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Rnf103 ring finger protein 103 [ Mus musculus (house mouse) ]

Gene ID: 22644, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf103provided by MGI
Official Full Name
ring finger protein 103provided by MGI
Primary source
MGI:MGI:109483
See related
Ensembl:ENSMUSG00000052656 AllianceGenome:MGI:109483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kf-1; Zfp103
Summary
This gene encodes a member of the RING finger family of E3 ubiquitin-protein ligases. These proteins catalyze the transfer of the ubiquitin protein from a ubiquitin E2 enzyme to a protein substrate. Homozygous knockout mice for this gene exhibit enhanced anxiety-like behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in colon adult (RPKM 26.1), duodenum adult (RPKM 20.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf103 in Genome Data Viewer
Location:
6 C1; 6 32.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71470828..71487864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71493844..71510880)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16262 Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene STARR-positive B cell enhancer ABC_E343 Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene STARR-positive B cell enhancer ABC_E8110 Neighboring gene charged multivesicular body protein 3 Neighboring gene STARR-seq mESC enhancer starr_16264 Neighboring gene lysine (K)-specific demethylase 3A Neighboring gene STARR-seq mESC enhancer starr_16265 Neighboring gene STARR-positive B cell enhancer ABC_E3659

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KF-1 ubiquitin ligase: anxiety suppressor model. Hashimoto-Gotoh T, et al. Cell Biochem Biophys, 2011 Jun. PMID 21455683
  2. KF-1 Ubiquitin Ligase: An Anxiety Suppressor. Hashimoto-Gotoh T, et al. Front Neurosci, 2009 May. PMID 19753093, Free PMC Article
  3. Mice lacking the kf-1 gene exhibit increased anxiety- but not despair-like behavior. Tsujimura A, et al. Front Behav Neurosci, 2008. PMID 18958194, Free PMC Article
  4. Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Yasojima K, et al. Biochem Biophys Res Commun, 1997 Feb 13. PMID 9070305
  5. Identification of a novel gene with RING-H2 finger motif induced after chronic antidepressant treatment in rat brain. Yamada M, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071867

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF103
Names
RING-type E3 ubiquitin transferase RNF103
zinc finger protein 103
NP_001295232.1
NP_001397436.1
NP_001397437.1
NP_033569.2
XP_036021921.1
XP_036021922.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308303.2 → NP_001295232.1  E3 ubiquitin-protein ligase RNF103 isoform 2

    See identical proteins and their annotated locations for NP_001295232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 3' terminal exon, resulting in a distinct 5' UTR and the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4 all encode the same isoform (2).
    Source sequence(s)
    AC154001
    UniProtKB/TrEMBL
    Q3TGP6
    Conserved Domains (1) summary
    cd16473
    Location:444 → 489
    RING-H2_RNF103; RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins

  2. NM_001410507.1 → NP_001397436.1  E3 ubiquitin-protein ligase RNF103 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC154001
    UniProtKB/TrEMBL
    Q3TGP6

  3. NM_001410508.1 → NP_001397437.1  E3 ubiquitin-protein ligase RNF103 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC154001
    UniProtKB/TrEMBL
    Q3TGP6

  4. NM_009543.4 → NP_033569.2  E3 ubiquitin-protein ligase RNF103 isoform 1

    See identical proteins and their annotated locations for NP_033569.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC154001
    Consensus CDS
    CCDS39508.1
    UniProtKB/Swiss-Prot
    B9EHC2, O08670, O08883, Q9R1W3
    Related
    ENSMUSP00000066324.5, ENSMUST00000064637.11
    Conserved Domains (1) summary
    cd00162
    Location:618 → 661
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71470828..71487864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166029.1 → XP_036021922.1  E3 ubiquitin-protein ligase RNF103 isoform X2

    UniProtKB/TrEMBL
    D3Z0Y5, Q3UYK9
    Related
    ENSMUSP00000109816.2, ENSMUST00000114178.8

  2. XM_036166028.1 → XP_036021921.1  E3 ubiquitin-protein ligase RNF103 isoform X1

    UniProtKB/TrEMBL
    Q3UYK9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1W3.2 GenPept UniProtKB/Swiss-Prot:Q9R1W3

Gene LinkOut

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