Pigu phosphatidylinositol glycan anchor biosynthesis, class U [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Piguprovided by MGI
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Uprovided by MGI
Primary source: MGI:MGI:3039607
See related: Ensembl:ENSMUSG00000038383 AllianceGenome:MGI:3039607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc91l1; 5430426F17Rik
Summary: Predicted to contribute to GPI anchor binding activity. Predicted to be involved in GPI anchor biosynthetic process; attachment of GPI anchor to protein; and regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in plasma membrane. Predicted to be part of GPI-anchor transamidase complex. Is expressed in 1st branchial arch; forebrain; and limb. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 21.0), ovary adult (RPKM 19.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.18 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155120163..155199344, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155278243..155357424, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to GPI anchor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of GPI anchor to protein	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	ISO Inferred from Sequence Orthology more info
part_of GPI-anchor transamidase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol glycan anchor biosynthesis class U protein

Names: CDC91 cell division cycle 91-like 1; GPI transamidase component PIG-U; cell division cycle 91-like 1; cell division cycle protein 91-like 1; phosphatidylinositol-glycan biosynthesis, class U protein; protein CDC91-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004721.1 → NP_001004721.1 phosphatidylinositol glycan anchor biosynthesis class U protein

See identical proteins and their annotated locations for NP_001004721.1

Status: VALIDATED

Source sequence(s)

AW046539, AW538039, BB839941, BE646884, CK334159

Consensus CDS

CCDS16946.1

UniProtKB/Swiss-Prot

Q8K358, Q921E1

UniProtKB/TrEMBL

Q3TAA8

Related

ENSMUSP00000076816.7, ENSMUST00000077626.13

Conserved Domains (1) summary

pfam06728
Location:20 → 394

PIG-U; GPI transamidase subunit PIG-U

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

155120163..155199344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499333.1 → XP_006499396.1 phosphatidylinositol glycan anchor biosynthesis class U protein isoform X1

UniProtKB/Swiss-Prot

Q8K358, Q921E1

Conserved Domains (1) summary

pfam06728
Location:1 → 310

PIG-U; GPI transamidase subunit PIG-U