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ADGRL1 adhesion G protein-coupled receptor L1 [ Homo sapiens (human) ]

Gene ID: 22859, updated on 11-Apr-2024

Summary

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Official Symbol
ADGRL1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L1provided by HGNC
Primary source
HGNC:HGNC:20973
See related
Ensembl:ENSG00000072071 MIM:616416; AllianceGenome:HGNC:20973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL1; LEC2; CIRL1; LPHN1; DEDBANP
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Expression
Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See ADGRL1 in Genome Data Viewer
Location:
19p13.12
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14147743..14206169, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14274383..14332836, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14258555..14316981, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14223743-14224430 Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10234 Neighboring gene uncharacterized LOC124904642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14155 Neighboring gene small integral membrane protein 46 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14156 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14247764-14248390 Neighboring gene Sharpr-MPRA regulatory region 12148 Neighboring gene ADGRL1 antisense RNA 1 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14258690-14259433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14278263-14278762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:14320437-14320936 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:14328052-14328362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14332061-14332584 Neighboring gene RNA, 7SL, cytoplasmic 231, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10241 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14360564-14361081 Neighboring gene MPRA-validated peak3380 silencer Neighboring gene MPRA-validated peak3381 silencer Neighboring gene Sharpr-MPRA regulatory region 1520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14408885-14409384 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:14421820-14422074 Neighboring gene long intergenic non-protein coding RNA 1841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14429209-14429710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14429711-14430210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14444577-14445252 Neighboring gene MPRA-validated peak3382 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14449292-14449792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14449793-14450293 Neighboring gene long intergenic non-protein coding RNA 1842

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways. Ovando-Zambrano JC, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31339586
  2. Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression. Sakhnevych SS, et al. Cell Mol Immunol, 2018 Nov. PMID 29907881, Free PMC Article
  3. Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells. Sumbayev VV, et al. Oncotarget, 2016 Jul 19. PMID 27322212, Free PMC Article
  4. Association of the subunits of the calcium-independent receptor of α-latrotoxin. Serova OV, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20971062
  5. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model. Vitobello A, et al. Am J Hum Genet, 2022 Aug 4. PMID 35907405, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
    Title: ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
  2. results suggest that SSB splicing selectively affects the duality of LPHN1 signaling toward opposing cAMP pathways
    Title: Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.
  3. Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
    Title: Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
  4. These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction.
    Title: Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
  5. alterations in latrophilin expression occur in AML cells expressing P-gp
    Title: Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.
  6. Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia
    Title: Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells.
  7. A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma.
    Title: Latrophilin receptors: novel bronchodilator targets in asthma.
  8. Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW]
    Title: Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.
  9. In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex.
    Title: Association of the subunits of the calcium-independent receptor of α-latrotoxin.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Developmental delay, behavioral abnormalities, and neuropsychiatric disorders
MedGen: C5774224 OMIM: 620065 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables latrotoxin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables latrotoxin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor L1
Names
CIRL-1
calcium-independent alpha-latrotoxin receptor 1
latrophilin-1
lectomedin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008701.3 → NP_001008701.1  adhesion G protein-coupled receptor L1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001008701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB020628, AF307079, BC002974, BC072445
    Consensus CDS
    CCDS32928.1
    UniProtKB/Swiss-Prot
    O94910, Q96IE7, Q9BU07, Q9HAR3
    Related
    ENSP00000340688.5, ENST00000340736.10
    Conserved Domains (8) summary
    smart00303
    Location:798 → 850
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476 → 539
    HormR; Domain present in hormone receptors
    PHA03247
    Location:398 → 482
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:857 → 1114
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1113 → 1474
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:549 → 774
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

  2. NM_014921.5 → NP_055736.2  adhesion G protein-coupled receptor L1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055736.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AB020628, AF307079, BC002974, BC072445
    Consensus CDS
    CCDS12307.1
    UniProtKB/Swiss-Prot
    O94910
    Related
    ENSP00000355328.2, ENST00000361434.8
    Conserved Domains (8) summary
    smart00303
    Location:793 → 845
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 465
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:852 → 1109
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1108 → 1469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 769
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    14147743..14206169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438418.1 → XP_047294374.1  adhesion G protein-coupled receptor L1 isoform X9

  2. XM_005259818.4 → XP_005259875.1  adhesion G protein-coupled receptor L1 isoform X5

    See identical proteins and their annotated locations for XP_005259875.1

    Conserved Domains (8) summary
    smart00303
    Location:793 → 845
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:471 → 534
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 465
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:852 → 1109
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1108 → 1493
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:544 → 769
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  3. XM_011527798.3 → XP_011526100.1  adhesion G protein-coupled receptor L1 isoform X3

    See identical proteins and their annotated locations for XP_011526100.1

    Conserved Domains (8) summary
    smart00303
    Location:800 → 852
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:478 → 541
    HormR; Domain present in hormone receptors
    PHA03247
    Location:393 → 497
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:859 → 1116
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1115 → 1500
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:551 → 776
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:137 → 393
    OLF; Olfactomedin-like domain

  4. XM_011527796.3 → XP_011526098.1  adhesion G protein-coupled receptor L1 isoform X2

    See identical proteins and their annotated locations for XP_011526098.1

    Conserved Domains (8) summary
    smart00303
    Location:805 → 857
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:483 → 546
    HormR; Domain present in hormone receptors
    PHA03247
    Location:398 → 502
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:864 → 1121
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1120 → 1505
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:556 → 781
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:142 → 398
    OLF; Olfactomedin-like domain

  5. XM_047438417.1 → XP_047294373.1  adhesion G protein-coupled receptor L1 isoform X8

  6. XM_017026477.2 → XP_016881966.1  adhesion G protein-coupled receptor L1 isoform X4

    Conserved Domains (8) summary
    smart00303
    Location:799 → 851
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:477 → 540
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 471
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:858 → 1115
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1114 → 1499
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:550 → 775
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  7. XM_017026479.2 → XP_016881968.1  adhesion G protein-coupled receptor L1 isoform X7

  8. XM_017026478.2 → XP_016881967.1  adhesion G protein-coupled receptor L1 isoform X6

    Conserved Domains (8) summary
    smart00303
    Location:806 → 858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484 → 547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 537
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:865 → 1122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1121 → 1482
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557 → 782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  9. XM_017026475.2 → XP_016881964.1  adhesion G protein-coupled receptor L1 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:806 → 858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484 → 547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 503
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:865 → 1122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1121 → 1506
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557 → 782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  10. XM_047438415.1 → XP_047294371.1  adhesion G protein-coupled receptor L1 isoform X5

  11. XM_017026476.2 → XP_016881965.1  adhesion G protein-coupled receptor L1 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:806 → 858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484 → 547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 503
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:865 → 1122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1121 → 1506
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557 → 782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  12. XM_047438416.1 → XP_047294372.1  adhesion G protein-coupled receptor L1 isoform X5

  13. XM_047438413.1 → XP_047294369.1  adhesion G protein-coupled receptor L1 isoform X1

  14. XM_047438414.1 → XP_047294370.1  adhesion G protein-coupled receptor L1 isoform X3

  15. XM_024451420.2 → XP_024307188.1  adhesion G protein-coupled receptor L1 isoform X1

    Conserved Domains (8) summary
    smart00303
    Location:806 → 858
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:484 → 547
    HormR; Domain present in hormone receptors
    PHA03247
    Location:399 → 503
    PHA03247; large tegument protein UL36; Provisional
    cd16007
    Location:865 → 1122
    7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:48 → 128
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1121 → 1506
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:557 → 782
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl02549
    Location:143 → 399
    OLF; Olfactomedin-like domain

  16. XM_047438419.1 → XP_047294375.1  adhesion G protein-coupled receptor L1 isoform X12

  17. XM_017026480.2 → XP_016881969.2  adhesion G protein-coupled receptor L1 isoform X11

  18. XM_011527801.3 → XP_011526103.2  adhesion G protein-coupled receptor L1 isoform X10

  19. XM_017026481.2 → XP_016881970.1  adhesion G protein-coupled receptor L1 isoform X13

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160022.1 Reference GRCh38.p14 PATCHES

    Range
    359902..418328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332684.1 → XP_054188659.1  adhesion G protein-coupled receptor L1 isoform X9

  2. XM_054332679.1 → XP_054188654.1  adhesion G protein-coupled receptor L1 isoform X5

  3. XM_054332675.1 → XP_054188650.1  adhesion G protein-coupled receptor L1 isoform X3

  4. XM_054332674.1 → XP_054188649.1  adhesion G protein-coupled receptor L1 isoform X2

  5. XM_054332683.1 → XP_054188658.1  adhesion G protein-coupled receptor L1 isoform X8

  6. XM_054332677.1 → XP_054188652.1  adhesion G protein-coupled receptor L1 isoform X4

  7. XM_054332682.1 → XP_054188657.1  adhesion G protein-coupled receptor L1 isoform X7

  8. XM_054332681.1 → XP_054188656.1  adhesion G protein-coupled receptor L1 isoform X6

  9. XM_054332670.1 → XP_054188645.1  adhesion G protein-coupled receptor L1 isoform X1

  10. XM_054332678.1 → XP_054188653.1  adhesion G protein-coupled receptor L1 isoform X5

  11. XM_054332672.1 → XP_054188647.1  adhesion G protein-coupled receptor L1 isoform X1

  12. XM_054332680.1 → XP_054188655.1  adhesion G protein-coupled receptor L1 isoform X5

  13. XM_054332673.1 → XP_054188648.1  adhesion G protein-coupled receptor L1 isoform X1

  14. XM_054332676.1 → XP_054188651.1  adhesion G protein-coupled receptor L1 isoform X3

  15. XM_054332671.1 → XP_054188646.1  adhesion G protein-coupled receptor L1 isoform X1

  16. XM_054332687.1 → XP_054188662.1  adhesion G protein-coupled receptor L1 isoform X12

  17. XM_054332686.1 → XP_054188661.1  adhesion G protein-coupled receptor L1 isoform X11

  18. XM_054332685.1 → XP_054188660.1  adhesion G protein-coupled receptor L1 isoform X10

  19. XM_054332688.1 → XP_054188663.1  adhesion G protein-coupled receptor L1 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    14274383..14332836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320219.1 → XP_054176194.1  adhesion G protein-coupled receptor L1 isoform X9

  2. XM_054320214.1 → XP_054176189.1  adhesion G protein-coupled receptor L1 isoform X5

  3. XM_054320210.1 → XP_054176185.1  adhesion G protein-coupled receptor L1 isoform X3

  4. XM_054320209.1 → XP_054176184.1  adhesion G protein-coupled receptor L1 isoform X2

  5. XM_054320218.1 → XP_054176193.1  adhesion G protein-coupled receptor L1 isoform X8

  6. XM_054320212.1 → XP_054176187.1  adhesion G protein-coupled receptor L1 isoform X4

  7. XM_054320217.1 → XP_054176192.1  adhesion G protein-coupled receptor L1 isoform X7

  8. XM_054320216.1 → XP_054176191.1  adhesion G protein-coupled receptor L1 isoform X6

  9. XM_054320205.1 → XP_054176180.1  adhesion G protein-coupled receptor L1 isoform X1

  10. XM_054320213.1 → XP_054176188.1  adhesion G protein-coupled receptor L1 isoform X5

  11. XM_054320207.1 → XP_054176182.1  adhesion G protein-coupled receptor L1 isoform X1

  12. XM_054320215.1 → XP_054176190.1  adhesion G protein-coupled receptor L1 isoform X5

  13. XM_054320208.1 → XP_054176183.1  adhesion G protein-coupled receptor L1 isoform X1

  14. XM_054320211.1 → XP_054176186.1  adhesion G protein-coupled receptor L1 isoform X3

  15. XM_054320206.1 → XP_054176181.1  adhesion G protein-coupled receptor L1 isoform X1

  16. XM_054320222.1 → XP_054176197.1  adhesion G protein-coupled receptor L1 isoform X12

  17. XM_054320221.1 → XP_054176196.1  adhesion G protein-coupled receptor L1 isoform X11

  18. XM_054320220.1 → XP_054176195.1  adhesion G protein-coupled receptor L1 isoform X10

  19. XM_054320223.1 → XP_054176198.1  adhesion G protein-coupled receptor L1 isoform X13

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94910.1 GenPept UniProtKB/Swiss-Prot:O94910

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