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Cyb561a3 cytochrome b561 family, member A3 [ Mus musculus (house mouse) ]

Gene ID: 225912, updated on 2-Nov-2024

Summary

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Official Symbol
Cyb561a3provided by MGI
Official Full Name
cytochrome b561 family, member A3provided by MGI
Primary source
MGI:MGI:2686925
See related
Ensembl:ENSMUSG00000034445 AllianceGenome:MGI:2686925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lcytb; Cybasc3; 2310004G04Rik
Summary
Enables transmembrane ascorbate ferrireductase activity. Involved in intracellular iron ion homeostasis. Located in late endosome membrane and lysosomal membrane. Is expressed in ganglia; jaw bone; and neural retina. Orthologous to human CYB561A3 (cytochrome b561 family member A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 58.0), lung adult (RPKM 24.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Cyb561a3 in Genome Data Viewer
Location:
19 A; 19 6.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10554521..10574196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10577157..10596832)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene triokinase, FMN cyclase Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes. Zhang DL, et al. Biochim Biophys Acta, 2006 Dec. PMID 16996694
  2. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. Su D, et al. FEBS J, 2006 Aug. PMID 16911521
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC86114, 2310004G04Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane ascorbate ferrireductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysosomal membrane ascorbate-dependent ferrireductase CYB561A3
Names
cytochrome b ascorbate-dependent protein 3
lysosomal cytochrome b
NP_001268993.1
NP_001268994.1
NP_001268996.1
NP_001349359.1
NP_001349360.1
NP_958739.1
XP_006527001.1
XP_006527002.1
XP_006527003.1
XP_017173636.1
XP_030106739.1
XP_030106742.1
XP_030106743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282064.1 → NP_001268993.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

    See identical proteins and their annotated locations for NP_001268993.1

    Status: VALIDATED

    Source sequence(s)
    AC125093, AK139533, AK168841, BY387699
    Consensus CDS
    CCDS29582.1
    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Related
    ENSMUSP00000157672.2, ENSMUST00000235271.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  2. NM_001282065.1 → NP_001268994.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2

    See identical proteins and their annotated locations for NP_001268994.1

    Status: VALIDATED

    Source sequence(s)
    AC125093, AK139533, AK160179, AK168841, BY387699
    Consensus CDS
    CCDS89344.1
    UniProtKB/Swiss-Prot
    Q6P1H1
    Related
    ENSMUSP00000157602.2, ENSMUST00000237641.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  3. NM_001282067.2 → NP_001268996.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

    See identical proteins and their annotated locations for NP_001268996.1

    Status: VALIDATED

    Source sequence(s)
    AK139533, AK168841, BY387699
    Consensus CDS
    CCDS29582.1
    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Related
    ENSMUSP00000157884.2, ENSMUST00000237581.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  4. NM_001362430.1 → NP_001349359.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    Consensus CDS
    CCDS29582.1
    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Related
    ENSMUSP00000130680.2, ENSMUST00000168445.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  5. NM_001362431.1 → NP_001349360.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125093
    Consensus CDS
    CCDS29582.1
    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  6. NM_201351.2 → NP_958739.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

    See identical proteins and their annotated locations for NP_958739.1

    Status: VALIDATED

    Source sequence(s)
    AC125093, AK139533, AK168841, BY387699
    Consensus CDS
    CCDS29582.1
    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Related
    ENSMUSP00000158186.2, ENSMUST00000237814.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10554521..10574196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526940.4 → XP_006527003.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X2

    See identical proteins and their annotated locations for XP_006527003.1

    UniProtKB/Swiss-Prot
    Q6P1H1
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  2. XM_030250883.2 → XP_030106743.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  3. XM_017318147.3 → XP_017173636.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

    Related
    ENSMUSP00000157892.2, ENSMUST00000236352.2
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  4. XM_006526938.5 → XP_006527001.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

    See identical proteins and their annotated locations for XP_006527001.1

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  5. XM_030250879.1 → XP_030106739.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  6. XM_006526939.5 → XP_006527002.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

    See identical proteins and their annotated locations for XP_006527002.1

    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

  7. XM_030250882.2 → XP_030106742.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

    UniProtKB/Swiss-Prot
    Q3TVE2, Q3V3G2, Q6P1H1
    Conserved Domains (1) summary
    cl23723
    Location:10 → 188
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1H1.1 GenPept UniProtKB/Swiss-Prot:Q6P1H1

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