Siae sialic acid acetylesterase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Siaeprovided by MGI
Official Full Name: sialic acid acetylesteraseprovided by MGI
Primary source: MGI:MGI:104803
See related: Ensembl:ENSMUSG00000001942 AllianceGenome:MGI:104803
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LSE; Ysg2
Summary: Predicted to enable sialate O-acetylesterase activity. Predicted to be involved in carbohydrate metabolic process and regulation of immune system process. Located in lysosome. Is expressed in several structures, including abdominal fat pad; central nervous system; genitourinary system; immune system; and yolk sac. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human SIAE (sialic acid acetylesterase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 7.5), liver adult (RPKM 6.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.79 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (37525117..37559554)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (37613821..37648258)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sialate:O-acetyl esterase is a catalytic regulator of B cell signaling and plays an essential role in the maintenance of immunological tolerance in the B lineage.
Title: B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125865 (e-PCR)
- UniSTS:162601

Ysg2 (e-PCR), detects polymorphism
- UniSTS:256877

BB241090 (e-PCR)
- UniSTS:208360

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sialate 9-O-acetylesterase activity	IEA Inferred from Electronic Annotation more info
enables sialate O-acetylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sialate O-acetylesterase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune system process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sialate O-acetylesterase

Names: clone 165; sialic acid-specific 9-O-acetylesterase; yolk sac gene 2; yolk sac protein 2

NP_035864.2

EC 3.1.1.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.