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Zfp217 zinc finger protein 217 [ Mus musculus (house mouse) ]

Gene ID: 228913, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp217provided by MGI
Official Full Name
zinc finger protein 217provided by MGI
Primary source
MGI:MGI:2685408
See related
Ensembl:ENSMUSG00000052056 AllianceGenome:MGI:2685408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm562; ZABC1; Znf217; 4933431C08Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cellular senescence. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; paraxial mesenchyme; and tail. Orthologous to human ZNF217 (zinc finger protein 217). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 23.1), thymus adult (RPKM 7.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp217 in Genome Data Viewer
Location:
2 H3; 2 89.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (169950563..169993598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170108643..170151677, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger family member 2 Neighboring gene STARR-seq mESC enhancer starr_06500 Neighboring gene cDNA sequence AY702102 Neighboring gene STARR-seq mESC enhancer starr_06501 Neighboring gene STARR-seq mESC enhancer starr_06502 Neighboring gene STARR-seq mESC enhancer starr_06503 Neighboring gene RIKEN cDNA A630075F10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169978978-169979087 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:169980510-169980753 Neighboring gene STARR-positive B cell enhancer ABC_E9210 Neighboring gene STARR-positive B cell enhancer ABC_E10165 Neighboring gene STARR-positive B cell enhancer ABC_E2658 Neighboring gene STARR-seq mESC enhancer starr_06515 Neighboring gene predicted gene, 34403 Neighboring gene predicted gene, 17619

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice. Zeng Q, et al. Int J Mol Sci, 2021 May 20. PMID 34065474, Free PMC Article
  2. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Aguilo F, et al. Cell Stem Cell, 2015 Dec 3. PMID 26526723, Free PMC Article
  3. The Emerging Role of Zfp217 in Adipogenesis. Xiang H, et al. Int J Mol Sci, 2017 Jun 27. PMID 28653987, Free PMC Article
  4. Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Song T, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31037292, Free PMC Article
  5. Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation. Kwak S, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29846698, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice.
    Title: Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice.
  2. ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner.
    Title: ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner.
  3. Zfp217 couples gene transcription to m6A mRNA modification to facilitate adipogenesis.
    Title: Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
  4. Zfp217 and Zfp516 facilitate Ctbp2-mediated repression on active embryonic stem cell genes during differentiation.
    Title: Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.
  5. Three microRNAs (miR-503-5p, miR-135a-5p and miR-19a-3p) which target Zfp217 were found to suppress the process of adipogenesis. This is the first report showing that Zfp217 has the capacity to regulate adipogenesis.
    Title: The Emerging Role of Zfp217 in Adipogenesis.
  6. ZFP217 regulates N6-methyladenosine mRNA deposition in embryonic stem cells thus contributing to tumorigenesis by dysregulating gene expression programs.
    Title: ZNF217/ZFP217 Meets Chromatin and RNA.
  7. ZFP217 has a role in regulating pluripotency and reprogramming and is coordinated by m(6)A mRNA methylation
    Title: Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.
  8. results show that ZNF217 regulates ErbB3 expression
    Title: ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells.
  9. These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP.
    Title: Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular senescence ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 217

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033299.4 → NP_001028471.1  zinc finger protein 217

    See identical proteins and their annotated locations for NP_001028471.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL844576
    Consensus CDS
    CCDS17120.1
    UniProtKB/TrEMBL
    Q3U0X6
    Related
    ENSMUSP00000067334.7, ENSMUST00000063710.13
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. NM_001159683.1 → NP_001153155.1  zinc finger protein 217

    See identical proteins and their annotated locations for NP_001153155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK139547, AL844576, BC116330
    Consensus CDS
    CCDS17120.1
    UniProtKB/TrEMBL
    Q3U0X6
    Related
    ENSMUSP00000104783.2, ENSMUST00000109155.8
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. NM_001434160.1 → NP_001421089.1  zinc finger protein 217

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL844576

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    169950563..169993598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499428.4 → XP_006499491.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_006499491.1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_006499430.3 → XP_006499493.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_006499493.1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. XM_006499434.4 → XP_006499497.1  zinc finger protein 217 isoform X2

    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  4. XM_006499427.4 → XP_006499490.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_006499490.1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  5. XM_006499429.5 → XP_006499492.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_006499492.1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  6. XM_030250755.1 → XP_030106615.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  7. XM_036161709.1 → XP_036017602.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  8. XM_006499431.4 → XP_006499494.1  zinc finger protein 217 isoform X1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  9. XM_006499432.5 → XP_006499495.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_006499495.1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain

  10. XM_006499433.4 → XP_006499496.1  zinc finger protein 217 isoform X1

    See identical proteins and their annotated locations for XP_006499496.1

    UniProtKB/TrEMBL
    Q3U0X6
    Conserved Domains (5) summary
    sd00017
    Location:123 → 143
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 500
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:506 → 530
    zf-H2C2_5; C2H2-type zinc-finger domain
Nucleotide Protein Strain
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