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N4BP3 NEDD4 binding protein 3 [ Homo sapiens (human) ]

Gene ID: 23138, updated on 5-Mar-2024

Summary

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Official Symbol
N4BP3provided by HGNC
Official Full Name
NEDD4 binding protein 3provided by HGNC
Primary source
HGNC:HGNC:29852
See related
Ensembl:ENSG00000145911 MIM:619140; AllianceGenome:HGNC:29852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZTS4
Summary
Predicted to be involved in nervous system development. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 5.5), esophagus (RPKM 3.2) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
5q35.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178113532..178127034)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178663763..178677271)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177540533..177553082)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23733 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4886 Neighboring gene uncharacterized LOC105377754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16711 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:177541661-177542174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177547789-177548591 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177550999-177551800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177553540-177554200 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177554863-177555523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177556537-177557188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:177557189-177557840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177559119-177559648 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene Sharpr-MPRA regulatory region 11782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177577953-177578454 Neighboring gene NHP2 ribonucleoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:177590971-177591472 Neighboring gene NAD(P)HX epimerase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation. Luo M, et al. Cancer Lett, 2022 Dec 1. PMID 36162713
  2. N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B. Han H, et al. Cancer Sci, 2022 Oct. PMID 35848906, Free PMC Article
  3. The correlation analysis of miRNAs and target genes in metastasis of cervical squamous cell carcinoma. Zhou J, et al. Epigenomics, 2018 Mar. PMID 29343084
  4. N4BP3 Regulates RIG-I-Like Receptor Antiviral Signaling Positively by Targeting Mitochondrial Antiviral Signaling Protein. Wang C, et al. Front Microbiol, 2021. PMID 34880843, Free PMC Article
  5. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Liu S, et al. Elife, 2013 Aug 14. PMID 23951545, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation.
    Title: N4BP3 promotes breast cancer metastasis via NEDD4-mediated E-cadherin ubiquitination and degradation.
  2. N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B.
    Title: N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding with KAT2B.
  3. N4BP3 was associated with the survival time of cervical squamous cell carcinoma patients. mir-451 and mir-486 were related to tumor differentiation stage.
    Title: The correlation analysis of miRNAs and target genes in metastasis of cervical squamous cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0341

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_positive_effect innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NEDD4-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015111.2 → NP_055926.1  NEDD4-binding protein 3

    See identical proteins and their annotated locations for NP_055926.1

    Status: VALIDATED

    Source sequence(s)
    AC136632
    Consensus CDS
    CCDS34307.1
    UniProtKB/Swiss-Prot
    B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3
    Related
    ENSP00000274605.4, ENST00000274605.6
    Conserved Domains (1) summary
    pfam06818
    Location:368 → 526
    Fez1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178113532..178127034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534473.2 → XP_011532775.1  NEDD4-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532775.1

    UniProtKB/Swiss-Prot
    B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3
    Conserved Domains (1) summary
    pfam06818
    Location:368 → 526
    Fez1

  2. XM_011534474.2 → XP_011532776.1  NEDD4-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532776.1

    UniProtKB/Swiss-Prot
    B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3
    Conserved Domains (1) summary
    pfam06818
    Location:368 → 526
    Fez1

  3. XM_047416998.1 → XP_047272954.1  NEDD4-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3

  4. XM_047416997.1 → XP_047272953.1  NEDD4-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    B4DIL3, D3DWP3, O15049, Q6ZSQ6, Q7Z6I3

RNA

  1. XR_941094.2 RNA Sequence

  2. XR_941093.2 RNA Sequence

  3. XR_007058594.1 RNA Sequence

  4. XR_007058596.1 RNA Sequence

  5. XR_007058597.1 RNA Sequence

  6. XR_007058595.1 RNA Sequence

  7. XR_007058598.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    178663763..178677271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352158.1 → XP_054208133.1  NEDD4-binding protein 3 isoform X1

  2. XM_054352159.1 → XP_054208134.1  NEDD4-binding protein 3 isoform X1

  3. XM_054352160.1 → XP_054208135.1  NEDD4-binding protein 3 isoform X1

RNA

  1. XR_008487106.1 RNA Sequence

  2. XR_008487103.1 RNA Sequence

  3. XR_008487104.1 RNA Sequence

  4. XR_008487107.1 RNA Sequence

  5. XR_008487108.1 RNA Sequence

  6. XR_008487105.1 RNA Sequence

  7. XR_008487109.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15049.3 GenPept UniProtKB/Swiss-Prot:O15049

Gene LinkOut

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