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Grsf1 G-rich RNA sequence binding factor 1 [ Mus musculus (house mouse) ]

Gene ID: 231413, updated on 28-Oct-2024

Summary

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Official Symbol
Grsf1provided by MGI
Official Full Name
G-rich RNA sequence binding factor 1provided by MGI
Primary source
MGI:MGI:106479
See related
Ensembl:ENSMUSG00000044221 AllianceGenome:MGI:106479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Wsu31e
Summary
Predicted to enable RNA binding activity. Acts upstream of or within anterior/posterior pattern specification and morphogenesis of embryonic epithelium. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human GRSF1 (G-rich RNA sequence binding factor 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 66.8), ovary adult (RPKM 32.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Grsf1 in Genome Data Viewer
Location:
5 E1; 5 43.85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88807092..88824030, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88659233..88676171, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2748 Neighboring gene UTP3 small subunit processome component Neighboring gene predicted gene, 42107 Neighboring gene RUN and FYVE domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_13573 Neighboring gene STARR-seq mESC enhancer starr_13574 Neighboring gene STARR-seq mESC enhancer starr_13575 Neighboring gene STARR-seq mESC enhancer starr_13576 Neighboring gene STARR-seq mESC enhancer starr_13577 Neighboring gene MOB kinase activator 1B Neighboring gene predicted gene 15682 Neighboring gene STARR-positive B cell enhancer ABC_E1682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:89195274-89195480 Neighboring gene deoxycytidine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1(-/-)) gain less body weight during adolescence and adulthood. Dumoulin B, et al. Cell Biosci, 2022 Dec 9. PMID 36494688, Free PMC Article
  2. Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production. Yin W, et al. Exp Cell Res, 2019 Aug 1. PMID 31085189
  3. Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis. Li Y, et al. Mol Neurobiol, 2024 Apr. PMID 37861894
  4. Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development. Ufer C, et al. Genes Dev, 2008 Jul 1. PMID 18593884, Free PMC Article
  5. GRSF1 is an age-related regulator of senescence. Kim SJ, et al. Sci Rep, 2019 Apr 3. PMID 30944385, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.
    Title: Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.
  2. GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.
    Title: GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.
  3. GRSF1 is an age-related regulator of senescence.
    Title: GRSF1 is an age-related regulator of senescence.
  4. GRSF1 has a negative role in muscle differentiation
    Title: Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production.
  5. Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site.
    Title: Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
  6. Grsf1 up-regulates translation of GPx4 mRNA and implicate the two proteins in embryonic brain development.
    Title: Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.
  7. Grsf1 is important for axial elongation, mid/hindbrain development and axial mesoderm specification.
    Title: Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • B130010H02

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial RNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
G-rich sequence factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098476.2 → NP_001091946.1  G-rich sequence factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC121541, AC160533, AK077782, AK168385, CK391158
    Consensus CDS
    CCDS51540.1
    UniProtKB/TrEMBL
    E9Q179, Q8C298
    Related
    ENSMUSP00000108860.2, ENSMUST00000113234.8
    Conserved Domains (3) summary
    cd12505
    Location:131 → 204
    RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12730
    Location:31 → 109
    RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12733
    Location:283 → 357
    RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

  2. NM_178700.5 → NP_848815.2  G-rich sequence factor 1 isoform 1

    See identical proteins and their annotated locations for NP_848815.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC121541, AK044889, AK045986, AK077782
    Consensus CDS
    CCDS19404.1
    UniProtKB/Swiss-Prot
    Q8BR05, Q8BRG7, Q8C5Q4
    Related
    ENSMUSP00000077972.6, ENSMUST00000078945.12
    Conserved Domains (4) summary
    COG0724
    Location:155 → 325
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12505
    Location:248 → 321
    RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12730
    Location:148 → 226
    RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12733
    Location:400 → 474
    RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    88807092..88824030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5Q4.2 GenPept UniProtKB/Swiss-Prot:Q8C5Q4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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