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Zscan2 zinc finger and SCAN domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 22691, updated on 28-Oct-2024

Summary

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Official Symbol
Zscan2provided by MGI
Official Full Name
zinc finger and SCAN domain containing 2provided by MGI
Primary source
MGI:MGI:99176
See related
Ensembl:ENSMUSG00000038797 AllianceGenome:MGI:99176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp29; Zfp-29
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ZSCAN2 (zinc finger and SCAN domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 7.0), CNS E14 (RPKM 4.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Zscan2 in Genome Data Viewer
Location:
7 D3; 7 45.71 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80510485..80539740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80860737..80878675)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87792406-87792515 Neighboring gene predicted gene 15880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87812125-87812234 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene predicted gene, 18392 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73 Neighboring gene neuromedin B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model. Sánchez Carretero L, et al. PLoS One, 2024. PMID 39172905, Free PMC Article
  2. A novel high throughput screen to identify candidate molecular networks that regulate spermatogenic stem cell functions†. Lord T, et al. Biol Reprod, 2022 Jun 13. PMID 35244684, Free PMC Article
  3. A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis. Denny P, et al. Gene, 1991 Oct 15. PMID 1937051
  4. Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7. Denny P, et al. Mamm Genome, 1995 Sep. PMID 8535085
  5. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
    Title: Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 2
Names
zinc finger protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382511.1 → NP_001369440.1  zinc finger and SCAN domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109257
    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  2. NM_001382512.1 → NP_001369441.1  zinc finger and SCAN domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109257
    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  3. NM_001382513.1 → NP_001369442.1  zinc finger and SCAN domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109257
    Conserved Domains (3) summary
    COG5048
    Location:219 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  4. NM_001382514.1 → NP_001369443.1  zinc finger and SCAN domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109257
    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  5. NM_001382515.1 → NP_001369444.1  zinc finger and SCAN domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109257
    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  6. NM_009553.2 → NP_033579.1  zinc finger and SCAN domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_033579.1

    Status: VALIDATED

    Source sequence(s)
    BC046961
    Consensus CDS
    CCDS21399.1
    UniProtKB/Swiss-Prot
    Q07230
    Related
    ENSMUSP00000042321.8, ENSMUST00000044115.9
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80510485..80539740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540811.4 → XP_006540874.1  zinc finger and SCAN domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540874.1

    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  2. XM_006540808.5 → XP_006540871.1  zinc finger and SCAN domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540871.1

    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  3. XM_006540812.5 → XP_006540875.1  zinc finger and SCAN domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540875.1

    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain

  4. XM_006540810.5 → XP_006540873.1  zinc finger and SCAN domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006540873.1

    UniProtKB/Swiss-Prot
    Q07230
    Conserved Domains (3) summary
    COG5048
    Location:220 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:69 → 131
    SCAN; SCAN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07230.1 GenPept UniProtKB/Swiss-Prot:Q07230

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