U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc6a20b solute carrier family 6 (neurotransmitter transporter), member 20B [ Mus musculus (house mouse) ]

Gene ID: 22599, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Slc6a20bprovided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter), member 20Bprovided by MGI
Primary source
MGI:MGI:1336891
See related
Ensembl:ENSMUSG00000025243 AllianceGenome:MGI:1336891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XT3; Sit1; Xtrp3; Slc6a20
Summary
Predicted to enable L-proline transmembrane transporter activity and proline:sodium symporter activity. Predicted to be involved in L-proline import across plasma membrane; glycine import across plasma membrane; and sodium ion transmembrane transport. Located in apical plasma membrane and brush border membrane. Is expressed in blood vessel; brain; genitourinary system; and meninges. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 92.2), duodenum adult (RPKM 16.4) and 2 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc6a20b in Genome Data Viewer
Location:
9 F4; 9 74.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123422888..123461603, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123593823..123632538, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E717 Neighboring gene nuclear encoded tRNA arginine 2 (anticodon ACG) Neighboring gene SAC1 suppressor of actin mutations 1-like (yeast) Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 20A Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes. Kim J, et al. Front Mol Neurosci, 2022. PMID 35321029, Free PMC Article
  2. Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20). Bröer A, et al. Mol Membr Biol, 2009 Aug. PMID 19657969
  3. Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter. Kowalczuk S, et al. Biochem J, 2005 Mar 15. PMID 15689184, Free PMC Article
  4. Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus. Romeo E, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16174864
  5. Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. Takanaga H, et al. J Biol Chem, 2005 Mar 11. PMID 15632147

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using homology modeling we identified two highly conserved Na(+)-binding sites and a putative Cl(-)-binding site of SLC6A20.
    Title: Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20).
  2. Up-regulated in the kidneys of 3-day-old mice, accounting for the maturation of proline reabsorption in the mouse.
    Title: Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino.
  3. molecular cloning of two mouse homologues corresponding to the single human SLC6A20 gene: these have been named XT3 and XT3s1
    Title: Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-proline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables solute:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-proline import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proline import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
sodium- and chloride-dependent transporter XTRP3B
Names
IMINO-K
X transporter protein 3
solute carrier family 6 (neurotransmitter transporter), member 20
solute carrier family 6, member 20B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410461.1 → NP_001397390.1  sodium- and chloride-dependent transporter XTRP3B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132852, LXEJ02000930

  2. NM_001410462.1 → NP_001397391.1  sodium- and chloride-dependent transporter XTRP3B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132852, LXEJ02000930

  3. NM_011731.4 → NP_035861.2  sodium- and chloride-dependent transporter XTRP3B isoform 1

    See identical proteins and their annotated locations for NP_035861.2

    Status: VALIDATED

    Source sequence(s)
    AC132852, AK144038
    Consensus CDS
    CCDS23661.1
    UniProtKB/Swiss-Prot
    E9QNK3, O88575, Q3TP52, Q91WT6
    UniProtKB/TrEMBL
    A0A803YV45
    Related
    ENSMUSP00000026273.10, ENSMUST00000026273.11
    Conserved Domains (1) summary
    cl00456
    Location:45 → 620
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123422888..123461603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88575.3 GenPept UniProtKB/Swiss-Prot:O88575

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools