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TRAPPC8 trafficking protein particle complex subunit 8 [ Homo sapiens (human) ]

Gene ID: 22878, updated on 3-Nov-2024

Summary

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Official Symbol
TRAPPC8provided by HGNC
Official Full Name
trafficking protein particle complex subunit 8provided by HGNC
Primary source
HGNC:HGNC:29169
See related
Ensembl:ENSG00000153339 MIM:614136; AllianceGenome:HGNC:29169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSG1; TRS85; HsT2706; KIAA1012
Summary
Involved in Golgi organization and collagen biosynthetic process. Part of TRAPP complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 23.5), thyroid (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

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See TRAPPC8 in Genome Data Viewer
Location:
18q12.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (31829197..31943128, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (32019706..32133657, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29409160..29523091, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene golgi SNAP receptor complex member 2 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:29318221-29319420 Neighboring gene solute carrier family 25 member 52 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13207 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29383595-29384386 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29389007-29389784 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29389785-29390562 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29390563-29391340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:29399375-29399875 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29405731-29406276 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29406277-29406822 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29406823-29407368 Neighboring gene MPRA-validated peak3103 silencer Neighboring gene family with sequence similarity 76 member A pseudogene Neighboring gene MPRA-validated peak3104 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:29521986-29522764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13208 Neighboring gene RNA, U6 small nuclear 1050, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29526223-29526906 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:29526907-29527590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9387 Neighboring gene epsin 2 pseudogene Neighboring gene phosphogluconate dehydrogenase pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic. Lamb CA, et al. EMBO J, 2016 Feb 1. PMID 26711178, Free PMC Article
  2. The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability. Zong M, et al. PLoS One, 2011. PMID 21858081, Free PMC Article
  3. Identification and characterization of five new subunits of TRAPP. Sacher M, et al. Eur J Cell Biol, 2000 Feb. PMID 10727015
  4. Organization and assembly of the TRAPPII complex. Choi C, et al. Traffic, 2011 Jun. PMID 21453443
  5. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Zhang Z, et al. Sci Adv, 2020 Feb. PMID 32095531, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAPPC8 modulates autophagy and secretory trafficking and is required for TBC1D14 to bind TRAPPIII.
    Title: TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
  2. Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8.
    Title: The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of trafficking protein particle complex 8 (TRAPPC8) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1012, MGC71660

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII vesicle coating NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle tethering NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of TRAPP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPIII protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPPIII protein complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
trafficking protein particle complex subunit 8
Names
general sporulation gene 1 homolog
protein TRS85 homolog
trafficking protein particle complex 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014939.5 → NP_055754.3  trafficking protein particle complex subunit 8

    Status: VALIDATED

    Source sequence(s)
    AC009831, AC022960
    Consensus CDS
    CCDS11901.1
    UniProtKB/Swiss-Prot
    A0JP15, B3KME5, Q9H0L2, Q9Y2L5
    UniProtKB/TrEMBL
    J3QQJ5
    Related
    ENSP00000283351.4, ENST00000283351.10
    Conserved Domains (1) summary
    pfam12739
    Location:160 → 604
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    31829197..31943128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025616.3 → XP_016881105.1  trafficking protein particle complex subunit 8 isoform X5

    UniProtKB/TrEMBL
    J3QQJ5

  2. XM_005258234.4 → XP_005258291.1  trafficking protein particle complex subunit 8 isoform X4

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:158 → 605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  3. XM_005258233.4 → XP_005258290.1  trafficking protein particle complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:158 → 605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  4. XM_017025615.2 → XP_016881104.1  trafficking protein particle complex subunit 8 isoform X3

    UniProtKB/TrEMBL
    J3QQJ5
    Related
    ENSP00000463764.1, ENST00000582539.5

  5. XM_047437353.1 → XP_047293309.1  trafficking protein particle complex subunit 8 isoform X2

  6. XM_005258235.4 → XP_005258292.1  trafficking protein particle complex subunit 8 isoform X10

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:14 → 330
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  7. XM_047437356.1 → XP_047293312.1  trafficking protein particle complex subunit 8 isoform X9

  8. XM_047437355.1 → XP_047293311.1  trafficking protein particle complex subunit 8 isoform X8

  9. XM_047437354.1 → XP_047293310.1  trafficking protein particle complex subunit 8 isoform X7

  10. XM_006722420.5 → XP_006722483.1  trafficking protein particle complex subunit 8 isoform X6

    UniProtKB/TrEMBL
    J3QQJ5
    Conserved Domains (1) summary
    pfam12739
    Location:158 → 605
    TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

  11. XM_047437357.1 → XP_047293313.1  trafficking protein particle complex subunit 8 isoform X11

    Related
    ENSP00000462550.1, ENST00000580104.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    32019706..32133657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318298.1 → XP_054174273.1  trafficking protein particle complex subunit 8 isoform X5

  2. XM_054318297.1 → XP_054174272.1  trafficking protein particle complex subunit 8 isoform X4

  3. XM_054318294.1 → XP_054174269.1  trafficking protein particle complex subunit 8 isoform X1

  4. XM_054318296.1 → XP_054174271.1  trafficking protein particle complex subunit 8 isoform X3

  5. XM_054318295.1 → XP_054174270.1  trafficking protein particle complex subunit 8 isoform X2

  6. XM_054318303.1 → XP_054174278.1  trafficking protein particle complex subunit 8 isoform X10

  7. XM_054318302.1 → XP_054174277.1  trafficking protein particle complex subunit 8 isoform X9

  8. XM_054318301.1 → XP_054174276.1  trafficking protein particle complex subunit 8 isoform X8

  9. XM_054318300.1 → XP_054174275.1  trafficking protein particle complex subunit 8 isoform X7

  10. XM_054318299.1 → XP_054174274.1  trafficking protein particle complex subunit 8 isoform X6

  11. XM_054318304.1 → XP_054174279.1  trafficking protein particle complex subunit 8 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2L5.2 GenPept UniProtKB/Swiss-Prot:Q9Y2L5

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