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SEC31A SEC31 homolog A, COPII coat complex component [ Homo sapiens (human) ]

Gene ID: 22872, updated on 11-Apr-2024

Summary

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Official Symbol
SEC31Aprovided by HGNC
Official Full Name
SEC31 homolog A, COPII coat complex componentprovided by HGNC
Primary source
HGNC:HGNC:17052
See related
Ensembl:ENSG00000138674 MIM:610257; AllianceGenome:HGNC:17052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1
Summary
The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in ovary (RPKM 48.8), thyroid (RPKM 42.6) and 25 other tissues See more
Orthologs
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Genomic context

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See SEC31A in Genome Data Viewer
Location:
4q21.22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (82818509..82900569, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86147772..86229788, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83739662..83821722, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stearoyl-CoA desaturase 5 Neighboring gene uncharacterized LOC124900727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15533 Neighboring gene microRNA 575 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:83718175-83718696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83719673-83720390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83720391-83721107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821333-83821852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821853-83822372 Neighboring gene THAP9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 143 Neighboring gene small nucleolar RNA, C/D box 144 Neighboring gene THAP domain containing 9 Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene ReSE screen-validated silencer GRCh37_chr4:83887737-83887940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21667 Neighboring gene RNA, U6 small nuclear 615, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas. Bedwell C, et al. Haematologica, 2011 Feb. PMID 21109691, Free PMC Article
  2. Identification and isolation of differentially expressed genes in osmotically stressed human oral keratinocytes. Kim JH, et al. Arch Oral Biol, 2001 Apr. PMID 11269867
  3. SEC31A mutation affects ER homeostasis, causing a neurological syndrome. Halperin D, et al. J Med Genet, 2019 Mar. PMID 30464055
  4. A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES). Shibata H, et al. J Biol Chem, 2015 Feb 20. PMID 25540196, Free PMC Article
  5. Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium. Helm JR, et al. J Biol Chem, 2014 Aug 22. PMID 25006245, Free PMC Article

See all (128) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We demonstrate through human and Drosophila genetic and in vitro molecular studies, that a severe neurological syndrome is caused by a null mutation in SEC31A, reducing cell viability through enhanced ER-stress response, in line with SEC31A's role in the COP-II complex.
    Title: SEC31A mutation affects ER homeostasis, causing a neurological syndrome.
  2. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion.
    Title: Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.
  3. Results show the crystal structure of the complex between ALG-2 and a peptide of Sec31A and found that the peptide binds to the third hydrophobic pocket (Pocket 3) and that ALG-2 recognizing 2 types of motifs at different hydrophobic surfaces of Sec31A.
    Title: Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2.
  4. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES.
    Title: A new role for annexin A11 in the early secretory pathway via stabilizing Sec31A protein at the endoplasmic reticulum exit sites (ERES).
  5. ALG-2/Sec31A interactions were not required for the localization of Sec31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
    Title: Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.
  6. ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
    Title: ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex.
  7. These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking.
    Title: CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking.
  8. efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures
    Title: Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.
  9. SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas.
    Title: Cytogenetically complex SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas.
  10. t(4;9)(q21;p24) leads to a novel SEC31A-JAK2 fusion in Hodgkin lymphoma
    Title: JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with intracellular COPII vesicle markers Sec31A and Sec13 in neuronal cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough SEC31A

Included gene: THAP9-AS1

Homology

Clone Names

  • KIAA0905, MGC90305, DKFZp686N07171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII-coated vesicle cargo loading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPII vesicle coat NAS
Non-traceable Author Statement
more info
 PubMed 
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum exit site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein transport protein Sec31A
Names
SEC31 homolog A, COPII coating complex component
SEC31-like protein 1
SEC31-related protein A
web1-like protein
yeast Sec31p homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029569.3 RefSeqGene

    Range
    14419..87063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077206.4 → NP_001070674.1  protein transport protein Sec31A isoform 4

    See identical proteins and their annotated locations for NP_001070674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. The encoded isoform (4) has the same N- and C-termini, but is shorter and has a different internal amino acid compared to isoform 1.
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS43244.1
    UniProtKB/Swiss-Prot
    O94979
    Related
    ENSP00000309070.7, ENST00000311785.11
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573 → 696
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  2. NM_001077207.4 → NP_001070675.1  protein transport protein Sec31A isoform 1

    See identical proteins and their annotated locations for NP_001070675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (1). Both variants 5 and 10 encode the same protein.
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3596.1
    UniProtKB/Swiss-Prot
    B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
    Related
    ENSP00000378721.2, ENST00000395310.7
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573 → 696
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  3. NM_001077208.4 → NP_001070676.1  protein transport protein Sec31A isoform 3

    See identical proteins and their annotated locations for NP_001070676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1. Both variants 3 and 9 encode the same isoform (3).
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS47088.1
    UniProtKB/Swiss-Prot
    O94979
    Related
    ENSP00000424635.1, ENST00000508502.5
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573 → 696
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  4. NM_001191049.2 → NP_001177978.1  protein transport protein Sec31A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' region, resulting in a distinct 5' UTR , use of an upstream in-frame start codon, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (5) is shorter, has a distinct N-terminus, and lacks an internal region, compared to isoform 1
    Source sequence(s)
    AI802473, AK295810, BC039834, BE710081, DA218900, DC342364
    Consensus CDS
    CCDS54773.1
    UniProtKB/Swiss-Prot
    O94979
    Related
    ENSP00000408027.2, ENST00000443462.6
    Conserved Domains (4) summary
    COG2319
    Location:26 → 348
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:65 → 114
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 335
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:568 → 691
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  5. NM_001300744.3 → NP_001287673.1  protein transport protein Sec31A isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two consecutive alternate in-frame exons in the central coding region and an alternate in-frame exon in the 3' coding region, compared to variant 5. The encoded isoform (6) has the same N- and C-termini, but is shorter and has an alternate internal amino acid compared to isoform 1.
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS75155.1
    UniProtKB/Swiss-Prot
    O94979
    Related
    ENSP00000426886.1, ENST00000513858.5
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534 → 657
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  6. NM_001300745.3 → NP_001287674.1  protein transport protein Sec31A isoform 7

    See identical proteins and their annotated locations for NP_001287674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two consecutive alternate in-frame exons in the central coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (7) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS75156.1
    UniProtKB/Swiss-Prot
    O94979
    Related
    ENSP00000424451.1, ENST00000505984.5
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534 → 657
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  7. NM_001318119.2 → NP_001305048.1  protein transport protein Sec31A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks 3 nucleotides in its 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1. Both variants 3 and 9 encode the same isoform (3).
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS47088.1
    UniProtKB/Swiss-Prot
    O94979
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573 → 696
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  8. NM_001318120.2 → NP_001305049.1  protein transport protein Sec31A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Both variants 5 and 10 encode the same protein (isoform 1). This variant is a read-through transcript between the upstream non-coding THAP9-AS1 locus (GeneID:100499177) and the downstream SEC31A locus (GeneID:22872).
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3596.1
    UniProtKB/Swiss-Prot
    B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
    Related
    ENSP00000347329.2, ENST00000355196.6
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:573 → 696
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  9. NM_001400154.1 → NP_001387083.1  protein transport protein Sec31A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS93555.1
    UniProtKB/TrEMBL
    D6REX3

  10. NM_001400155.1 → NP_001387084.1  protein transport protein Sec31A isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS93555.1
    UniProtKB/TrEMBL
    D6REX3
    Related
    ENSP00000421633.1, ENST00000505472.5

  11. NM_001400156.1 → NP_001387085.1  protein transport protein Sec31A isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  12. NM_001400157.1 → NP_001387086.1  protein transport protein Sec31A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  13. NM_001400158.1 → NP_001387087.1  protein transport protein Sec31A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  14. NM_001400159.1 → NP_001387088.1  protein transport protein Sec31A isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  15. NM_001400160.1 → NP_001387089.1  protein transport protein Sec31A isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  16. NM_001400161.1 → NP_001387090.1  protein transport protein Sec31A isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  17. NM_001400162.1 → NP_001387091.1  protein transport protein Sec31A isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  18. NM_001400164.1 → NP_001387093.1  protein transport protein Sec31A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3596.1
    UniProtKB/Swiss-Prot
    B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
    Related
    ENSP00000400926.1, ENST00000448323.5

  19. NM_001400165.1 → NP_001387094.1  protein transport protein Sec31A isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  20. NM_001400166.1 → NP_001387095.1  protein transport protein Sec31A isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3596.1
    UniProtKB/Swiss-Prot
    B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06

  21. NM_001400167.1 → NP_001387096.1  protein transport protein Sec31A isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  22. NM_001400168.1 → NP_001387097.1  protein transport protein Sec31A isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  23. NM_001400180.1 → NP_001387109.1  protein transport protein Sec31A isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  24. NM_001400184.1 → NP_001387113.1  protein transport protein Sec31A isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  25. NM_001400186.1 → NP_001387115.1  protein transport protein Sec31A isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  26. NM_001400188.1 → NP_001387117.1  protein transport protein Sec31A isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  27. NM_001400190.1 → NP_001387119.1  protein transport protein Sec31A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS47088.1

  28. NM_001400191.1 → NP_001387120.1  protein transport protein Sec31A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS47088.1

  29. NM_001400193.1 → NP_001387122.1  protein transport protein Sec31A isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS47088.1

  30. NM_001400194.1 → NP_001387123.1  protein transport protein Sec31A isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  31. NM_001400197.1 → NP_001387126.1  protein transport protein Sec31A isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  32. NM_001400198.1 → NP_001387127.1  protein transport protein Sec31A isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  33. NM_001400200.1 → NP_001387129.1  protein transport protein Sec31A isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  34. NM_001400202.1 → NP_001387131.1  protein transport protein Sec31A isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  35. NM_001400203.1 → NP_001387132.1  protein transport protein Sec31A isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  36. NM_001400204.1 → NP_001387133.1  protein transport protein Sec31A isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  37. NM_001400205.1 → NP_001387134.1  protein transport protein Sec31A isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  38. NM_001400206.1 → NP_001387135.1  protein transport protein Sec31A isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  39. NM_001400207.1 → NP_001387136.1  protein transport protein Sec31A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3597.1

  40. NM_001400208.1 → NP_001387137.1  protein transport protein Sec31A isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  41. NM_001400209.1 → NP_001387138.1  protein transport protein Sec31A isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3597.1

  42. NM_001400210.1 → NP_001387139.1  protein transport protein Sec31A isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  43. NM_001400211.1 → NP_001387140.1  protein transport protein Sec31A isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  44. NM_001400212.1 → NP_001387141.1  protein transport protein Sec31A isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  45. NM_001400213.1 → NP_001387142.1  protein transport protein Sec31A isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS75156.1

  46. NM_001400214.1 → NP_001387143.1  protein transport protein Sec31A isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  47. NM_001400215.1 → NP_001387144.1  protein transport protein Sec31A isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  48. NM_001400216.1 → NP_001387145.1  protein transport protein Sec31A isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  49. NM_001400217.1 → NP_001387146.1  protein transport protein Sec31A isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS43244.1
    Related
    ENSP00000426569.1, ENST00000509142.5

  50. NM_001400218.1 → NP_001387147.1  protein transport protein Sec31A isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  51. NM_001400219.1 → NP_001387148.1  protein transport protein Sec31A isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469

  52. NM_001400220.1 → NP_001387149.1  protein transport protein Sec31A isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Related
    ENSP00000425999.1, ENST00000508479.5

  53. NM_001400221.1 → NP_001387150.1  protein transport protein Sec31A isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    UniProtKB/TrEMBL
    A0A1S5UZ19

  54. NM_001400222.1 → NP_001387151.1  protein transport protein Sec31A isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    UniProtKB/TrEMBL
    A0A1S5UZ19

  55. NM_001400223.1 → NP_001387152.1  protein transport protein Sec31A isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS75155.1
    Related
    ENSP00000421464.1, ENST00000500777.6

  56. NM_001400224.1 → NP_001387153.1  protein transport protein Sec31A isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC021105, AC108469
    Related
    ENSP00000264405.5, ENST00000264405.9

  57. NM_016211.5 → NP_057295.2  protein transport protein Sec31A isoform 2

    See identical proteins and their annotated locations for NP_057295.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons in the central coding region, compared to variant 5. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AC021105, AC108469
    Consensus CDS
    CCDS3597.1
    Related
    ENSP00000337602.5, ENST00000348405.8
    Conserved Domains (4) summary
    COG2319
    Location:31 → 353
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:13 → 65
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:84 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl14807
    Location:534 → 657
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    82818509..82900569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    86147772..86229788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014933.3: Suppressed sequence

    Description
    NM_014933.3: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94979.3 GenPept UniProtKB/Swiss-Prot:O94979

Gene LinkOut

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