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PPRC1 PPARG related coactivator 1 [ Homo sapiens (human) ]

Gene ID: 23082, updated on 7-Apr-2024

Summary

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Official Symbol
PPRC1provided by HGNC
Official Full Name
PPARG related coactivator 1provided by HGNC
Primary source
HGNC:HGNC:30025
See related
Ensembl:ENSG00000148840 MIM:617462; AllianceGenome:HGNC:30025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRC
Summary
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 7.9), appendix (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.32
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102119889..102150333)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103005469..103035313)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103892797..103910090)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 3 Neighboring gene uncharacterized LOC124902492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2735 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103698366-103699565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103795088-103795895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2737 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2738 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103867277-103867778 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103870016-103871215 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2741 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103876901-103877603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103877604-103878305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2745 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103880011-103880762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103880763-103881514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103881515-103882264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103887116-103887946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2750 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103897995-103899194 Neighboring gene LIM domain binding 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103911632-103912831 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2751 Neighboring gene ELOVL fatty acid elongase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma. Ruan X, et al. Medicina (Kaunas), 2023 Apr 17. PMID 37109742, Free PMC Article
  2. A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study. Zhang XJ, et al. J Gene Med, 2021 Jun. PMID 33818872
  3. Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. Gleyzer N, et al. J Biol Chem, 2013 Mar 22. PMID 23364789, Free PMC Article
  4. PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours. Raharijaona M, et al. PLoS One, 2009 Nov 23. PMID 19956726, Free PMC Article
  5. Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. Yamagata K, et al. Int J Mol Med, 2007 May. PMID 17390079

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma.
    Title: Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma.
  2. A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study.
    Title: A novel PPRC1 point mutation in a Chinese family with premature ovarian failure: A case study.
  3. PRC and c-MYC can act in concert through Akt-GSK-3 signaling to reprogram gene expression in response to mitochondrial stress.
    Title: Concerted Action of PGC-1-related Coactivator (PRC) and c-MYC in the Stress Response to Mitochondrial Dysfunction.
  4. PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB activity
    Title: PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity.
  5. A general role for PRC in the adaptive response to cellular dysfunction.
    Title: Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence.
  6. PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle
    Title: PGC-1-related coactivator modulates mitochondrial-nuclear crosstalk through endogenous nitric oxide in a cellular model of oncocytic thyroid tumours.
  7. support a role for PRC in the integration of pathways directing mitochondrial respiratory function and cell growth
    Title: Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria.
  8. Meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
  10. The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.
    Title: PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0595, MGC74642, RP11-302K17.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Names
PGC-1-related coactivator
peroxisome proliferator-activated receptor gamma, coactivator-related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047132.2 RefSeqGene

    Range
    18153..35446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288727.2 → NP_001275656.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AB011167, BU742486, HY023373
    Consensus CDS
    CCDS73186.1
    UniProtKB/TrEMBL
    B4DSS0, E7EVG6
    Related
    ENSP00000399743.2, ENST00000413464.6
    Conserved Domains (1) summary
    cd12624
    Location:1277 → 1367
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  2. NM_001288728.2 → NP_001275657.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB011167, AF325193, BC063806, BU742486, HY023373
    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (1) summary
    cd12624
    Location:1419 → 1509
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  3. NM_015062.5 → NP_055877.3  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055877.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB011167, BU742486, HY023373
    Consensus CDS
    CCDS7529.1
    UniProtKB/Swiss-Prot
    Q5VV66, Q5VV67, Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5, Q9Y4E0
    UniProtKB/TrEMBL
    B4DSS0
    Related
    ENSP00000278070.2, ENST00000278070.7
    Conserved Domains (1) summary
    cd12624
    Location:1541 → 1631
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102119889..102150333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424879.1 → XP_047280835.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  2. XM_024447914.2 → XP_024303682.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (2) summary
    cd12624
    Location:1462 → 1552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:531 → 1123
    Atrophin-1; Atrophin-1 family

  3. XM_047424878.1 → XP_047280834.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  4. XM_024447917.2 → XP_024303685.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (2) summary
    cd12624
    Location:1462 → 1552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:531 → 1123
    Atrophin-1; Atrophin-1 family

  5. XM_024447915.2 → XP_024303683.2  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

  6. XM_047424885.1 → XP_047280841.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

  7. XM_017015982.2 → XP_016871471.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

    UniProtKB/TrEMBL
    B4DSS0

  8. XM_017015984.2 → XP_016871473.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

    UniProtKB/TrEMBL
    B4DSS0

  9. XM_011539549.3 → XP_011537851.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (1) summary
    cd12624
    Location:1498 → 1588
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  10. XM_047424876.1 → XP_047280832.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

  11. XM_017015983.2 → XP_016871472.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

    UniProtKB/TrEMBL
    B4DSS0

  12. XM_047424877.1 → XP_047280833.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

  13. XM_011539551.3 → XP_011537853.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (1) summary
    cd12624
    Location:1458 → 1548
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  14. XM_047424880.1 → XP_047280836.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

  15. XM_047424886.1 → XP_047280842.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X15

  16. XM_047424881.1 → XP_047280837.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

  17. XM_047424882.1 → XP_047280838.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

  18. XM_047424887.1 → XP_047280843.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X16

  19. XM_006717731.4 → XP_006717794.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X17

    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (1) summary
    PHA03247
    Location:610 → 1136
    PHA03247; large tegument protein UL36; Provisional

  20. XM_047424884.1 → XP_047280840.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

  21. XM_024447916.2 → XP_024303684.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    UniProtKB/TrEMBL
    B4DSS0
    Conserved Domains (2) summary
    cd12624
    Location:1462 → 1552
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    cl26464
    Location:531 → 1123
    Atrophin-1; Atrophin-1 family

  22. XM_047424883.1 → XP_047280839.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103005469..103035313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365301.1 → XP_054221276.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  2. XM_054365303.1 → XP_054221278.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  3. XM_054365302.1 → XP_054221277.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  4. XM_054365304.1 → XP_054221279.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  5. XM_054365295.1 → XP_054221270.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

  6. XM_054365312.1 → XP_054221287.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

  7. XM_054365296.1 → XP_054221271.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

  8. XM_054365313.1 → XP_054221288.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

  9. XM_054365297.1 → XP_054221272.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

  10. XM_054365298.1 → XP_054221273.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

  11. XM_054365299.1 → XP_054221274.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

  12. XM_054365300.1 → XP_054221275.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

  13. XM_054365305.1 → XP_054221280.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

  14. XM_054365306.1 → XP_054221281.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

  15. XM_054365314.1 → XP_054221289.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X15

  16. XM_054365307.1 → XP_054221282.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

  17. XM_054365308.1 → XP_054221283.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

  18. XM_054365315.1 → XP_054221290.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X16

  19. XM_054365316.1 → XP_054221291.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X17

  20. XM_054365310.1 → XP_054221285.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

  21. XM_054365311.1 → XP_054221286.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  22. XM_054365309.1 → XP_054221284.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VV67.1 GenPept UniProtKB/Swiss-Prot:Q5VV67

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