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Tmem184a transmembrane protein 184a [ Mus musculus (house mouse) ]

Gene ID: 231832, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem184aprovided by MGI
Official Full Name
transmembrane protein 184aprovided by MGI
Primary source
MGI:MGI:2385897
See related
Ensembl:ENSMUSG00000036687 AllianceGenome:MGI:2385897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sdmg1
Summary
Predicted to enable heparin binding activity and transmembrane transporter activity. Acts upstream of or within germ-line sex determination; regulation of protein localization; and regulation of secretion. Located in early endosome membrane and secretory granule membrane. Is expressed in several structures, including exocrine gland; gonad; gut; lung; and nose. Orthologous to human TMEM184A (transmembrane protein 184A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum adult (RPKM 77.6), stomach adult (RPKM 73.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem184a in Genome Data Viewer
Location:
5 G2; 5 78.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139790707..139805725, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139804951..139819969, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 1 Neighboring gene microRNA 7037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140252978-140253165 Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene proteasome (prosome, macropain) assembly chaperone 3 Neighboring gene predicted gene, 38727

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Svingen T, et al. Reproduction, 2007 May. PMID 17616727
  2. Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues. Best D, et al. Dev Dyn, 2009 Jan. PMID 19097053
  3. Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice. Auguste A, et al. Sex Dev, 2011. PMID 22116255
  4. XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. Lavery R, et al. Dev Biol, 2011 Jun 1. PMID 21466799
  5. Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Nef S, et al. Dev Biol, 2005 Nov 15. PMID 16214126

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC30809, MGC37596

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within germ-line sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 184A
Names
sexually dimorphic expressed in male gonads 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161548.1 → NP_001155020.1  transmembrane protein 184A isoform 1

    See identical proteins and their annotated locations for NP_001155020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK050489, AK148454, CJ159994
    Consensus CDS
    CCDS51685.1
    UniProtKB/TrEMBL
    G3X923
    Related
    ENSMUSP00000035399.5, ENSMUST00000044002.10
    Conserved Domains (1) summary
    pfam03619
    Location:82 → 352
    Solute_trans_a; Organic solute transporter Ostalpha

  2. NM_144914.3 → NP_659163.3  transmembrane protein 184A isoform 2

    See identical proteins and their annotated locations for NP_659163.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK148454, BY230075
    Consensus CDS
    CCDS39354.1
    UniProtKB/Swiss-Prot
    Q3UFJ6, Q8BII8, Q8K1B0
    Related
    ENSMUSP00000106456.2, ENSMUST00000110832.8
    Conserved Domains (1) summary
    pfam03619
    Location:61 → 330
    Solute_trans_a; Organic solute transporter Ostalpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139790707..139805725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504670.5 → XP_006504733.1  transmembrane protein 184A isoform X1

    See identical proteins and their annotated locations for XP_006504733.1

    UniProtKB/Swiss-Prot
    Q3UFJ6, Q8BII8, Q8K1B0
    Conserved Domains (1) summary
    pfam03619
    Location:61 → 330
    Solute_trans_a; Organic solute transporter Ostalpha

  2. XM_006504671.3 → XP_006504734.1  transmembrane protein 184A isoform X1

    See identical proteins and their annotated locations for XP_006504734.1

    UniProtKB/Swiss-Prot
    Q3UFJ6, Q8BII8, Q8K1B0
    Conserved Domains (1) summary
    pfam03619
    Location:61 → 330
    Solute_trans_a; Organic solute transporter Ostalpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UFJ6.1 GenPept UniProtKB/Swiss-Prot:Q3UFJ6

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