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Paqr3 progestin and adipoQ receptor family member III [ Mus musculus (house mouse) ]

Gene ID: 231474, updated on 28-Oct-2024

Summary

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Official Symbol
Paqr3provided by MGI
Official Full Name
progestin and adipoQ receptor family member IIIprovided by MGI
Primary source
MGI:MGI:2679683
See related
Ensembl:ENSMUSG00000055725 AllianceGenome:MGI:2679683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RKTG; 6330415A20Rik
Summary
Predicted to enable signaling receptor activity. Acts upstream of or within negative regulation of MAP kinase activity. Predicted to be located in Golgi apparatus. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 5.7), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Paqr3 in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (97229223..97259608, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (97081364..97111749, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46916 Neighboring gene STARR-positive B cell enhancer ABC_E11294 Neighboring gene STARR-seq mESC enhancer starr_13683 Neighboring gene STARR-positive B cell enhancer ABC_E1303 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:97425959-97426223 Neighboring gene predicted gene 9484 Neighboring gene BMP2 inducible kinase Neighboring gene STARR-positive B cell enhancer ABC_E3589 Neighboring gene STARR-seq mESC enhancer starr_13685 Neighboring gene STARR-seq mESC enhancer starr_13686 Neighboring gene STARR-positive B cell enhancer mm9_chr5:97540551-97540852 Neighboring gene predicted gene, 33609 Neighboring gene STARR-seq mESC enhancer starr_13687 Neighboring gene predicted gene 2861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells. Qiao S, et al. Life Sci, 2021 Jan 15. PMID 33249098
  2. Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse. Xie X, et al. Carcinogenesis, 2008 Aug. PMID 18550569
  3. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Wang X, et al. Diabetes, 2013 Feb. PMID 23086038, Free PMC Article
  4. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Jiang Y, et al. Cancer Res, 2011 Apr 15. PMID 21385899
  5. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Wang L, et al. Endocrinology, 2013 Dec. PMID 24035996

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
    Title: Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
  2. PAQR3 plays a pivotal role in controlling hepatic LDLR degradation and blood LDL-C level via modulating LDLR-PCSK9 interaction.
    Title: PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9.
  3. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
    Title: PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.
  4. PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.
    Title: PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
  5. This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling.
    Title: PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling.
  6. PAQR3 negatively regulates insulin signaling by shunting cytosolic p110alpha to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110alpha.
    Title: PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.
  7. Loss of PAQR3 is associated with tumorigenesis of colorectal cancers.
    Title: PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.
  8. reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway.
    Title: Spatial regulation of Raf kinase signaling by RKTG.
  9. RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin.
    Title: Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
progestin and adipoQ receptor family member 3
Names
Raf kinase trapping to Golgi

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359910.2 → NP_001346839.1  progestin and adipoQ receptor family member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125229
    Consensus CDS
    CCDS19451.1
    UniProtKB/Swiss-Prot
    Q6TCG8
    UniProtKB/TrEMBL
    Q0VAZ2, Q3UEZ4
    Related
    ENSMUSP00000108593.4, ENSMUST00000112969.10
    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

  2. NM_001359913.2 → NP_001346842.1  progestin and adipoQ receptor family member 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC125229
    Consensus CDS
    CCDS89954.1
    UniProtKB/TrEMBL
    D3Z181
    Related
    ENSMUSP00000108592.2, ENSMUST00000112968.2
    Conserved Domains (1) summary
    cl03831
    Location:64 → 170
    HlyIII; Haemolysin-III related

  3. NM_001428771.1 → NP_001415700.1  progestin and adipoQ receptor family member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125229
    UniProtKB/Swiss-Prot
    Q6TCG8
    UniProtKB/TrEMBL
    Q0VAZ2

  4. NM_001428772.1 → NP_001415701.1  progestin and adipoQ receptor family member 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC125229
    UniProtKB/Swiss-Prot
    Q6TCG8
    UniProtKB/TrEMBL
    Q0VAZ2

  5. NM_001428773.1 → NP_001415702.1  progestin and adipoQ receptor family member 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC125229

  6. NM_001428774.1 → NP_001415703.1  progestin and adipoQ receptor family member 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC125229

  7. NM_001428775.1 → NP_001415704.1  progestin and adipoQ receptor family member 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC125229

  8. NM_001428776.1 → NP_001415705.1  progestin and adipoQ receptor family member 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC125229

  9. NM_198422.4 → NP_940814.1  progestin and adipoQ receptor family member 3 isoform a

    See identical proteins and their annotated locations for NP_940814.1

    Status: VALIDATED

    Source sequence(s)
    AC125229
    Consensus CDS
    CCDS19451.1
    UniProtKB/Swiss-Prot
    Q6TCG8
    UniProtKB/TrEMBL
    Q0VAZ2, Q3UEZ4
    Related
    ENSMUSP00000069324.3, ENSMUST00000069453.9
    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    97229223..97259608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165068.1 → XP_036020961.1  progestin and adipoQ receptor family member 3 isoform X3

    Conserved Domains (1) summary
    cl03831
    Location:64 → 217
    HlyIII; Haemolysin-III related

  2. XM_006534876.4 → XP_006534939.1  progestin and adipoQ receptor family member 3 isoform X2

    Conserved Domains (1) summary
    cl03831
    Location:64 → 262
    HlyIII; Haemolysin-III related

  3. XM_006534875.5 → XP_006534938.1  progestin and adipoQ receptor family member 3 isoform X1

    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

  4. XM_036165067.1 → XP_036020960.1  progestin and adipoQ receptor family member 3 isoform X2

    Conserved Domains (1) summary
    cl03831
    Location:64 → 262
    HlyIII; Haemolysin-III related
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TCG8.1 GenPept UniProtKB/Swiss-Prot:Q6TCG8

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