Snapc4 small nuclear RNA activating complex, polypeptide 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snapc4provided by MGI
Official Full Name: small nuclear RNA activating complex, polypeptide 4provided by MGI
Primary source: MGI:MGI:2443935
See related: Ensembl:ENSMUSG00000036281 AllianceGenome:MGI:2443935
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730436L13Rik
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity; RNA polymerase III general transcription initiation factor activity; and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of snRNA-activating protein complex. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human SNAPC4 (small nuclear RNA activating complex polypeptide 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 8.1), genital fat pad adult (RPKM 7.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 18.87 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26252777..26270666, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26362765..26380661, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in snRNA transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in snRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in snRNA transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in snRNA transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of snRNA-activating protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of snRNA-activating protein complex	ISO Inferred from Sequence Orthology more info
part_of snRNA-activating protein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: snRNA-activating protein complex subunit 4

Names: SNAPc subunit 4; snRNA-activating protein complex 190 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290419.2 → NP_001277348.1 snRNA-activating protein complex subunit 4 isoform b

See identical proteins and their annotated locations for NP_001277348.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AL732541

UniProtKB/TrEMBL

A2AIV6

Related

ENSMUST00000149850.8

Conserved Domains (5) summary

smart00717
Location:311 → 358

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:365 → 406

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam13921
Location:314 → 374

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl09111
Location:110 → 162

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl21498
Location:172 → 215

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001406731.1 → NP_001393660.1 snRNA-activating protein complex subunit 4 3

Status: VALIDATED

Source sequence(s)

AL732541

UniProtKB/Swiss-Prot

Q6PGG7, Q80UG9, Q810L1, Q8BP86
NM_001406732.1 → NP_001393661.1 snRNA-activating protein complex subunit 4 3

Status: VALIDATED

Source sequence(s)

AL732541

UniProtKB/Swiss-Prot

Q6PGG7, Q80UG9, Q810L1, Q8BP86
NM_001406733.1 → NP_001393662.1 snRNA-activating protein complex subunit 4 isoform a

Status: VALIDATED

Source sequence(s)

AL732541
NM_001406734.1 → NP_001393663.1 snRNA-activating protein complex subunit 4 isoform 4

Status: VALIDATED

Source sequence(s)

AL732541
NM_001406735.1 → NP_001393664.1 snRNA-activating protein complex subunit 4 isoform 5

Status: VALIDATED

Source sequence(s)

AL732541
NM_001406736.1 → NP_001393665.1 snRNA-activating protein complex subunit 4 isoform 6

Status: VALIDATED

Source sequence(s)

AL732541
NM_001406737.1 → NP_001393666.1 snRNA-activating protein complex subunit 4 isoform 6

Status: VALIDATED

Source sequence(s)

AL732541
NM_001406738.1 → NP_001393667.1 snRNA-activating protein complex subunit 4 isoform 7

Status: VALIDATED

Source sequence(s)

AL732541
NM_001406739.1 → NP_001393668.1 snRNA-activating protein complex subunit 4 isoform 7

Status: VALIDATED

Source sequence(s)

AL732541
NM_172339.5 → NP_758842.1 snRNA-activating protein complex subunit 4 isoform a

See identical proteins and their annotated locations for NP_758842.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).

Source sequence(s)

AL732541

Consensus CDS

CCDS15802.1

UniProtKB/TrEMBL

A2AIV6

Related

ENSMUSP00000041767.5, ENSMUST00000035427.11

Conserved Domains (5) summary

smart00717
Location:401 → 448

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:455 → 496

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam13921
Location:404 → 464

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl09111
Location:200 → 252

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl21498
Location:262 → 305

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

26252777..26270666 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239065.4 → XP_011237367.1 snRNA-activating protein complex subunit 4 isoform X2

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:461 → 504

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:815 → 1174

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:200 → 407

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:412 → 472

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_011239064.4 → XP_011237366.1 snRNA-activating protein complex subunit 4 isoform X1

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:461 → 504

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:815 → 1174

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:200 → 407

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:412 → 472

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_036160757.1 → XP_036016650.1 snRNA-activating protein complex subunit 4 isoform X14

Conserved Domains (1) summary

PHA03247
Location:124 → 494

PHA03247; large tegument protein UL36; Provisional
XM_030249765.2 → XP_030105625.1 snRNA-activating protein complex subunit 4 isoform X14

Conserved Domains (1) summary

PHA03247
Location:124 → 494

PHA03247; large tegument protein UL36; Provisional
XM_036160749.1 → XP_036016642.1 snRNA-activating protein complex subunit 4 isoform X10

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:301 → 344

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:634 → 993

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:2 → 284

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:252 → 312

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_030249744.2 → XP_030105604.1 snRNA-activating protein complex subunit 4 isoform X7

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:363 → 406

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:696 → 1055

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:102 → 309

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:314 → 374

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_030249743.2 → XP_030105603.1 snRNA-activating protein complex subunit 4 isoform X6

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:363 → 406

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:717 → 1076

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:102 → 309

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:314 → 374

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_036160748.1 → XP_036016641.1 snRNA-activating protein complex subunit 4 isoform X9

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:301 → 344

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:655 → 1014

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:2 → 284

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:252 → 312

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_011239066.4 → XP_011237368.1 snRNA-activating protein complex subunit 4 isoform X3

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:453 → 496

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:807 → 1166

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:192 → 399

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:404 → 464

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_036160746.1 → XP_036016639.1 snRNA-activating protein complex subunit 4 isoform X9

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:301 → 344

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:655 → 1014

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:2 → 284

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:252 → 312

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_030249751.2 → XP_030105611.1 snRNA-activating protein complex subunit 4 isoform X11

Conserved Domains (4) summary

smart00717
Location:98 → 141

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:452 → 811

PHA03247; large tegument protein UL36; Provisional

pfam13921
Location:49 → 109

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl21498
Location:18 → 57

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_011239069.4 → XP_011237371.1 snRNA-activating protein complex subunit 4 isoform X9

See identical proteins and their annotated locations for XP_011237371.1

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:301 → 344

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:655 → 1014

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:2 → 284

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:252 → 312

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_011239070.4 → XP_011237372.1 snRNA-activating protein complex subunit 4 isoform X9

See identical proteins and their annotated locations for XP_011237372.1

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:301 → 344

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:655 → 1014

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:2 → 284

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:252 → 312

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_011239067.4 → XP_011237369.1 snRNA-activating protein complex subunit 4 isoform X6

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:363 → 406

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:717 → 1076

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:102 → 309

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:314 → 374

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_011239068.3 → XP_011237370.1 snRNA-activating protein complex subunit 4 isoform X8

UniProtKB/TrEMBL

A2AIV6

Conserved Domains (4) summary

smart00717
Location:314 → 357

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

PHA03247
Location:668 → 1027

PHA03247; large tegument protein UL36; Provisional

COG5147
Location:53 → 260

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:265 → 325

Myb_DNA-bind_6; Myb-like DNA-binding domain