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Ecpas Ecm29 proteasome adaptor and scaffold [ Mus musculus (house mouse) ]

Gene ID: 230249, updated on 2-Nov-2024

Summary

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Official Symbol
Ecpasprovided by MGI
Official Full Name
Ecm29 proteasome adaptor and scaffoldprovided by MGI
Primary source
MGI:MGI:2140220
See related
Ensembl:ENSMUSG00000050812 AllianceGenome:MGI:2140220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0368
Summary
Predicted to enable molecular adaptor activity and proteasome binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. Predicted to be part of proteasome complex. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; cerebral cortex; cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cortical plate. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.2), bladder adult (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ecpas in Genome Data Viewer
Location:
4 B3; 4 32.35 cM
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58797234..58917748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58797234..58917748, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12579 Neighboring gene STARR-seq mESC enhancer starr_10362 Neighboring gene STARR-seq mESC enhancer starr_10364 Neighboring gene STARR-seq mESC enhancer starr_10365 Neighboring gene olfactory receptor family 2 subfamily K member 2 Neighboring gene STARR-positive B cell enhancer ABC_E6181 Neighboring gene zinc finger with KRAB and SCAN domains 16 Neighboring gene prostaglandin reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for Murine Spermatogenesis. Sato B, et al. Biomolecules, 2023 Mar 24. PMID 37189334, Free PMC Article
  2. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. Gorbea C, et al. J Biol Chem, 2004 Dec 24. PMID 15496406
  3. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Lee M, et al. J Cell Biol, 2020 Feb 3. PMID 31910261, Free PMC Article
  4. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.
    Title: Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0368

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proteasome adapter and scaffold protein ECM29
Names
ecm29
proteasome-associated protein ECM29 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355696.1 → NP_001342625.1  proteasome adapter and scaffold protein ECM29 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK030369, AK043020, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
    UniProtKB/TrEMBL
    A2ALV7
    Conserved Domains (2) summary
    sd00044
    Location:1085 → 1108
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:16 → 523
    Ecm29; Proteasome stabilizer

  2. NM_001355697.1 → NP_001342626.1  proteasome adapter and scaffold protein ECM29 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK030369, AK043020, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
    UniProtKB/Swiss-Prot
    A2ALW0, Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6
    UniProtKB/TrEMBL
    A2ALV7
    Related
    ENSMUSP00000117585.2, ENSMUST00000149301.8
    Conserved Domains (2) summary
    sd00044
    Location:1079 → 1102
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:10 → 517
    Ecm29; Proteasome stabilizer

  3. NM_172381.3 → NP_759013.2  proteasome adapter and scaffold protein ECM29 isoform 2

    See identical proteins and their annotated locations for NP_759013.2

    Status: VALIDATED

    Source sequence(s)
    AK030369, AK041579, AK054077, AL806535, AW123771, BC058684, BE648557, BG079097
    Consensus CDS
    CCDS18214.1
    UniProtKB/TrEMBL
    A2ALV7
    Related
    ENSMUSP00000099953.4, ENSMUST00000102889.10
    Conserved Domains (2) summary
    pfam13001
    Location:10 → 517
    Ecm29; Proteasome stabilizer
    sd00044
    Location:1079 → 1102
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    58797234..58917748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537848.4 → XP_006537911.1  proteasome adapter and scaffold protein ECM29 isoform X1

    See identical proteins and their annotated locations for XP_006537911.1

    UniProtKB/Swiss-Prot
    A2ALW0, Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6
    UniProtKB/TrEMBL
    A2ALV7
    Conserved Domains (2) summary
    sd00044
    Location:1079 → 1102
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:10 → 517
    Ecm29; Proteasome stabilizer

  2. XM_006537850.5 → XP_006537913.1  proteasome adapter and scaffold protein ECM29 isoform X2

    UniProtKB/TrEMBL
    A2ALV7
    Conserved Domains (2) summary
    sd00044
    Location:1027 → 1050
    HEAT; HEAT repeat [structural motif]
    pfam13001
    Location:1 → 465
    Ecm29; Proteasome stabilizer
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDI5.4 GenPept UniProtKB/Swiss-Prot:Q6PDI5

Gene LinkOut

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