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Prrc2b proline-rich coiled-coil 2B [ Mus musculus (house mouse) ]

Gene ID: 227723, updated on 28-Oct-2024

Summary

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Official Symbol
Prrc2bprovided by MGI
Official Full Name
proline-rich coiled-coil 2Bprovided by MGI
Primary source
MGI:MGI:1923304
See related
Ensembl:ENSMUSG00000039262 AllianceGenome:MGI:1923304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bat2l; Bat2l1; mKIAA0515; D430039P21; 5830434P21Rik
Summary
Acts upstream of or within in utero embryonic development. Is expressed in nervous system and sensory organ. Orthologous to human PRRC2B (proline rich coiled-coil 2B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 35.1), ovary adult (RPKM 32.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prrc2b in Genome Data Viewer
Location:
2 B; 2 22.05 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32041002..32124549)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32151031..32234537)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 78, member A Neighboring gene predicted gene, 33126 Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene STARR-seq mESC enhancer starr_04169 Neighboring gene VISTA enhancer mm194 Neighboring gene STARR-seq mESC enhancer starr_04172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32011222-32011331 Neighboring gene STARR-seq mESC enhancer starr_04177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32023467-32023668 Neighboring gene STARR-seq mESC enhancer starr_04183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32036927-32037171 Neighboring gene predicted gene, 22192 Neighboring gene predicted gene, 25632 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10094 Neighboring gene uridine-cytidine kinase 1 Neighboring gene 60S ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice. Li S, et al. Adv Sci (Weinh), 2023 Sep. PMID 37395402, Free PMC Article
  2. PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Zhang Y, et al. Cell Rep, 2024 Mar 26. PMID 38507412
  3. Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Martinez-Mayer J, et al. Genome Med, 2024 May 31. PMID 38822427, Free PMC Article
  4. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
  5. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice.
    Title: The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein PRRC2B
Names
HLA-B-associated transcript 2-like 1
proline-rich coiled-coil protein 2B
protein BAT2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159634.1 → NP_001153106.1  protein PRRC2B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147677, BC055116, BP753788
    Consensus CDS
    CCDS50565.1
    UniProtKB/TrEMBL
    F8WHT3
    Related
    ENSMUSP00000064892.9, ENSMUST00000069817.15
    Conserved Domains (2) summary
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus
    pfam07223
    Location:1932 → 2189
    DUF1421; Protein of unknown function (DUF1421)

  2. NM_172661.3 → NP_766249.2  protein PRRC2B isoform 2

    See identical proteins and their annotated locations for NP_766249.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, lacks an alternate exon in the 3' coding region that results in a frameshift of the C-terminus, and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, includes an extra amino acid, and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK147677, BC055116, BP753788
    Consensus CDS
    CCDS15907.1
    UniProtKB/Swiss-Prot
    A2AN31, Q7TPM1, Q8C755
    UniProtKB/TrEMBL
    F7AYW2
    Related
    ENSMUSP00000035734.8, ENSMUST00000036691.14
    Conserved Domains (2) summary
    pfam03153
    Location:1261 → 1441
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32041002..32124549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497948.5 → XP_006498011.1  protein PRRC2B isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:1741 → 2176
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  2. XM_006497951.5 → XP_006498014.1  protein PRRC2B isoform X4

    Conserved Domains (2) summary
    pfam09606
    Location:1802 → 2123
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  3. XM_030249906.2 → XP_030105766.1  protein PRRC2B isoform X5

    Conserved Domains (2) summary
    pfam09606
    Location:1801 → 2122
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  4. XM_006497949.5 → XP_006498012.1  protein PRRC2B isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:1711 → 2146
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  5. XM_006497950.5 → XP_006498013.1  protein PRRC2B isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:1710 → 2145
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  6. XM_006497952.5 → XP_006498015.1  protein PRRC2B isoform X6

    UniProtKB/TrEMBL
    F7AYW2
    Related
    ENSMUSP00000116429.2, ENSMUST00000132459.8
    Conserved Domains (2) summary
    PHA03247
    Location:1054 → 1489
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  7. XM_006497953.5 → XP_006498016.1  protein PRRC2B isoform X7

    See identical proteins and their annotated locations for XP_006498016.1

    UniProtKB/TrEMBL
    F7AYW2
    Conserved Domains (2) summary
    PHA03247
    Location:1053 → 1488
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  8. XM_030249910.2 → XP_030105770.1  protein PRRC2B isoform X8

    UniProtKB/TrEMBL
    F7AYW2
    Conserved Domains (2) summary
    PHA03247
    Location:1024 → 1459
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  9. XM_030249911.2 → XP_030105771.1  protein PRRC2B isoform X9

    UniProtKB/TrEMBL
    F7AYW2
    Conserved Domains (2) summary
    PHA03247
    Location:1023 → 1458
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  10. XM_030249897.2 → XP_030105757.1  protein PRRC2B isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:1741 → 2176
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPM1.1 GenPept UniProtKB/Swiss-Prot:Q7TPM1

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