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Farp2 FERM, RhoGEF and pleckstrin domain protein 2 [ Mus musculus (house mouse) ]

Gene ID: 227377, updated on 2-Nov-2024

Summary

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Official Symbol
Farp2provided by MGI
Official Full Name
FERM, RhoGEF and pleckstrin domain protein 2provided by MGI
Primary source
MGI:MGI:2385126
See related
Ensembl:ENSMUSG00000034066 AllianceGenome:MGI:2385126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fir; mKIAA0793; D030026M03Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including osteoclast differentiation; podosome assembly; and regulation of integrin activation. Acts upstream of or within hair cycle process. Predicted to be located in cytoplasm. Is expressed in central nervous system; liver; retina; and testis. Orthologous to human FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 5.0), colon adult (RPKM 4.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Farp2 in Genome Data Viewer
Location:
1 D; 1 47.24 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93439826..93549698)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93512104..93621976)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95362466-95362649 Neighboring gene STARR-positive B cell enhancer ABC_E1556 Neighboring gene STARR-positive B cell enhancer ABC_E4336 Neighboring gene septin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4337 Neighboring gene STARR-positive B cell enhancer ABC_E1223 Neighboring gene STARR-seq mESC enhancer starr_01729 Neighboring gene predicted gene, 41920 Neighboring gene STARR-seq mESC enhancer starr_01730 Neighboring gene elongation factor RNA polymerase II-like 3 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95532366-95532549 Neighboring gene serine/threonine kinase 25 (yeast) Neighboring gene BCL2-related ovarian killer Neighboring gene THAP domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_01735

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain. Kawakita A, et al. Brain Res Dev Brain Res, 2003 Sep 10. PMID 12935915
  2. Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1. Su Z, et al. Arterioscler Thromb Vasc Biol, 2009 Jan. PMID 18988887, Free PMC Article
  3. Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements. Takegahara N, et al. FASEB J, 2010 Dec. PMID 20702777
  4. Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. He X, et al. Structure, 2013 Mar 5. PMID 23375260, Free PMC Article
  5. Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis. Danelon V, et al. J Neurosci, 2020 Jul 8. PMID 32499377, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.
    Title: Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.
  2. Findings reveal an integral role of FARP2 for regulation of Rac1 and integrin beta3 throughout podosome rearrangement in osteoclastogenesis.
    Title: Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements.
  3. Confirmed Hdlq14 as a separate independent quantitative trait locus for HDL and narrowed the region to 2 genes, Farp2 and Stk25, with considerable evidence for both.
    Title: Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1.
  4. Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain.
    Title: Developmental regulation of FERM domain including guanine nucleotide exchange factor gene expression in the mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0793

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hair cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron remodeling ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in podosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of integrin activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
FERM, ARHGEF and pleckstrin domain-containing protein 2
Names
FERM domain including RhoGEF
FERM, RhoGEF and pleckstrin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145519.2 → NP_663494.2  FERM, ARHGEF and pleckstrin domain-containing protein 2

    See identical proteins and their annotated locations for NP_663494.2

    Status: VALIDATED

    Source sequence(s)
    AK050860, AK173028, AW912106, BB663505, BI739824, BP770314, BY130680
    Consensus CDS
    CCDS15191.1
    UniProtKB/Swiss-Prot
    E9QJS4, Q3TAP2, Q69ZZ0, Q91VS8
    Related
    ENSMUSP00000112725.2, ENSMUST00000120301.8
    Conserved Domains (9) summary
    smart00295
    Location:45 → 234
    B41; Band 4.1 homologues
    cd00160
    Location:540 → 723
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01220
    Location:752 → 859
    PH1_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 1
    cd13193
    Location:221 → 341
    FERM_C_FARP1-like; FERM domain C-lobe of FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins
    cd13235
    Location:929 → 1026
    PH2_FARP1-like; FERM, RhoGEF and pleckstrin domain-containing protein 1 and related proteins Pleckstrin Homology (PH) domain, repeat 2
    pfam00169
    Location:934 → 1027
    PH; PH domain
    pfam00373
    Location:131 → 234
    FERM_M; FERM central domain
    pfam08736
    Location:333 → 375
    FA; FERM adjacent (FA)
    pfam09379
    Location:48 → 111
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93439826..93549698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VS8.2 GenPept UniProtKB/Swiss-Prot:Q91VS8

Gene LinkOut

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