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ERC1 ELKS/RAB6-interacting/CAST family member 1 [ Homo sapiens (human) ]

Gene ID: 23085, updated on 7-Apr-2024

Summary

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Official Symbol
ERC1provided by HGNC
Official Full Name
ELKS/RAB6-interacting/CAST family member 1provided by HGNC
Primary source
HGNC:HGNC:17072
See related
Ensembl:ENSG00000082805 MIM:607127; AllianceGenome:HGNC:17072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELKS; Cast2; ERC-1; RAB6IP2
Summary
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in thyroid (RPKM 7.0), esophagus (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12p13.33
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (989959..1495933)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (985850..1490194)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1100389..1605099)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U4atac small nuclear 16, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5791 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:917646-918146 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:918147-918647 Neighboring gene WNK lysine deficient protein kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5792 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:1023012-1024211 Neighboring gene uncharacterized LOC124902855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058032-1058690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058691-1059349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067429-1067930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067931-1068430 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:1083331-1083878 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:1092618-1092819 Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1099220-1099782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1100344-1100905 Neighboring gene Sharpr-MPRA regulatory region 6010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115216-1115716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115717-1116217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1181067-1181567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5795 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:1224566-1225765 Neighboring gene uncharacterized LOC124902857 Neighboring gene 5-hydroxytryptamine receptor 1D pseudogene 1 Neighboring gene uncharacterized LOC124902854 Neighboring gene NANOG hESC enhancer GRCh37_chr12:1359724-1360323 Neighboring gene MPRA-validated peak1534 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1412737-1413279 Neighboring gene uncharacterized LOC107987182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1551257-1551756 Neighboring gene uncharacterized LOC124902856 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:1554896-1555397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5797 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:1597926-1599125 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:1608954-1610153 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:1611914-1612112 Neighboring gene uncharacterized LOC107984507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4113 Neighboring gene long intergenic non-protein coding RNA 942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data. Cong S, et al. Neurobiol Aging, 2020 Nov. PMID 32768867, Free PMC Article
  2. Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells. Ohara-Imaizumi M, et al. Mol Metab, 2019 Sep. PMID 31500835, Free PMC Article
  3. A 1.5Mb terminal deletion of 12p associated with autism spectrum disorder. Silva IM, et al. Gene, 2014 May 25. PMID 24613754
  4. Rab6 dependent post-Golgi trafficking of HSV1 envelope proteins to sites of virus envelopment. Johns HL, et al. Traffic, 2014 Feb. PMID 24152084, Free PMC Article
  5. Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. Huijbers MG, et al. Hum Immunol, 2013 Jul. PMID 23583364

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interfering with the ERC1-LL5beta interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility.
    Title: Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility.
  2. Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
    Title: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
  3. Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data.
    Title: Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data.
  4. The ELKS forms a potent insulin secretion complex with L-type voltage-dependent Ca(2+) channels on the vascular-facing plasma membrane of beta-cells, enabling polarized Ca(2+) influx and first-phase insulin secretion from islets.
    Title: Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells.
  5. Several studies had established that ELKS is a redundant scaffold at the active zone, and that disruption of this scaffold impairs fusion of synaptic vesicles. In non-neuronal cells, scaffolding and exocytotic functions of ELKS seem to be important for constitutive secretion of other cargo. [review]
    Title: ELKS active zone proteins as multitasking scaffolds for secretion.
  6. Knockdown of ERC1, RAB4B, COPA, and COPB2, caused profound loss of virus production.
    Title: Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen.
  7. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility.
    Title: Identification of a membrane-less compartment regulating invadosome function and motility.
  8. ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.
    Title: ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains.
  9. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge
    Title: Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.
  10. a new, but rare, antigen in Lambert-Eaton myasthenic syndrome
    Title: Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31750, KIAA1081, MGC12974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural constituent of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in I-kappaB phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of presynaptic active zone structure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of IkappaB kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoskeleton of presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ELKS/Rab6-interacting/CAST family member 1
Names
RAB6 interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301248.1 → NP_001288177.1  ELKS/Rab6-interacting/CAST family member 1 isoform zeta

    Status: REVIEWED

    Description
    Transcript Variant: This variant (zeta) contains an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant epsilon. The encoded isoform (zeta) has a distinct C-terminus and is shorter than isoform epsilon. The 5' UTR of this variant is incomplete due to lack of full-length transcript support and splice site ambiguity in the 5'-most exon.
    Source sequence(s)
    AC004671, AC004803, BC144287, BM984956
    Consensus CDS
    CCDS76504.1
    UniProtKB/TrEMBL
    G8JLD3
    Related
    ENSP00000347621.5, ENST00000355446.9
    Conserved Domains (3) summary
    pfam10174
    Location:155 → 982
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam10211
    Location:767 → 832
    Ax_dynein_light; Axonemal dynein light chain
    cl21478
    Location:918 → 989
    ATP-synt_B; ATP synthase B/B' CF(0)

  2. NM_178039.4 → NP_829883.1  ELKS/Rab6-interacting/CAST family member 1 isoform delta

    See identical proteins and their annotated locations for NP_829883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (delta) lacks an alternate in-frame exon in the central coding region, compared to variant epsilon, resulting in a shorter isoform (delta), compared to isoform epsilon.
    Source sequence(s)
    AB053470, AC004671, AC004803, BM984956, DR000847
    Consensus CDS
    CCDS53732.1
    UniProtKB/Swiss-Prot
    Q8IUD2
    Related
    ENSP00000438546.1, ENST00000543086.7
    Conserved Domains (4) summary
    pfam09457
    Location:1040 → 1080
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 954
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam10211
    Location:739 → 804
    Ax_dynein_light; Axonemal dynein light chain
    cl21478
    Location:890 → 961
    ATP-synt_B; ATP synthase B/B' CF(0)

  3. NM_178040.4 → NP_829884.1  ELKS/Rab6-interacting/CAST family member 1 isoform epsilon

    See identical proteins and their annotated locations for NP_829884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (epsilon) encodes the longest isoform (epsilon).
    Source sequence(s)
    AB053471, AC004671, AC004672, AC004803, BM984956, DR000847
    Consensus CDS
    CCDS8508.1
    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
    Related
    ENSP00000354158.3, ENST00000360905.9
    Conserved Domains (4) summary
    pfam09457
    Location:1068 → 1108
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 982
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam10211
    Location:767 → 832
    Ax_dynein_light; Axonemal dynein light chain
    cl21478
    Location:918 → 989
    ATP-synt_B; ATP synthase B/B' CF(0)

RNA

  1. NR_027946.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) uses an alternate splice site in the 5' terminal exon, lacks two internal exons, and contains two additional exons, compared to variant epsilon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant epsilon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB015617, AC004671, AC004803, BM984956, DR000847

  2. NR_027948.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) uses an alternate splice site in the 5' terminal exon, lacks one internal exon, and contains two additional exons, compared to variant epsilon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant epsilon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB053468, AC004671, AC004803, BM984956, DR000847

  3. NR_027949.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma) lacks five internal exons and contains two additional exons, compared to variant epsilon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant epsilon, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB053469, AC004671, AC004803, BM984956, DR000847

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    989959..1495933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428566.1 → XP_047284522.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

  2. XM_047428562.1 → XP_047284518.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  3. XM_017019055.3 → XP_016874544.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  4. XM_047428563.1 → XP_047284519.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

  5. XM_047428558.1 → XP_047284514.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  6. XM_047428570.1 → XP_047284526.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  7. XM_047428576.1 → XP_047284532.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

  8. XM_017019054.2 → XP_016874543.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  9. XM_047428557.1 → XP_047284513.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  10. XM_047428561.1 → XP_047284517.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  11. XM_047428565.1 → XP_047284521.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

  12. XM_047428568.1 → XP_047284524.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  13. XM_047428572.1 → XP_047284528.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

  14. XM_047428574.1 → XP_047284530.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

  15. XM_047428579.1 → XP_047284535.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

  16. XM_017019052.2 → XP_016874541.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  17. XM_017019061.2 → XP_016874550.1  ELKS/Rab6-interacting/CAST family member 1 isoform X5

    Conserved Domains (3) summary
    pfam09457
    Location:1075 → 1115
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 989
    Cast; RIM-binding protein of the cytomatrix active zone
    cl21478
    Location:925 → 996
    ATP-synt_B; ATP synthase B/B' CF(0)

  18. XM_017019069.2 → XP_016874558.1  ELKS/Rab6-interacting/CAST family member 1 isoform X13

  19. XM_017019059.2 → XP_016874548.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

  20. XM_017019063.2 → XP_016874552.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

    Conserved Domains (4) summary
    pfam09457
    Location:1071 → 1111
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 985
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam10211
    Location:770 → 835
    Ax_dynein_light; Axonemal dynein light chain
    cl21478
    Location:921 → 992
    ATP-synt_B; ATP synthase B/B' CF(0)

  21. XM_017019057.2 → XP_016874546.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  22. XM_017019062.2 → XP_016874551.1  ELKS/Rab6-interacting/CAST family member 1 isoform X6

    UniProtKB/TrEMBL
    X6RLX0
    Related
    ENSP00000442739.2, ENST00000546231.6
    Conserved Domains (3) summary
    pfam09457
    Location:1072 → 1112
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 986
    Cast; RIM-binding protein of the cytomatrix active zone
    cl21478
    Location:922 → 993
    ATP-synt_B; ATP synthase B/B' CF(0)

  23. XM_017019060.2 → XP_016874549.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:261 → 986
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  24. XM_017019064.2 → XP_016874553.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
    Related
    ENSP00000380386.4, ENST00000397203.7
    Conserved Domains (4) summary
    pfam09457
    Location:1068 → 1108
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 982
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam10211
    Location:767 → 832
    Ax_dynein_light; Axonemal dynein light chain
    cl21478
    Location:918 → 989
    ATP-synt_B; ATP synthase B/B' CF(0)

  25. XM_017019070.2 → XP_016874559.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

  26. XM_017019065.2 → XP_016874554.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  27. XM_017019066.2 → XP_016874555.1  ELKS/Rab6-interacting/CAST family member 1 isoform X11

    Related
    ENSP00000410064.2, ENST00000440394.7

  28. XM_047428571.1 → XP_047284527.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

  29. XM_017019067.2 → XP_016874556.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

    UniProtKB/Swiss-Prot
    Q8IUD2
    Conserved Domains (4) summary
    pfam09457
    Location:1040 → 1080
    RBD-FIP; FIP domain
    pfam10174
    Location:155 → 954
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam10211
    Location:739 → 804
    Ax_dynein_light; Axonemal dynein light chain
    cl21478
    Location:890 → 961
    ATP-synt_B; ATP synthase B/B' CF(0)

  30. XM_047428578.1 → XP_047284534.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

  31. XM_017019072.2 → XP_016874561.1  ELKS/Rab6-interacting/CAST family member 1 isoform X16

  32. XM_047428580.1 → XP_047284536.1  ELKS/Rab6-interacting/CAST family member 1 isoform X17

  33. XM_047428583.1 → XP_047284539.1  ELKS/Rab6-interacting/CAST family member 1 isoform X20

  34. XM_047428581.1 → XP_047284537.1  ELKS/Rab6-interacting/CAST family member 1 isoform X18

  35. XM_047428584.1 → XP_047284540.1  ELKS/Rab6-interacting/CAST family member 1 isoform X21

    UniProtKB/TrEMBL
    X6RM00
    Related
    ENSP00000445336.2, ENST00000542302.6

  36. XM_047428582.1 → XP_047284538.1  ELKS/Rab6-interacting/CAST family member 1 isoform X19

  37. XM_017019056.2 → XP_016874545.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  38. XM_047428559.1 → XP_047284515.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

  39. XM_047428564.1 → XP_047284520.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

  40. XM_047428556.1 → XP_047284512.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  41. XM_047428560.1 → XP_047284516.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  42. XM_047428567.1 → XP_047284523.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1
    Related
    ENSP00000468263.1, ENST00000589028.6

  43. XM_047428577.1 → XP_047284533.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

  44. XM_047428569.1 → XP_047284525.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  45. XM_047428573.1 → XP_047284529.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

  46. XM_047428575.1 → XP_047284531.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

  47. XM_017019074.2 → XP_016874563.1  ELKS/Rab6-interacting/CAST family member 1 isoform X22

RNA

  1. XR_001748631.3 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171809.1 Reference GRCh38.p14 PATCHES

    Range
    38589..100408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    985850..1490194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371509.1 → XP_054227484.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

  2. XM_054371501.1 → XP_054227476.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  3. XM_054371492.1 → XP_054227467.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  4. XM_054371507.1 → XP_054227482.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

  5. XM_054371496.1 → XP_054227471.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  6. XM_054371514.1 → XP_054227489.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  7. XM_054371520.1 → XP_054227495.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

  8. XM_054371491.1 → XP_054227466.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  9. XM_054371502.1 → XP_054227477.1  ELKS/Rab6-interacting/CAST family member 1 isoform X5

  10. XM_054371521.1 → XP_054227496.1  ELKS/Rab6-interacting/CAST family member 1 isoform X13

  11. XM_054371504.1 → XP_054227479.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

  12. XM_054371495.1 → XP_054227470.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  13. XM_054371503.1 → XP_054227478.1  ELKS/Rab6-interacting/CAST family member 1 isoform X6

    UniProtKB/TrEMBL
    X6RLX0

  14. XM_054371500.1 → XP_054227475.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  15. XM_054371508.1 → XP_054227483.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

  16. XM_054371511.1 → XP_054227486.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  17. XM_054371516.1 → XP_054227491.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

  18. XM_054371518.1 → XP_054227493.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

  19. XM_054371527.1 → XP_054227502.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

  20. XM_054371528.1 → XP_054227503.1  ELKS/Rab6-interacting/CAST family member 1 isoform X16

  21. XM_054371529.1 → XP_054227504.1  ELKS/Rab6-interacting/CAST family member 1 isoform X17

  22. XM_054371533.1 → XP_054227508.1  ELKS/Rab6-interacting/CAST family member 1 isoform X20

  23. XM_054371530.1 → XP_054227505.1  ELKS/Rab6-interacting/CAST family member 1 isoform X18

  24. XM_054371534.1 → XP_054227509.1  ELKS/Rab6-interacting/CAST family member 1 isoform X21

    UniProtKB/TrEMBL
    X6RM00

  25. XM_054371532.1 → XP_054227507.1  ELKS/Rab6-interacting/CAST family member 1 isoform X24

  26. XM_054371535.1 → XP_054227510.1  ELKS/Rab6-interacting/CAST family member 1 isoform X25

  27. XM_054371489.1 → XP_054227464.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  28. XM_054371505.1 → XP_054227480.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

  29. XM_054371493.1 → XP_054227468.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  30. XM_054371499.1 → XP_054227474.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  31. XM_054371510.1 → XP_054227485.1  ELKS/Rab6-interacting/CAST family member 1 isoform X8

    UniProtKB/Swiss-Prot
    A2RU77, A7E295, D3DUP7, D3DUP8, Q6NVK2, Q8IUD2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1

  32. XM_054371523.1 → XP_054227498.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

  33. XM_054371512.1 → XP_054227487.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  34. XM_054371515.1 → XP_054227490.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

  35. XM_054371519.1 → XP_054227494.1  ELKS/Rab6-interacting/CAST family member 1 isoform X12

  36. XM_054371525.1 → XP_054227500.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

  37. XM_054371490.1 → XP_054227465.1  ELKS/Rab6-interacting/CAST family member 1 isoform X1

  38. XM_054371497.1 → XP_054227472.1  ELKS/Rab6-interacting/CAST family member 1 isoform X3

  39. XM_054371506.1 → XP_054227481.1  ELKS/Rab6-interacting/CAST family member 1 isoform X7

  40. XM_054371522.1 → XP_054227497.1  ELKS/Rab6-interacting/CAST family member 1 isoform X23

  41. XM_054371494.1 → XP_054227469.1  ELKS/Rab6-interacting/CAST family member 1 isoform X2

  42. XM_054371498.1 → XP_054227473.1  ELKS/Rab6-interacting/CAST family member 1 isoform X4

  43. XM_054371524.1 → XP_054227499.1  ELKS/Rab6-interacting/CAST family member 1 isoform X14

  44. XM_054371513.1 → XP_054227488.1  ELKS/Rab6-interacting/CAST family member 1 isoform X9

  45. XM_054371517.1 → XP_054227492.1  ELKS/Rab6-interacting/CAST family member 1 isoform X10

  46. XM_054371526.1 → XP_054227501.1  ELKS/Rab6-interacting/CAST family member 1 isoform X15

  47. XM_054371531.1 → XP_054227506.1  ELKS/Rab6-interacting/CAST family member 1 isoform X19

  48. XM_054371536.1 → XP_054227511.1  ELKS/Rab6-interacting/CAST family member 1 isoform X22

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IUD2.1 GenPept UniProtKB/Swiss-Prot:Q8IUD2

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