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Arfgap1 ADP-ribosylation factor GTPase activating protein 1 [ Mus musculus (house mouse) ]

Gene ID: 228998, updated on 18-Sep-2024

Summary

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Official Symbol
Arfgap1provided by MGI
Official Full Name
ADP-ribosylation factor GTPase activating protein 1provided by MGI
Primary source
MGI:MGI:2183559
See related
Ensembl:ENSMUSG00000027575 AllianceGenome:MGI:2183559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arf1gap
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within regulation of endocytosis. Located in postsynaptic density. Is expressed in axial skeleton; craniocervical region bone; inner ear; and lower jaw mesenchyme. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 31.8), ovary adult (RPKM 22.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arfgap1 in Genome Data Viewer
Location:
2 H4; 2 103.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180608290..180624319)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180967225..180982526)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat-containing 7 Neighboring gene Na+/K+ transporting ATPase interacting 4 Neighboring gene STARR-seq mESC enhancer starr_06745 Neighboring gene collagen, type XX, alpha 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High abundance of ArfGAP1 found in the mossy fibers in hilus of the dentate gyrus region of the mouse brain. Chornyy S, et al. PLoS One, 2017. PMID 29240824, Free PMC Article
  2. Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins. Jacques KM, et al. J Biol Chem, 2002 Dec 6. PMID 12376537
  3. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Yang Y, et al. Hum Mol Genet, 2003 May 1. PMID 12700166
  4. GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. Stafa K, et al. PLoS Genet, 2012. PMID 22363216, Free PMC Article
  5. ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. Xiong Y, et al. J Neurosci, 2012 Mar 14. PMID 22423108, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data suggest that ArfGAP1 can be used as a specific marker of the dentate mossy fibers and as for visualization of cortical layers in immunohistochemical studies
    Title: High abundance of ArfGAP1 found in the mossy fibers in hilus of the dentate gyrus region of the mouse brain.
  2. termination of Arf1 signals mediated through GGA require that Arf1.GTP dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP
    Title: Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor GTPase-activating protein 1
Names
ADP-ribosylation factor 1 GTPase activating protein
ARF GAP 1
ARF1 GAP
ARF1-directed GTPase-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177706.2 → NP_001171177.1  ADP-ribosylation factor GTPase-activating protein 1 isoform b

    See identical proteins and their annotated locations for NP_001171177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    BX649560
    Consensus CDS
    CCDS50843.1
    UniProtKB/TrEMBL
    Q6PB94
    Related
    ENSMUSP00000104487.2, ENSMUST00000108859.8
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  2. NM_001177707.1 → NP_001171178.1  ADP-ribosylation factor GTPase-activating protein 1 isoform c

    See identical proteins and their annotated locations for NP_001171178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AK134402, AK145879, BY630306, CJ149044
    Consensus CDS
    CCDS50842.1
    UniProtKB/TrEMBL
    Q3TGS9, Q6PB94
    Related
    ENSMUSP00000104489.2, ENSMUST00000108861.8
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  3. NM_001177708.1 → NP_001171179.1  ADP-ribosylation factor GTPase-activating protein 1 isoform c

    See identical proteins and their annotated locations for NP_001171179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AK145879, AK168602, BY630306, CJ149044
    Consensus CDS
    CCDS50842.1
    UniProtKB/TrEMBL
    Q3TGS9, Q6PB94
    Related
    ENSMUSP00000104490.2, ENSMUST00000108862.8
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  4. NM_001177709.1 → NP_001171180.1  ADP-ribosylation factor GTPase-activating protein 1 isoform b

    See identical proteins and their annotated locations for NP_001171180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK145879, BC059817, BY630306, CJ150232
    Consensus CDS
    CCDS50843.1
    UniProtKB/TrEMBL
    Q6PB94
    Related
    ENSMUSP00000104488.2, ENSMUST00000108860.8
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  5. NM_001177710.1 → NP_001171181.1  ADP-ribosylation factor GTPase-activating protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (d) lacks an internal segment near the N-terminus, compared to isoform a.
    Source sequence(s)
    BX649560
    UniProtKB/TrEMBL
    Q05DE0
    Related
    ENSMUST00000136590.8
    Conserved Domains (2) summary
    pfam13257
    Location:262 → 313
    DUF4048; Domain of unknown function (DUF4048)
    cl02464
    Location:2 → 71
    ArfGap; Putative GTPase activating protein for Arf

  6. NM_001363035.1 → NP_001349964.1  ADP-ribosylation factor GTPase-activating protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform e.
    Source sequence(s)
    BX649560
    Consensus CDS
    CCDS89604.1
    UniProtKB/TrEMBL
    Q6PB94, V9GWV1
    Related
    ENSMUSP00000138843.2, ENSMUST00000184394.2
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  7. NM_001363036.1 → NP_001349965.1  ADP-ribosylation factor GTPase-activating protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform e.
    Source sequence(s)
    BX649560
    Consensus CDS
    CCDS89604.1
    UniProtKB/TrEMBL
    Q6PB94, V9GWV1
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  8. NM_001363037.1 → NP_001349966.1  ADP-ribosylation factor GTPase-activating protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    BX649560
    UniProtKB/TrEMBL
    Q6PB94
    Conserved Domains (1) summary
    cl27571
    Location:2 → 71
    ArfGap; Putative GTPase activating protein for Arf

  9. NM_001374670.1 → NP_001361599.1  ADP-ribosylation factor GTPase-activating protein 1 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) encodes the longest isoform (g).
    Source sequence(s)
    BX649560
    Consensus CDS
    CCDS89603.1
    UniProtKB/TrEMBL
    Q6PB94, V9GXM1
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  10. NM_145760.3 → NP_665703.2  ADP-ribosylation factor GTPase-activating protein 1 isoform a

    See identical proteins and their annotated locations for NP_665703.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK145879, BY630306, CJ149044
    Consensus CDS
    CCDS17190.1
    UniProtKB/Swiss-Prot
    A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
    UniProtKB/TrEMBL
    Q6PB94
    Related
    ENSMUSP00000029092.7, ENSMUST00000029092.13
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180608290..180624319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161736.1 → XP_036017629.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
    UniProtKB/TrEMBL
    Q6PB94
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  2. XM_030250858.2 → XP_030106718.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6PB94
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  3. XM_030250845.2 → XP_030106705.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
    UniProtKB/TrEMBL
    Q6PB94
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  4. XM_006500594.3 → XP_006500657.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006500657.1

    UniProtKB/TrEMBL
    Q6PB94, V9GXM1
    Related
    ENSMUSP00000139222.2, ENSMUST00000185115.8
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  5. XM_030250844.2 → XP_030106704.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X2

    UniProtKB/Swiss-Prot
    A8WIR9, A8WIS1, Q3TI52, Q8BMM6, Q8BMQ7, Q9EPJ9
    UniProtKB/TrEMBL
    Q6PB94
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  6. XM_030250846.1 → XP_030106706.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X3

    UniProtKB/TrEMBL
    Q6PB94, V9GWV1
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  7. XM_030250848.1 → XP_030106708.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3TGS9, Q6PB94
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  8. XM_030250850.2 → XP_030106710.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6PB94
    Conserved Domains (1) summary
    cd08830
    Location:6 → 121
    ArfGap_ArfGap1; Arf1 GTPase-activating protein 1

  9. XM_011239936.3 → XP_011238238.1  ADP-ribosylation factor GTPase-activating protein 1 isoform X6

RNA

  1. XR_001782401.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPJ9.2 GenPept UniProtKB/Swiss-Prot:Q9EPJ9

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