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Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 [ Mus musculus (house mouse) ]

Gene ID: 230145, updated on 2-Nov-2024

Summary

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Official Symbol
Galnt12provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 12provided by MGI
Primary source
MGI:MGI:2444664
See related
Ensembl:ENSMUSG00000039774 AllianceGenome:MGI:2444664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130206E10; galNAc-T12; pp-GaNTase; A630062B03Rik; pp-GaNTase 12; mpp-GalNAc-T12
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nervous system; and submandibular gland primordium. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 53.1), stomach adult (RPKM 17.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Galnt12 in Genome Data Viewer
Location:
4 B1; 4 25.96 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (47091894..47123058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (47091894..47123058)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:47033511-47033812 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 6 Neighboring gene uncharacterized LOC118568655 Neighboring gene STARR-seq mESC enhancer starr_10140 Neighboring gene predicted gene, 52731 Neighboring gene predicted gene 12426 Neighboring gene collagen, type XV, alpha 1 Neighboring gene predicted gene, 32317

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Anks6 leads to YAP deficiency and liver abnormalities. Airik M, et al. Hum Mol Genet, 2020 Nov 4. PMID 32886109, Free PMC Article
  2. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
  3. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 12
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12
polypeptide GalNAc transferase 12
protein-UDP acetylgalactosaminyltransferase 12
NP_766281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172693.4 → NP_766281.1  polypeptide N-acetylgalactosaminyltransferase 12

    See identical proteins and their annotated locations for NP_766281.1

    Status: VALIDATED

    Source sequence(s)
    AK033638, AK043977, CK627557
    Consensus CDS
    CCDS18158.1
    UniProtKB/Swiss-Prot
    Q8BGT9
    UniProtKB/TrEMBL
    Q60GT3
    Related
    ENSMUSP00000045721.6, ENSMUST00000045041.12
    Conserved Domains (4) summary
    cd02510
    Location:134 → 428
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:129 → 424
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:442 → 571
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:440 → 569
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RNA

  1. NR_156438.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK043977, CK627557
    Related
    ENSMUST00000107744.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    47091894..47123058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954907.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGT9.1 GenPept UniProtKB/Swiss-Prot:Q8BGT9

Gene LinkOut

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