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Gpr55 G protein-coupled receptor 55 [ Mus musculus (house mouse) ]

Gene ID: 227326, updated on 28-Oct-2024

Summary

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Official Symbol
Gpr55provided by MGI
Official Full Name
G protein-coupled receptor 55provided by MGI
Primary source
MGI:MGI:2685064
See related
Ensembl:ENSMUSG00000049608 AllianceGenome:MGI:2685064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTFL; Gm218; Lpir1
Summary
Predicted to enable cannabinoid receptor activity. Predicted to be involved in several processes, including bone resorption; negative regulation of osteoclast differentiation; and positive regulation of intracellular signal transduction. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; forebrain; neural retina; and retina. Orthologous to human GPR55 (G protein-coupled receptor 55). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 1.4), small intestine adult (RPKM 1.0) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr55 in Genome Data Viewer
Location:
1 C5; 1 43.94 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85860927..85924781, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85933221..85991583, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745 Neighboring gene RIKEN cDNA 4933407L21 gene Neighboring gene STARR-seq mESC enhancer starr_01557 Neighboring gene predicted gene, 41905 Neighboring gene STARR-positive B cell enhancer ABC_E5777 Neighboring gene predicted gene, 53569 Neighboring gene zinc finger protein 617 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. Wu CS, et al. PLoS One, 2013. PMID 23565223, Free PMC Article
  2. Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice. Carey LM, et al. Sci Rep, 2017 Apr 20. PMID 28428628, Free PMC Article
  3. A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity. Hurst K, et al. Hippocampus, 2017 Sep. PMID 28653801, Free PMC Article
  4. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Shi QX, et al. Mol Brain, 2017 Aug 11. PMID 28800762, Free PMC Article
  5. GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR-independent suppression of Na(+)-Ca(2+) exchanger and endoplasmic reticulum Ca(2+) refilling. Bondarenko AI, et al. Vascul Pharmacol, 2017 Feb. PMID 28064014, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Global deletion of G protein-coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and beta-cell turnover.
    Title: Global deletion of G protein-coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β-cell turnover.
  2. GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice.
    Title: GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice.
  3. GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice.
    Title: GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice.
  4. Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome.
    Title: Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome.
  5. Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice.
    Title: Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice.
  6. The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice.
    Title: The neuroprotective effects of GPR55 against hippocampal neuroinflammation and impaired adult neurogenesis in CSDS mice.
  7. Activation of GPR55 attenuates cognitive impairment, oxidative stress, neuroinflammation, and synaptic dysfunction in a streptozotocin-induced Alzheimer's mouse model.
    Title: Activation of GPR55 attenuates cognitive impairment, oxidative stress, neuroinflammation, and synaptic dysfunction in a streptozotocin-induced Alzheimer's mouse model.
  8. Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
    Title: Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
  9. Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation.
    Title: Cannabinoid receptor GPR55 activation blocks nicotine use disorder by regulation of AMPAR phosphorylation.
  10. GPR55 regulates the responsiveness to, but does not dimerise with, alpha1A-adrenoceptors.
    Title: GPR55 regulates the responsiveness to, but does not dimerise with, α(1A)-adrenoceptors.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cannabinoid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cannabinoid receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
  
involved_in bone resorption ISO
Inferred from Sequence Orthology
more info
  
involved_in cannabinoid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033290.3 → NP_001028462.2  G-protein coupled receptor 55

    See identical proteins and their annotated locations for NP_001028462.2

    Status: VALIDATED

    Source sequence(s)
    AC102506, AC107707
    Consensus CDS
    CCDS15115.1
    UniProtKB/Swiss-Prot
    Q3UJF0
    UniProtKB/TrEMBL
    Q14BV9
    Related
    ENSMUSP00000084196.5, ENSMUST00000086975.7
    Conserved Domains (2) summary
    cd14964
    Location:20 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:20 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    85860927..85924781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320337.3 → XP_017175826.1  G-protein coupled receptor 55 isoform X4

    UniProtKB/Swiss-Prot
    Q3UJF0
    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:20 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:20 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_011247986.4 → XP_011246288.1  G-protein coupled receptor 55 isoform X1

    See identical proteins and their annotated locations for XP_011246288.1

    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:48 → 75
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:48 → 333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006529459.5 → XP_006529522.1  G-protein coupled receptor 55 isoform X2

    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:37 → 64
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:37 → 322
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_036164492.1 → XP_036020385.1  G-protein coupled receptor 55 isoform X4

    UniProtKB/Swiss-Prot
    Q3UJF0
    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:20 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:20 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_030253716.2 → XP_030109576.1  G-protein coupled receptor 55 isoform X4

    UniProtKB/Swiss-Prot
    Q3UJF0
    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:20 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:20 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_030253705.2 → XP_030109565.1  G-protein coupled receptor 55 isoform X1

    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:48 → 75
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:48 → 333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. XM_030253706.2 → XP_030109566.1  G-protein coupled receptor 55 isoform X1

    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:48 → 75
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:48 → 333
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  8. XM_030253715.2 → XP_030109575.1  G-protein coupled receptor 55 isoform X3

    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:32 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 317
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  9. XM_030253712.2 → XP_030109572.1  G-protein coupled receptor 55 isoform X2

    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:37 → 64
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:37 → 322
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  10. XM_030253718.2 → XP_030109578.1  G-protein coupled receptor 55 isoform X4

    UniProtKB/Swiss-Prot
    Q3UJF0
    UniProtKB/TrEMBL
    Q14BV9
    Conserved Domains (2) summary
    cd14964
    Location:20 → 47
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:20 → 305
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UJF0.2 GenPept UniProtKB/Swiss-Prot:Q3UJF0

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