MAPRE1 microtubule associated protein RP/EB family member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPRE1provided by HGNC
Official Full Name: microtubule associated protein RP/EB family member 1provided by HGNC
Primary source: HGNC:HGNC:6890
See related: Ensembl:ENSG00000101367 MIM:603108; AllianceGenome:HGNC:6890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EB1
Summary: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 71.1), thyroid (RPKM 48.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (32819777..32850405)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (34546449..34577086)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (31407760..31438211)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

End-binding protein 1 regulates the metabolic fate of CD4[+] T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network.
Title: End-binding protein 1 regulates the metabolic fate of CD4(+) T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network.
Kinetochore-microtubule attachment in human cells is regulated by the interaction of a conserved motif of Ska1 with EB1.
Title: Kinetochore-microtubule attachment in human cells is regulated by the interaction of a conserved motif of Ska1 with EB1.
Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant.
Title: Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant.
Phase separation of EB1 guides microtubule plus-end dynamics.
Title: Phase separation of EB1 guides microtubule plus-end dynamics.
CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration.
Title: CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration.
Redox-dependent regulation of end-binding protein 1 activity by glutathionylation.
Title: Redox-dependent regulation of end-binding protein 1 activity by glutathionylation.
EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK.
Title: EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK.
EB1 Directly Regulates APC-Mediated Actin Nucleation.
Title: EB1 Directly Regulates APC-Mediated Actin Nucleation.
MAPRE1 promotes cell cycle progression of hepatocellular carcinoma cells by interacting with CDK2.
Title: MAPRE1 promotes cell cycle progression of hepatocellular carcinoma cells by interacting with CDK2.
Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis.
Title: Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr relocalizes MAPRE1 (EB1) from the plus ends of microtubules in infected primary human macrophages	PubMed
	vpr	EB1-mediated stable microtubules enhance HIV-1 infection and is required for efficient translocation of HIV-1 GFP-Vpr labelled viral particles across the cytoplasm	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S2001 (e-PCR)
- UniSTS:56338

RH67821 (e-PCR)
- UniSTS:37925

HSC03G092 (e-PCR)
- UniSTS:80959

NoName (e-PCR)
- UniSTS:489831

RH18019 (e-PCR)
- UniSTS:41093

D5S1940 (e-PCR)
- UniSTS:154259

SHGC-145265 (e-PCR)
- UniSTS:183506

PMC321570P4 (e-PCR)
- UniSTS:273118

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IDA Inferred from Direct Assay more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to astral microtubule	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to centrosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to microtubule	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in cortical microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle astral microtubule end	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: microtubule-associated protein RP/EB family member 1

Names: APC-binding protein EB1; adenomatous polyposis coli-binding protein EB1; end-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012325.3 → NP_036457.1 microtubule-associated protein RP/EB family member 1

See identical proteins and their annotated locations for NP_036457.1

Status: REVIEWED

Source sequence(s)

BC106068, BJ992159, BM983860

Consensus CDS

CCDS13208.1

UniProtKB/Swiss-Prot

B2R6I7, E1P5M8, Q15691, Q3KQS8

UniProtKB/TrEMBL

B4DM33

Related

ENSP00000364721.5, ENST00000375571.6

Conserved Domains (1) summary

COG5217
Location:16 → 257

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

32819777..32850405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528696.3 → XP_011526998.1 microtubule-associated protein RP/EB family member 1 isoform X1

See identical proteins and their annotated locations for XP_011526998.1

UniProtKB/Swiss-Prot

B2R6I7, E1P5M8, Q15691, Q3KQS8

UniProtKB/TrEMBL

B4DM33

Conserved Domains (1) summary

COG5217
Location:16 → 257

BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]