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Zscan12 zinc finger and SCAN domain containing 12 [ Mus musculus (house mouse) ]

Gene ID: 22758, updated on 2-Nov-2024

Summary

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Official Symbol
Zscan12provided by MGI
Official Full Name
zinc finger and SCAN domain containing 12provided by MGI
Primary source
MGI:MGI:1099444
See related
Ensembl:ENSMUSG00000036721 AllianceGenome:MGI:1099444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp96; FPM315; zfp-96; mKIAA0426; 2510038J07Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and thymus primordium. Orthologous to human ZSCAN12 (zinc finger and SCAN domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 3.4), testis adult (RPKM 3.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Zscan12 in Genome Data Viewer
Location:
13 A3.1; 13 7.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21546982..21556472)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21362820..21372302)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA methionine 13 (anticodon CAT) Neighboring gene olfactory receptor family 2 subfamily B member 28 Neighboring gene zinc finger with KRAB and SCAN domains 3 Neighboring gene STARR-seq mESC enhancer starr_33849 Neighboring gene STARR-positive B cell enhancer ABC_E10783 Neighboring gene microRNA 6942 Neighboring gene piggyBac transposable element derived 1 Neighboring gene RIKEN cDNA 4930470G03 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Yokoyama M, et al. Biochim Biophys Acta, 1997 Jul 17. PMID 9256059
  2. Three novel spermatogenesis-specific zinc finger genes. Weissig H, et al. FEBS Lett, 2003 Jul 17. PMID 12860387
  3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning and characterization of its expression during spermatogenesis
    Title: Three novel spermatogenesis-specific zinc finger genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 12
Names
zinc finger protein 96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016684.3 → NP_057893.2  zinc finger and SCAN domain-containing protein 12

    See identical proteins and their annotated locations for NP_057893.2

    Status: VALIDATED

    Source sequence(s)
    BX001068
    Consensus CDS
    CCDS26273.1
    UniProtKB/Swiss-Prot
    Q8R0D8, Q9Z1D7
    Related
    ENSMUSP00000153548.2, ENSMUST00000225545.2
    Conserved Domains (4) summary
    smart00431
    Location:42 → 148
    SCAN; leucine rich region
    COG5048
    Location:231 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 466
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    21546982..21556472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247246.2 → XP_030103106.1  zinc finger and SCAN domain-containing protein 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8R0D8, Q9Z1D7
    Related
    ENSMUSP00000058904.7, ENSMUST00000053293.14
    Conserved Domains (4) summary
    smart00431
    Location:42 → 148
    SCAN; leucine rich region
    COG5048
    Location:231 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 466
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006516660.3 → XP_006516723.1  zinc finger and SCAN domain-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006516723.1

    UniProtKB/Swiss-Prot
    Q8R0D8, Q9Z1D7
    Conserved Domains (4) summary
    smart00431
    Location:42 → 148
    SCAN; leucine rich region
    COG5048
    Location:231 → 437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271 → 291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:446 → 466
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1D7.2 GenPept UniProtKB/Swiss-Prot:Q9Z1D7

Gene LinkOut

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