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Prlhr prolactin releasing hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 226278, updated on 2-Nov-2024

Summary

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Official Symbol
Prlhrprovided by MGI
Official Full Name
prolactin releasing hormone receptorprovided by MGI
Primary source
MGI:MGI:2135956
See related
Ensembl:ENSMUSG00000045052 AllianceGenome:MGI:2135956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gr3; Gm339; Gpr10; Prrpr
Summary
Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; feeding behavior; and hormone metabolic process. Is active in cilium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Prlhr in Genome Data Viewer
Location:
19 D3; 19 56.52 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60454079..60457907, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60465641..60468933, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:60386552-60386852 Neighboring gene predicted gene, 41882 Neighboring gene predicted gene, 34300 Neighboring gene CDK2 associated, cullin domain 1 Neighboring gene predicted gene, 41884 Neighboring gene STARR-seq mESC enhancer starr_46598 Neighboring gene STARR-positive B cell enhancer ABC_E3256 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60684594-60684894 Neighboring gene STARR-seq mESC enhancer starr_46599 Neighboring gene predicted gene, 46652

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis. Pražienková V, et al. Gene, 2021 Mar 30. PMID 33450349
  2. GPR10 deficiency in mice results in altered energy expenditure and obesity. Bjursell M, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17904108
  3. Prolactin-releasing Peptide mediates cholecystokinin-induced satiety in mice. Bechtold DA, et al. Endocrinology, 2006 Oct. PMID 16794001
  4. The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10. Laurent P, et al. Nat Neurosci, 2005 Dec. PMID 16299503
  5. A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Talbot F, et al. Nat Commun, 2023 Mar 15. PMID 36922513, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis.
    Title: GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis.
  2. Female mice deficient of the gene encoding GPR10 develop higher body weight and obesity due to lower energy expenditure.
    Title: GPR10 deficiency in mice results in altered energy expenditure and obesity.
  3. Altogether, our data identify the PrRP-GPR10 system as a new and potent negative modulator of the opioid system.
    Title: The prolactin-releasing peptide antagonizes the opioid system through its receptor GPR10.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolactin-releasing peptide receptor
Names
G-protein coupled receptor 10
PrRP receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201615.2 → NP_963909.2  prolactin-releasing peptide receptor

    See identical proteins and their annotated locations for NP_963909.2

    Status: VALIDATED

    Source sequence(s)
    AC167713
    Consensus CDS
    CCDS29940.1
    UniProtKB/Swiss-Prot
    E9QJU3, Q059H6, Q6VMN6
    Related
    ENSMUSP00000063114.3, ENSMUST00000051277.4
    Conserved Domains (1) summary
    cd15394
    Location:61 → 346
    7tmA_PrRP_R; prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    60454079..60457907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527057.4 → XP_006527120.1  prolactin-releasing peptide receptor isoform X1

    See identical proteins and their annotated locations for XP_006527120.1

    UniProtKB/Swiss-Prot
    E9QJU3, Q059H6, Q6VMN6
    Conserved Domains (1) summary
    cd15394
    Location:61 → 346
    7tmA_PrRP_R; prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VMN6.2 GenPept UniProtKB/Swiss-Prot:Q6VMN6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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