Trim26 tripartite motif-containing 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim26provided by MGI
Official Full Name: tripartite motif-containing 26provided by MGI
Primary source: MGI:MGI:1337056
See related: Ensembl:ENSMUSG00000024457 AllianceGenome:MGI:1337056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp173; Zfp1736
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of non-canonical NF-kappaB signal transduction; and protein K11-linked ubiquitination. Located in cytoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to human TRIM26 (tripartite motif containing 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 19.3), spleen adult (RPKM 16.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 19.16 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (37148016..37170290)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (36837123..36859398)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM26 deficiency enhancing liver regeneration through macrophage polarization and beta-catenin pathway activation.
Title: TRIM26 deficiency enhancing liver regeneration through macrophage polarization and β-catenin pathway activation.
TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.
Title: TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection.
Sustained exposure of cells to TGF-beta resulted in recovery from proliferative arrest in association with amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26 induction by TGF-beta.
Title: Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.
Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26-mediated IRF3 ubiquitination and degradation.
Title: TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI462198 (e-PCR)
- UniSTS:160645

Trim26 (e-PCR), detects polymorphism
- UniSTS:144824

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in suppression of viral release by host	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 26

Names: tripartite motif protein 26; tripartite motif protein TRIM26; zinc finger protein 173

NP_001020770.2

EC 2.3.2.27

NP_001273655.1

EC 2.3.2.27

NP_001273656.1

EC 2.3.2.27

XP_006524276.1

EC 2.3.2.27

XP_006524277.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025599.3 → NP_001020770.2 tripartite motif-containing protein 26

See identical proteins and their annotated locations for NP_001020770.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) has an alternate splice site in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.

Source sequence(s)

BC037110, BQ176978, CF168373

Consensus CDS

CCDS37613.1

UniProtKB/Swiss-Prot

B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3

UniProtKB/TrEMBL

Q3UFX3

Related

ENSMUSP00000060103.8, ENSMUST00000053434.15

Conserved Domains (3) summary

cd15826
Location:320 → 544

SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
NM_001286726.1 → NP_001273655.1 tripartite motif-containing protein 26

See identical proteins and their annotated locations for NP_001273655.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 3 and 4 encode the same protein.

Source sequence(s)

AK042252, BC037110, BQ176978, CF168373

Consensus CDS

CCDS37613.1

UniProtKB/Swiss-Prot

B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3

UniProtKB/TrEMBL

Q3UFX3

Conserved Domains (3) summary

cd15826
Location:320 → 544

SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
NM_001286727.1 → NP_001273656.1 tripartite motif-containing protein 26

See identical proteins and their annotated locations for NP_001273656.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate splice junction in the 5' UTR, compared to variant 3. Variants 1, 3 and 4 encode the same protein.

Source sequence(s)

AK148247, BC037110, BQ176978, CF168373

Consensus CDS

CCDS37613.1

UniProtKB/Swiss-Prot

B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3

UniProtKB/TrEMBL

Q3UFX3

Related

ENSMUSP00000114896.2, ENSMUST00000130367.8

Conserved Domains (3) summary

cd15826
Location:320 → 544

SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

37148016..37170290

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524214.4 → XP_006524277.1 tripartite motif-containing protein 26 isoform X2

See identical proteins and their annotated locations for XP_006524277.1

UniProtKB/TrEMBL

Q3UFX3

Conserved Domains (3) summary

cd15826
Location:314 → 538

SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins
XM_006524213.4 → XP_006524276.1 tripartite motif-containing protein 26 isoform X1

See identical proteins and their annotated locations for XP_006524276.1

UniProtKB/Swiss-Prot

B8JJ55, Q8C9E9, Q8JZT7, Q99PN2, Q99PN3

UniProtKB/TrEMBL

Q3UFX3

Conserved Domains (3) summary

cd15826
Location:320 → 544

SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_030698.4: Suppressed sequence

Description

NM_030698.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.