U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ATP11B ATPase phospholipid transporting 11B (putative) [ Homo sapiens (human) ]

Gene ID: 23200, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ATP11Bprovided by HGNC
Official Full Name
ATPase phospholipid transporting 11B (putative)provided by HGNC
Primary source
HGNC:HGNC:13553
See related
Ensembl:ENSG00000058063 MIM:605869; AllianceGenome:HGNC:13553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPIF; ATPIR
Summary
P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
Expression
Ubiquitous expression in esophagus (RPKM 12.0), bone marrow (RPKM 11.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q26.33
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (182793504..182921629)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (185598610..185726735)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182511292..182639417)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986054 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5107 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20882 Neighboring gene MPRA-validated peak4955 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14932 Neighboring gene ATP11B divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182516660-182517160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182517161-182517661 Neighboring gene Sharpr-MPRA regulatory region 857 Neighboring gene EIF3E pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20883 Neighboring gene defective in cullin neddylation 1 domain containing 1 Neighboring gene C9orf85 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14935 Neighboring gene uncharacterized LOC105374246

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic analysis of the ATP11B gene in Chinese Han population with cerebral small vessel disease. Yu WK, et al. BMC Genomics, 2022 Dec 12. PMID 36510145, Free PMC Article
  2. ATP11B mediates platinum resistance in ovarian cancer. Moreno-Smith M, et al. J Clin Invest, 2013 May. PMID 23585472, Free PMC Article
  3. Reanalysis of ATP11B, a type IV P-type ATPase. Halleck MS, et al. J Biol Chem, 2002 Mar 22. PMID 11790799
  4. ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum. Tone T, et al. FEBS Lett, 2020 Feb. PMID 31571211
  5. Discovery of tissue-specific exons using comprehensive human exon microarrays. Clark TA, et al. Genome Biol, 2007. PMID 17456239, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0956, MGC46576, DKFZp434J238, DKFZp434N1615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion transmembrane transporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables phosphatidylethanolamine flippase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine floppase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aminophospholipid transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in monoatomic ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in monoatomic ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nuclear inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of phospholipid-translocating ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phospholipid-transporting ATPase IF
Names
ATPase IR
ATPase, class VI, type 11B
P4-ATPase flippase complex alpha subunit ATP11B
probable phospholipid-transporting ATPase IF
NP_055431.1
XP_011510895.1
XP_011510896.1
XP_011510899.1
XP_016861497.1
XP_047303740.1
XP_054201806.1
XP_054201807.1
XP_054201808.1
XP_054201809.1
XP_054201810.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014616.3 → NP_055431.1  phospholipid-transporting ATPase IF

    See identical proteins and their annotated locations for NP_055431.1

    Status: VALIDATED

    Source sequence(s)
    AB023173, AF156548, AK296750, AK304855, AL133061, BI861412, BX489704, DR000074
    Consensus CDS
    CCDS33896.1
    UniProtKB/Swiss-Prot
    Q96FN1, Q9UKK7, Q9Y2G3
    Related
    ENSP00000321195.5, ENST00000323116.10
    Conserved Domains (6) summary
    TIGR01652
    Location:39 → 1106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96 → 180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494 → 605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:35 → 89
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:847 → 1100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629 → 868
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    182793504..182921629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447784.1 → XP_047303740.1  phospholipid-transporting ATPase IF isoform X1

  2. XM_011512593.3 → XP_011510895.1  phospholipid-transporting ATPase IF isoform X2

    UniProtKB/TrEMBL
    H7C4W6
    Conserved Domains (6) summary
    TIGR01652
    Location:39 → 1106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96 → 180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494 → 605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:35 → 89
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:847 → 1100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629 → 868
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. XM_011512594.3 → XP_011510896.1  phospholipid-transporting ATPase IF isoform X3

    Conserved Domains (6) summary
    TIGR01652
    Location:39 → 1106
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:96 → 180
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:494 → 605
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:35 → 89
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:847 → 1100
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:629 → 868
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. XM_011512597.3 → XP_011510899.1  phospholipid-transporting ATPase IF isoform X4

    UniProtKB/TrEMBL
    B4E3T1
    Related
    ENSP00000418421.1, ENST00000498086.5
    Conserved Domains (3) summary
    pfam13246
    Location:274 → 385
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:627 → 880
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:409 → 648
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  5. XM_017006008.2 → XP_016861497.1  phospholipid-transporting ATPase IF isoform X5

    UniProtKB/TrEMBL
    B4E3T1
    Conserved Domains (3) summary
    pfam13246
    Location:175 → 286
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16212
    Location:528 → 781
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:310 → 549
    HAD_like; Haloacid Dehalogenase-like Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    185598610..185726735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345831.1 → XP_054201806.1  phospholipid-transporting ATPase IF isoform X1

  2. XM_054345832.1 → XP_054201807.1  phospholipid-transporting ATPase IF isoform X2

  3. XM_054345833.1 → XP_054201808.1  phospholipid-transporting ATPase IF isoform X3

  4. XM_054345834.1 → XP_054201809.1  phospholipid-transporting ATPase IF isoform X4

  5. XM_054345835.1 → XP_054201810.1  phospholipid-transporting ATPase IF isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2G3.2 GenPept UniProtKB/Swiss-Prot:Q9Y2G3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous