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Kcnq5 potassium voltage-gated channel, subfamily Q, member 5 [ Mus musculus (house mouse) ]

Gene ID: 226922, updated on 18-Sep-2024

Summary

Official Symbol
Kcnq5provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 5provided by MGI
Primary source
MGI:MGI:1924937
See related
Ensembl:ENSMUSG00000028033 AllianceGenome:MGI:1924937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Mgi1; 7730402H11; 9230107O05Rik
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of clathrin coat and voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 3.9), frontal lobe adult (RPKM 3.2) and 9 other tissues See more
Orthologs
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Genomic context

See Kcnq5 in Genome Data Viewer
Location:
1 A4; 1 6.67 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21468623..22032874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21398399..21962650, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:21459459-21459687 Neighboring gene predicted gene, 33147 Neighboring gene KH domain containing 1 pseudogene Neighboring gene KH domain containing 1B Neighboring gene STARR-seq mESC enhancer starr_00409 Neighboring gene STARR-seq mESC enhancer starr_00410 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene STARR-seq mESC enhancer starr_00411 Neighboring gene STARR-seq mESC enhancer starr_00412 Neighboring gene predicted gene, 53539 Neighboring gene STARR-seq mESC enhancer starr_00414 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00415 Neighboring gene STARR-seq mESC enhancer starr_00416 Neighboring gene STARR-seq mESC enhancer starr_00417 Neighboring gene regulating synaptic membrane exocytosis 1 Neighboring gene STARR-seq mESC enhancer starr_00419 Neighboring gene STARR-seq mESC enhancer starr_00422

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily KQT member 5
Names
KQT-like 5
potassium channel subunit alpha KvLQT5
voltage-gated potassium channel subunit Kv7.5
voltage-gated potassium channel type Kv7.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160139.1NP_001153611.1  potassium voltage-gated channel subfamily KQT member 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK147264, AW493240, BE648243, CX239866
    Consensus CDS
    CCDS48230.1
    UniProtKB/TrEMBL
    E9Q9F1, G3UYP4
    Related
    ENSMUSP00000110955.2, ENSMUST00000115300.8
    Conserved Domains (3) summary
    pfam00520
    Location:161359
    Ion_trans; Ion transport protein
    pfam03520
    Location:473660
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:275349
    Ion_trans_2; Ion channel
  2. NM_001310477.1NP_001297406.1  potassium voltage-gated channel subfamily KQT member 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) omits two in-frame coding exons, compared to variant 1, resulting in a shorter protein (isoform 3).
    Source sequence(s)
    AC115920, AC125483, AC131088
    Consensus CDS
    CCDS78554.1
    UniProtKB/TrEMBL
    G3UYG5, G3UYP4
    Related
    ENSMUSP00000134076.2, ENSMUST00000173404.2
    Conserved Domains (3) summary
    pfam00520
    Location:161359
    Ion_trans; Ion transport protein
    pfam03520
    Location:445632
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:275349
    Ion_trans_2; Ion channel
  3. NM_023872.3NP_076361.1  potassium voltage-gated channel subfamily KQT member 5 isoform 2

    See identical proteins and their annotated locations for NP_076361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK147264, AW493240, AY679158, BE648243, CX239866
    Consensus CDS
    CCDS35525.1
    UniProtKB/Swiss-Prot
    Q4QXS5, Q8BSF6, Q9JK45
    UniProtKB/TrEMBL
    G3UYP4
    Related
    ENSMUSP00000029667.7, ENSMUST00000029667.13
    Conserved Domains (2) summary
    pfam00520
    Location:127359
    Ion_trans; Ion transport protein
    pfam03520
    Location:448635
    KCNQ_channel; KCNQ voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    21468623..22032874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164276.1XP_036020169.1  potassium voltage-gated channel subfamily KQT member 5 isoform X1

    UniProtKB/TrEMBL
    G3UYP4
    Conserved Domains (2) summary
    pfam00520
    Location:5229
    Ion_trans; Ion transport protein
    pfam03520
    Location:337524
    KCNQ_channel; KCNQ voltage-gated potassium channel