. Mutation in the promoter and exon 7 of DBC2 gene is not common in the Chinese population and may not contribute to the susceptibility for breast cancer in China
    Title: The mutation of DBC2 in breast cancer patients from the Han ethnic group in Eastern China.
  8. data suggest a new paradigm for Hsp90-modulated assembly of a Cul3/DBC2 E3 ubiquitin ligase complex that may extend to other E3 ligase complexes.
    Title: Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.
  9. ). The results demonstrated that aberrant methylation of RhoBTB2 may be responsible for the suppression of RhoBTB2 mRNA expression in breast cancer, a significant event during the genesis of breast cancer that correlated with progesterone receptor status
    Title: RhoBTB2 gene in breast cancer is silenced by promoter methylation.
  10. Thus loss of DBC2 expression is caused by abnormal methylation of DBC2 and might have a role in breast cancer development.
    Title: Decreased expression of the DBC2 gene and its clinicopathological significance in breast cancer: correlation with aberrant DNA methylation.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 64
MedGen: C4693899 OMIM: 618004 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endosome membrane TAS
Traceable Author Statement
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related BTB domain-containing protein 2
Names
deleted in breast cancer 2 gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047133.2 RefSeqGene

    Range
    53737..74388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160036.2 → NP_001153508.1  rho-related BTB domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001153508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA641575, AB018260, AC107959, AK292863, AY009093, BC034917, BG255120
    Consensus CDS
    CCDS55210.1
    UniProtKB/TrEMBL
    A0A8I5KV41
    Related
    ENSP00000427926.1, ENST00000519685.5
    Conserved Domains (5) summary
    cd01873
    Location:35 → 229
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:39 → 230
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:523 → 615
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:513 → 615
    BTB; BTB/POZ domain
    cl02518
    Location:443 → 490
    BTB; BTB/POZ domain

  2. NM_001160037.2 → NP_001153509.1  rho-related BTB domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC107959
    Consensus CDS
    CCDS55211.1
    UniProtKB/TrEMBL
    A0A8I5KV41
    Related
    ENSP00000429141.1, ENST00000522948.5
    Conserved Domains (5) summary
    cd01873
    Location:20 → 214
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:24 → 215
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:508 → 600
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:498 → 600
    BTB; BTB/POZ domain
    cl02518
    Location:428 → 475
    BTB; BTB/POZ domain

  3. NM_001374791.1 → NP_001361720.1  rho-related BTB domain-containing protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC107959
    Consensus CDS
    CCDS6034.1
    UniProtKB/Swiss-Prot
    A8K9Z8, D3DSR8, E9PBU2, E9PEI7, O94825, Q8N4A8, Q9BYZ6, Q9BZK6
    UniProtKB/TrEMBL
    A0A8I5KV41
    Related
    ENSP00000509630.1, ENST00000692529.1
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18356
    Location:250 → 475
    BTB1_POZ_RHOBTB2; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18359
    Location:480 → 603
    BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18531
    Location:608 → 704
    BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)

  4. NM_015178.3 → NP_055993.2  rho-related BTB domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_055993.2

    Status: REVIEWED

    Source sequence(s)
    AC107959
    Consensus CDS
    CCDS6034.1
    UniProtKB/Swiss-Prot
    A8K9Z8, D3DSR8, E9PBU2, E9PEI7, O94825, Q8N4A8, Q9BYZ6, Q9BZK6
    UniProtKB/TrEMBL
    A0A8I5KV41
    Related
    ENSP00000251822.7, ENST00000251822.7
    Conserved Domains (4) summary
    cd01873
    Location:13 → 207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    cd18356
    Location:250 → 475
    BTB1_POZ_RHOBTB2; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18359
    Location:480 → 603
    BTB2_POZ_RHOBTB2; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)
    cd18531
    Location:608 → 704
    BACK_RHOBTB2; BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22950813..23020199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421609.1 → XP_047277565.1  rho-related BTB domain-containing protein 2 isoform X1

  2. XM_047421611.1 → XP_047277567.1  rho-related BTB domain-containing protein 2 isoform X1

  3. XM_047421610.1 → XP_047277566.1  rho-related BTB domain-containing protein 2 isoform X1

  4. XM_047421607.1 → XP_047277563.1  rho-related BTB domain-containing protein 2 isoform X1

  5. XM_047421608.1 → XP_047277564.1  rho-related BTB domain-containing protein 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    23225786..23295160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360181.1 → XP_054216156.1  rho-related BTB domain-containing protein 2 isoform X1

  2. XM_054360183.1 → XP_054216158.1  rho-related BTB domain-containing protein 2 isoform X1

  3. XM_054360182.1 → XP_054216157.1  rho-related BTB domain-containing protein 2 isoform X1

  4. XM_054360179.1 → XP_054216154.1  rho-related BTB domain-containing protein 2 isoform X1

  5. XM_054360180.1 → XP_054216155.1  rho-related BTB domain-containing protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYZ6.2 GenPept UniProtKB/Swiss-Prot:Q9BYZ6

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