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Ifi207 interferon activated gene 207 [ Mus musculus (house mouse) ]

Gene ID: 226691, updated on 2-Nov-2024

Summary

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Official Symbol
Ifi207provided by MGI
Official Full Name
interferon activated gene 207provided by MGI
Primary source
MGI:MGI:2138302
See related
Ensembl:ENSMUSG00000073490 AllianceGenome:MGI:2138302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pyhinA; Pyhin-A
Summary
Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of innate immune response. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 13.2), subcutaneous fat pad adult (RPKM 6.7) and 17 other tissues See more
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Genomic context

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See Ifi207 in Genome Data Viewer
Location:
1 H3; 1 80.61 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173550993..173569394, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173723424..173741831, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pyrin and HIN domain family, member 1 pseudogene Neighboring gene predicted gene 7871 Neighboring gene interferon activated gene 204 Neighboring gene interferon activated gene 203, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:175731887-175732188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. Choubey D, et al. J Biol Chem, 1989 Oct 15. PMID 2477366
  2. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. Moran EA, et al. mBio, 2024 Jul 17. PMID 38860764, Free PMC Article
  3. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
  4. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.
    Title: IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC183622

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of AIM2 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC226691
Names
interferon-activatable protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204910.1 → NP_001191839.1  uncharacterized protein LOC226691

    Status: VALIDATED

    Source sequence(s)
    AC117682, AK054438, BE335648, BE634329, BX527645, CJ056316, CJ065456
    Consensus CDS
    CCDS56659.1
    UniProtKB/TrEMBL
    D3Z2E7, E9Q3L4
    Related
    ENSMUSP00000048129.8, ENSMUST00000042610.15
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; Pyrin: a protein-protein interaction domain
    pfam02760
    Location:788 → 954
    HIN; HIN-200/IF120x domain
    pfam06752
    Location:608 → 724
    E_Pc_C; Enhancer of Polycomb C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173550993..173569394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238800.4 → XP_011237102.1  uncharacterized protein LOC226691 isoform X6

    UniProtKB/TrEMBL
    D3Z2E7
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:574 → 766
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:785 → 951
    HIN; HIN-200/IF120x domain

  2. XM_011238799.4 → XP_011237101.1  uncharacterized protein LOC226691 isoform X5

    UniProtKB/TrEMBL
    D3Z2E7
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:574 → 813
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:799 → 965
    HIN; HIN-200/IF120x domain

  3. XM_036164142.1 → XP_036020035.1  uncharacterized protein LOC226691 isoform X4

    UniProtKB/TrEMBL
    D3Z2E7
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:574 → 827
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:813 → 979
    HIN; HIN-200/IF120x domain

  4. XM_011238798.4 → XP_011237100.1  uncharacterized protein LOC226691 isoform X2

    UniProtKB/TrEMBL
    D3Z2E7
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:572 → 853
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:839 → 1005
    HIN; HIN-200/IF120x domain

  5. XM_006496794.5 → XP_006496857.1  uncharacterized protein LOC226691 isoform X3

    UniProtKB/TrEMBL
    D3Z2E7
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:561 → 842
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:828 → 994
    HIN; HIN-200/IF120x domain

  6. XM_011238797.4 → XP_011237099.1  uncharacterized protein LOC226691 isoform X1

    UniProtKB/TrEMBL
    D3Z2E7
    Conserved Domains (3) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam05109
    Location:574 → 855
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam02760
    Location:841 → 1007
    HIN; HIN-200/IF120x domain
Nucleotide Protein Strain
Heading Accession and Version

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