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Ino80d INO80 complex subunit D [ Mus musculus (house mouse) ]

Gene ID: 227195, updated on 2-Nov-2024

Summary

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Official Symbol
Ino80dprovided by MGI
Official Full Name
INO80 complex subunit Dprovided by MGI
Primary source
MGI:MGI:3027003
See related
Ensembl:ENSMUSG00000040865 AllianceGenome:MGI:3027003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
7330405I11; A430093A21Rik
Summary
Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be part of Ino80 complex. Predicted to be active in nucleus. Is expressed in several structures, including endocrine gland; gallbladder; genitourinary system; nervous system; and skeletal muscle tissue. Orthologous to human INO80D (INO80 complex subunit D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 7.5), lung adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ino80d in Genome Data Viewer
Location:
1 C2; 1 31.89 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63086960..63153693, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63047801..63114267, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 44468 Neighboring gene predicted gene, 24942 Neighboring gene ribosomal protein S27, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2545 Neighboring gene STARR-seq mESC enhancer starr_01125 Neighboring gene INO80 complex subunit D, opposite strand Neighboring gene STARR-seq mESC enhancer starr_01129 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene STARR-positive B cell enhancer ABC_E1994 Neighboring gene predicted gene, 26457 Neighboring gene eukaryotic translation elongation factor 1 beta 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
INO80 complex subunit D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081436.3 → NP_001074905.1  INO80 complex subunit D isoform 2

    See identical proteins and their annotated locations for NP_001074905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL645685, AL645950
    Consensus CDS
    CCDS35594.1
    UniProtKB/TrEMBL
    B1AT32
    Related
    ENSMUSP00000115332.3, ENSMUST00000153992.3
    Conserved Domains (2) summary
    PRK14971
    Location:65 → 195
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam13891
    Location:337 → 401
    zf-C3Hc3H; Potential DNA-binding domain

  2. NM_001114609.2 → NP_001108081.1  INO80 complex subunit D isoform 1

    See identical proteins and their annotated locations for NP_001108081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform.
    Source sequence(s)
    AL645685, AL645950
    Consensus CDS
    CCDS48277.1
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5
    Related
    ENSMUSP00000119118.3, ENSMUST00000137511.9
    Conserved Domains (2) summary
    PRK14971
    Location:170 → 300
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam13891
    Location:18 → 79
    zf-C3Hc3H; Potential DNA-binding domain

  3. NM_001406701.1 → NP_001393630.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  4. NM_001406702.1 → NP_001393631.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  5. NM_001406703.1 → NP_001393632.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  6. NM_001406704.1 → NP_001393633.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5
    Related
    ENSMUSP00000095325.4, ENSMUST00000097718.10

  7. NM_001406705.1 → NP_001393634.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  8. NM_001406706.1 → NP_001393635.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  9. NM_001406707.1 → NP_001393636.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  10. NM_001406708.1 → NP_001393637.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  11. NM_001406709.1 → NP_001393638.1  INO80 complex subunit D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/Swiss-Prot
    E9Q9Q0, E9QLE8, Q66JY2, Q8BQK5

  12. NM_001406710.1 → NP_001393639.1  INO80 complex subunit D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/TrEMBL
    B1AT32

  13. NM_001406711.1 → NP_001393640.1  INO80 complex subunit D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/TrEMBL
    B1AT32

  14. NM_001406712.1 → NP_001393641.1  INO80 complex subunit D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/TrEMBL
    B1AT32
    Related
    ENSMUSP00000123430.2, ENSMUST00000133236.8

  15. NM_001406713.1 → NP_001393642.1  INO80 complex subunit D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/TrEMBL
    B1AT32

  16. NM_001406714.1 → NP_001393643.1  INO80 complex subunit D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645685, AL645950
    UniProtKB/TrEMBL
    B1AT32

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    63086960..63153693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JY2.4 GenPept UniProtKB/Swiss-Prot:Q66JY2

Gene LinkOut

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