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Zfp239 zinc finger protein 239 [ Mus musculus (house mouse) ]

Gene ID: 22685, updated on 30-Apr-2024

Summary

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Official Symbol
Zfp239provided by MGI
Official Full Name
zinc finger protein 239provided by MGI
Primary source
MGI:MGI:1306812
See related
Ensembl:ENSMUSG00000042097 AllianceGenome:MGI:1306812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mok2; Mok-2; Znf239
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human ZNF239 (zinc finger protein 239). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 8.3), frontal lobe adult (RPKM 6.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp239 in Genome Data Viewer
Location:
6 F1; 6 55.62 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117838907..117849727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117862024..117872766)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 6, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117791080-117791189 Neighboring gene zinc finger protein 637 Neighboring gene STARR-seq mESC enhancer starr_17123 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850148-117850426 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:117850781-117850973 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene STARR-positive B cell enhancer ABC_E1069 Neighboring gene heterogeneous nuclear ribonucleoprotein F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The gene encoding the MOK-2 zinc-finger protein: characterization of its promoter and negative regulation by mouse Alu type-2 repetitive elements. Arranz V, et al. Gene, 1994 Nov 18. PMID 7959005
  2. A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells. Ernoult-Lange M, et al. Mol Cell Biol, 1990 Jan. PMID 2104662, Free PMC Article
  3. Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains. Arranz V, et al. Mol Cell Biol, 1997 Apr. PMID 9121460, Free PMC Article
  4. Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins. Ernoult-Lange M, et al. J Mol Evol, 1995 Dec. PMID 8587123
  5. Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19. Arranz V, et al. Mamm Genome, 1996 Jan. PMID 8903737

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 239
Names
Kruppel zinc finger protein 2
zinc finger protein MOK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001792.3 → NP_001001792.1  zinc finger protein 239

    See identical proteins and their annotated locations for NP_001001792.1

    Status: VALIDATED

    Source sequence(s)
    AC153918
    Consensus CDS
    CCDS20466.1
    UniProtKB/Swiss-Prot
    P24399, Q99J71
    Related
    ENSMUSP00000128270.2, ENSMUST00000172088.8
    Conserved Domains (3) summary
    COG5048
    Location:4 → 148
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:114 → 201
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001360938.2 → NP_001347867.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    Consensus CDS
    CCDS20466.1
    UniProtKB/Swiss-Prot
    P24399, Q99J71
    Conserved Domains (3) summary
    COG5048
    Location:4 → 148
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:114 → 201
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001410517.1 → NP_001397446.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    UniProtKB/Swiss-Prot
    P24399, Q99J71

  4. NM_001410518.1 → NP_001397447.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    UniProtKB/Swiss-Prot
    P24399, Q99J71

  5. NM_001410519.1 → NP_001397448.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    UniProtKB/Swiss-Prot
    P24399, Q99J71

  6. NM_001410521.1 → NP_001397450.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    UniProtKB/Swiss-Prot
    P24399, Q99J71

  7. NM_001410522.1 → NP_001397451.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    UniProtKB/Swiss-Prot
    P24399, Q99J71

  8. NM_001410523.1 → NP_001397452.1  zinc finger protein 239

    Status: VALIDATED

    Source sequence(s)
    AC153918
    UniProtKB/Swiss-Prot
    P24399, Q99J71

  9. NM_008616.4 → NP_032642.2  zinc finger protein 239

    See identical proteins and their annotated locations for NP_032642.2

    Status: VALIDATED

    Source sequence(s)
    AC153918
    Consensus CDS
    CCDS20466.1
    UniProtKB/Swiss-Prot
    P24399, Q99J71
    Related
    ENSMUSP00000078374.8, ENSMUST00000079405.15
    Conserved Domains (3) summary
    COG5048
    Location:4 → 148
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:114 → 201
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_177085.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153918

  2. NR_177086.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153918

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    117838907..117849727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255322.2 → XP_030111182.1  zinc finger protein 239 isoform X1

    UniProtKB/Swiss-Prot
    P24399, Q99J71
    Conserved Domains (3) summary
    COG5048
    Location:4 → 148
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:114 → 201
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030255323.2 → XP_030111183.1  zinc finger protein 239 isoform X1

    UniProtKB/Swiss-Prot
    P24399, Q99J71
    Conserved Domains (3) summary
    COG5048
    Location:4 → 148
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:114 → 201
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036166030.1 → XP_036021923.1  zinc finger protein 239 isoform X1

    UniProtKB/Swiss-Prot
    P24399, Q99J71
    Conserved Domains (3) summary
    COG5048
    Location:4 → 148
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:114 → 201
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:120 → 140
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24399.2 GenPept UniProtKB/Swiss-Prot:P24399

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