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Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 [ Mus musculus (house mouse) ]

Gene ID: 225887, updated on 14-Nov-2024

Summary

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Official Symbol
Ndufs8provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S8provided by MGI
Primary source
MGI:MGI:2385079
See related
Ensembl:ENSMUSG00000059734 AllianceGenome:MGI:2385079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TYKY; CI-23kD
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; and response to oxidative stress. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including early conceptus and oocyte. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 181.5), heart adult (RPKM 175.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ndufs8 in Genome Data Viewer
Location:
19 A; 19 3.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3958863..3962774, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3908863..3912774, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:3851584-3851885 Neighboring gene STARR-seq mESC enhancer starr_45333 Neighboring gene choline kinase alpha Neighboring gene STARR-seq mESC enhancer starr_45334 Neighboring gene T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 Neighboring gene STARR-positive B cell enhancer ABC_E9987 Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene predicted gene, 42059 Neighboring gene STARR-positive B cell enhancer ABC_E7624 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene STARR-seq mESC enhancer starr_45335

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
  2. The requirement of the mitochondrial protein NDUFS8 for angiogenesis. Xiong QW, et al. Cell Death Dis, 2024 Apr 9. PMID 38594244, Free PMC Article
  3. Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans. Schibler L, et al. Genome Res, 1998 Sep. PMID 9750190
  4. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  5. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The requirement of the mitochondrial protein NDUFS8 for angiogenesis.
    Title: The requirement of the mitochondrial protein NDUFS8 for angiogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC37950, MGC101957

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 8
NADH-ubiquinone oxidoreductase 23 kDa subunit
complex I-23kD
NP_001258372.1
NP_001258373.1
NP_659119.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271443.1 → NP_001258372.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

    See identical proteins and their annotated locations for NP_001258372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK135069, AK164901, BP775598
    Consensus CDS
    CCDS29402.1
    UniProtKB/Swiss-Prot
    Q8K3J1
    UniProtKB/TrEMBL
    Q3UY05, Q5M9P5, Q8VC72
    Related
    ENSMUSP00000158327.2, ENSMUST00000237341.2
    Conserved Domains (1) summary
    PRK05888
    Location:56 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI

  2. NM_001271444.1 → NP_001258373.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

    See identical proteins and their annotated locations for NP_001258373.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK135069, AK149674, BP775598
    Consensus CDS
    CCDS29402.1
    UniProtKB/Swiss-Prot
    Q8K3J1
    UniProtKB/TrEMBL
    Q3UY05, Q5M9P5, Q8VC72
    Related
    ENSMUSP00000158029.2, ENSMUST00000235847.2
    Conserved Domains (1) summary
    PRK05888
    Location:56 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI

  3. NM_144870.5 → NP_659119.2  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

    See identical proteins and their annotated locations for NP_659119.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK135069, AK153182, BP775598
    Consensus CDS
    CCDS29402.1
    UniProtKB/Swiss-Prot
    Q8K3J1
    UniProtKB/TrEMBL
    Q3UY05, Q5M9P5, Q8VC72
    Related
    ENSMUSP00000074600.7, ENSMUST00000075092.8
    Conserved Domains (1) summary
    PRK05888
    Location:56 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3958863..3962774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3J1.1 GenPept UniProtKB/Swiss-Prot:Q8K3J1

Gene LinkOut

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