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Morn4 MORN repeat containing 4 [ Mus musculus (house mouse) ]

Gene ID: 226123, updated on 2-Nov-2024

Summary

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Official Symbol
Morn4provided by MGI
Official Full Name
MORN repeat containing 4provided by MGI
Primary source
MGI:MGI:2449568
See related
Ensembl:ENSMUSG00000049670 AllianceGenome:MGI:2449568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in response to axon injury. Is active in stereocilium tip. Is expressed in gut; nervous system; and sensory organ. Orthologous to human MORN4 (MORN repeat containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 80.1), CNS E18 (RPKM 49.2) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Morn4 in Genome Data Viewer
Location:
19 C3; 19 35.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42063378..42074815, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42074939..42086376, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 2 Neighboring gene RIKEN cDNA 4933411K16 gene Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene STARR-seq mESC enhancer starr_46172 Neighboring gene STARR-positive B cell enhancer ABC_E781 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha Neighboring gene STARR-seq mESC enhancer starr_46173 Neighboring gene STARR-seq mESC enhancer starr_46176 Neighboring gene arginine vasopressin-induced 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MORN4 protects cardiomyocytes against ischemic injury via MFN2-mediated mitochondrial dynamics and mitophagy. Zhou J, et al. Free Radic Biol Med, 2023 Feb 20. PMID 36682578
  2. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. Bhattacharya MR, et al. J Neurosci, 2012 Apr 11. PMID 22496551, Free PMC Article
  3. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, et al. J Cell Biol, 2016 Jan 18. PMID 26754646, Free PMC Article
  4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MORN4 protects cardiomyocytes against ischemic injury via MFN2-mediated mitochondrial dynamics and mitophagy.
    Title: MORN4 protects cardiomyocytes against ischemic injury via MFN2-mediated mitochondrial dynamics and mitophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to axon injury IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in filopodium tip ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium tip ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in stereocilium tip EXP
Inferred from Experiment
more info
 PubMed 
located_in stereocilium tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MORN repeat-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198108.2 → NP_932776.1  MORN repeat-containing protein 4

    See identical proteins and their annotated locations for NP_932776.1

    Status: VALIDATED

    Source sequence(s)
    AC133503, AK159230, AU256607, BB871690, CV563048
    Consensus CDS
    CCDS37990.1
    UniProtKB/Swiss-Prot
    Q6PGF2
    Related
    ENSMUSP00000062887.9, ENSMUST00000051772.10
    Conserved Domains (1) summary
    PLN03185
    Location:6 → 143
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    42063378..42074815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250897.1 → XP_030106757.1  MORN repeat-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q6PGF2
    Conserved Domains (1) summary
    PLN03185
    Location:6 → 143
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGF2.1 GenPept UniProtKB/Swiss-Prot:Q6PGF2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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