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Radil Ras association and DIL domains [ Mus musculus (house mouse) ]

Gene ID: 231858, updated on 28-Oct-2024

Summary

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Official Symbol
Radilprovided by MGI
Official Full Name
Ras association and DIL domainsprovided by MGI
Primary source
MGI:MGI:2443088
See related
Ensembl:ENSMUSG00000029576 AllianceGenome:MGI:2443088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930005D10Rik
Summary
Predicted to enable GTPase binding activity. Predicted to be involved in neural crest cell migration and substrate adhesion-dependent cell spreading. Predicted to be part of protein-containing complex. Predicted to be active in microtubule. Is expressed in testis. Orthologous to human RADIL (Rap associating with DIL domain). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 12.8), lung adult (RPKM 12.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Radil in Genome Data Viewer
Location:
5 G2; 5 81.53 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142470594..142536873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142483795..142551098, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene forkhead box K1 Neighboring gene predicted gene, 54310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:142915875-142916058 Neighboring gene STARR-positive B cell enhancer ABC_E4804 Neighboring gene STARR-positive B cell enhancer ABC_E2771 Neighboring gene STARR-seq mESC enhancer starr_14747 Neighboring gene adaptor-related protein complex 5, zeta 1 subunit Neighboring gene predicted gene, 38732 Neighboring gene poly (A) polymerase beta (testis specific) Neighboring gene STARR-positive B cell enhancer ABC_E8090 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene predicted gene, 31274

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Uncovering gene regulatory networks during mouse fetal germ cell development. Rolland AD, et al. Biol Reprod, 2011 Apr. PMID 21148109, Free PMC Article
  2. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Smolen GA, et al. Genes Dev, 2007 Sep 1. PMID 17704304, Free PMC Article
  3. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-associating and dilute domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289588.1 → NP_001276517.1  ras-associating and dilute domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001276517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI536456, AK162917, BY201066
    Consensus CDS
    CCDS71698.1
    UniProtKB/TrEMBL
    D3YWJ9
    Related
    ENSMUSP00000106412.2, ENSMUST00000110785.2
    Conserved Domains (4) summary
    cd00992
    Location:992 → 1076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:411 → 778
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cd17116
    Location:50 → 161
    RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
    pfam00498
    Location:273 → 343
    FHA; FHA domain

  2. NM_001310752.1 → NP_001297681.1  ras-associating and dilute domain-containing protein isoform 3

    See identical proteins and their annotated locations for NP_001297681.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AI536456, AK052964, AK083410
    Consensus CDS
    CCDS80453.1
    UniProtKB/Swiss-Prot
    Q69Z89, Q8BNL0, Q8C549, Q8C6X2, Q8CAL1
    Related
    ENSMUSP00000082910.4, ENSMUST00000085758.10
    Conserved Domains (4) summary
    cd00992
    Location:998 → 1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:440 → 807
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:302 → 372
    FHA; FHA domain
    pfam00788
    Location:90 → 193
    RA; Ras association (RalGDS/AF-6) domain

  3. NM_178702.4 → NP_848817.2  ras-associating and dilute domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_848817.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site inthe 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI536456, BC056483, BY201066
    Consensus CDS
    CCDS19827.1
    UniProtKB/Swiss-Prot
    Q69Z89
    Related
    ENSMUSP00000064539.9, ENSMUST00000063635.15
    Conserved Domains (4) summary
    cd00992
    Location:969 → 1053
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:411 → 778
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:273 → 343
    FHA; FHA domain
    pfam00788
    Location:61 → 164
    RA; Ras association (RalGDS/AF-6) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142470594..142536873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504685.5 → XP_006504748.1  ras-associating and dilute domain-containing protein isoform X2

    See identical proteins and their annotated locations for XP_006504748.1

    UniProtKB/TrEMBL
    D3YWJ9
    Conserved Domains (4) summary
    cd00992
    Location:992 → 1076
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:411 → 778
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cd17116
    Location:50 → 161
    RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
    pfam00498
    Location:273 → 343
    FHA; FHA domain

  2. XM_006504682.4 → XP_006504745.1  ras-associating and dilute domain-containing protein isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:1021 → 1105
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:440 → 807
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    cd17116
    Location:79 → 190
    RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
    pfam00498
    Location:302 → 372
    FHA; FHA domain

  3. XM_030254449.2 → XP_030110309.1  ras-associating and dilute domain-containing protein isoform X5

    Conserved Domains (2) summary
    cd00992
    Location:475 → 559
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:1 → 284
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1

  4. XM_030254445.2 → XP_030110305.1  ras-associating and dilute domain-containing protein isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:752 → 836
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171 → 538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33 → 103
    FHA; FHA domain

  5. XM_030254446.2 → XP_030110306.1  ras-associating and dilute domain-containing protein isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:752 → 836
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171 → 538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33 → 103
    FHA; FHA domain

  6. XM_006504686.4 → XP_006504749.1  ras-associating and dilute domain-containing protein isoform X4

    See identical proteins and their annotated locations for XP_006504749.1

    UniProtKB/Swiss-Prot
    Q69Z89
    Related
    ENSMUSP00000106411.2, ENSMUST00000110784.8
    Conserved Domains (3) summary
    cd00992
    Location:729 → 813
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171 → 538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33 → 103
    FHA; FHA domain

  7. XM_030254447.2 → XP_030110307.1  ras-associating and dilute domain-containing protein isoform X4

    Conserved Domains (3) summary
    cd00992
    Location:729 → 813
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171 → 538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33 → 103
    FHA; FHA domain

  8. XM_030254444.2 → XP_030110304.1  ras-associating and dilute domain-containing protein isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:752 → 836
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd15472
    Location:171 → 538
    Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    pfam00498
    Location:33 → 103
    FHA; FHA domain

RNA

  1. XR_004942508.1 RNA Sequence

    Related
    ENSMUST00000139824.2

  2. XR_001784688.3 RNA Sequence

  3. XR_377156.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69Z89.2 GenPept UniProtKB/Swiss-Prot:Q69Z89

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