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Lpgat1 lysophosphatidylglycerol acyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 226856, updated on 2-Nov-2024

Summary

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Official Symbol
Lpgat1provided by MGI
Official Full Name
lysophosphatidylglycerol acyltransferase 1provided by MGI
Primary source
MGI:MGI:2446186
See related
Ensembl:ENSMUSG00000026623 AllianceGenome:MGI:2446186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPLAT7
Summary
Enables 2-acylglycerol O-acyltransferase activity; 2-acylglycerophosphocholine O-acyltransferase activity; and lysophosphatidylethanolamine acyltransferase activity. Involved in phosphatidylethanolamine acyl-chain remodeling and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in nervous system; nose; respiratory system; salivary gland; and urinary system. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 21.4), genital fat pad adult (RPKM 19.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Lpgat1 in Genome Data Viewer
Location:
1 H6; 1 96.78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191449682..191516367)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191717554..191784255)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene denticleless E3 ubiquitin protein ligase Neighboring gene STARR-positive B cell enhancer ABC_E803 Neighboring gene STARR-positive B cell enhancer ABC_E1579 Neighboring gene STARR-positive B cell enhancer mm9_chr1:193423192-193423493 Neighboring gene integrator complex subunit 7 Neighboring gene STARR-seq mESC enhancer starr_03434 Neighboring gene predicted gene, 39741 Neighboring gene predicted gene, 22446 Neighboring gene predicted gene, 26203 Neighboring gene predicted gene, 20203 Neighboring gene STARR-positive B cell enhancer ABC_E1580 Neighboring gene STARR-positive B cell enhancer ABC_E4409 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport. Sun H, et al. Cell Rep, 2023 Nov 28. PMID 37917582, Free PMC Article
  2. LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling. Xu Y, et al. J Biol Chem, 2022 Mar. PMID 35131264, Free PMC Article
  3. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase. Kawana H, et al. J Lipid Res, 2022 Oct. PMID 36049524, Free PMC Article
  4. Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion. Hiramine Y, et al. J Lipid Res, 2010 Jun. PMID 20018982, Free PMC Article
  5. LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles. Sato T, et al. J Biol Chem, 2023 Jul. PMID 37217003, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
    Title: LPGAT1 controls MEGDEL syndrome by coupling phosphatidylglycerol remodeling with mitochondrial transport.
  2. LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles.
    Title: LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles.
  3. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase.
    Title: Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase.
  4. LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling.
    Title: LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling.
  5. LPGAT1, a newly identified MGAT enzyme, plays a significant role in hepatic triacylglycerol synthesis and secretion in db/db mice.
    Title: Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0205, MGC18768

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidylethanolamine acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipid acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipid acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
acyl-CoA:lysophosphatidylglycerol acyltransferase 1
Names
2-acylglycerophosphocholine O-acyltransferase
acyl-CoA:monoacylglycerol acyltransferase LPGAT1
lysophospholipid acyltransferase 7
stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase
NP_001128301.1
NP_001408072.1
NP_001408073.1
NP_001408074.1
NP_001408075.1
NP_758470.1
XP_006497220.1
XP_036020142.1
XP_036020144.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134829.2 → NP_001128301.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_001128301.1

    Status: VALIDATED

    Source sequence(s)
    AC157810
    Consensus CDS
    CCDS48488.1
    UniProtKB/TrEMBL
    E9QL80, Q6A0A4
    Related
    ENSMUSP00000106480.2, ENSMUST00000110856.8
    Conserved Domains (2) summary
    cd07990
    Location:108 → 324
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:313 → 382
    Acyltransf_C; Acyltransferase C-terminus

  2. NM_001421143.1 → NP_001408072.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157810
    UniProtKB/TrEMBL
    E9QL80

  3. NM_001421144.1 → NP_001408073.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157810
    UniProtKB/Swiss-Prot
    Q91YX5

  4. NM_001421145.1 → NP_001408074.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157810
    UniProtKB/Swiss-Prot
    Q91YX5

  5. NM_001421146.1 → NP_001408075.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157810
    UniProtKB/Swiss-Prot
    Q91YX5

  6. NM_172266.4 → NP_758470.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_758470.1

    Status: VALIDATED

    Source sequence(s)
    AC157810
    Consensus CDS
    CCDS15622.1
    UniProtKB/Swiss-Prot
    Q91YX5
    UniProtKB/TrEMBL
    Q6A0A4
    Related
    ENSMUSP00000106479.2, ENSMUST00000110855.8
    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 329
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191449682..191516367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164249.1 → XP_036020142.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2

    Conserved Domains (2) summary
    cd07990
    Location:108 → 324
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:313 → 360
    Acyltransf_C; Acyltransferase C-terminus

  2. XM_036164251.1 → XP_036020144.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X4

    Conserved Domains (2) summary
    cd07990
    Location:69 → 285
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:274 → 321
    Acyltransf_C; Acyltransferase C-terminus

  3. XM_006497157.5 → XP_006497220.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X5

    UniProtKB/TrEMBL
    Q8R1E1
    Conserved Domains (2) summary
    cd07990
    Location:2 → 207
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:196 → 265
    Acyltransf_C; Acyltransferase C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YX5.1 GenPept UniProtKB/Swiss-Prot:Q91YX5

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