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Ark2c arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C [ Mus musculus (house mouse) ]

Gene ID: 225743, updated on 2-Nov-2024

Summary

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Official Symbol
Ark2cprovided by MGI
Official Full Name
arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2Cprovided by MGI
Primary source
MGI:MGI:2444521
See related
Ensembl:ENSMUSG00000025427 AllianceGenome:MGI:2444521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akd2; Gm96; Rnf165; 2900024M11Rik; G630064H08Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including forelimb morphogenesis; nervous system development; and positive regulation of BMP signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human ARK2C (arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 11.0), CNS E14 (RPKM 9.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Ark2c in Genome Data Viewer
Location:
18 E3; 18 52.28 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77543806..77652832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77456110..77565136, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45117 Neighboring gene lipoxygenase homology domains 1 Neighboring gene USP6 N-terminal like pseudogene Neighboring gene STARR-seq mESC enhancer starr_45121 Neighboring gene predicted gene, 41784 Neighboring gene arkadia (RNF111) N-terminal like PKA signaling regulator 2N Neighboring gene predicted gene, 26014

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. Kelly CE, et al. PLoS Biol, 2013. PMID 23610558, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forelimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within innervation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within limb development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle structure development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARK2C
Names
E3 ubiquitin-protein ligase RNF165
arkadia 2
arkadia-like protein 2C
ring finger protein 165
NP_001157976.1
XP_036017022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164504.1 → NP_001157976.1  E3 ubiquitin-protein ligase ARK2C

    See identical proteins and their annotated locations for NP_001157976.1

    Status: VALIDATED

    Source sequence(s)
    AC102135, BB619563, BC066016, BY256046, BY279218, BY727947, CF745657
    Consensus CDS
    CCDS50327.1
    UniProtKB/Swiss-Prot
    E9QAU8, Q3UZA7
    Related
    ENSMUSP00000026494.7, ENSMUST00000026494.14
    Conserved Domains (2) summary
    pfam07573
    Location:30 → 84
    AreA_N; Nitrogen regulatory protein AreA N terminus
    pfam13639
    Location:295 → 336
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77543806..77652832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161129.1 → XP_036017022.1  E3 ubiquitin-protein ligase ARK2C isoform X1

    Conserved Domains (1) summary
    cd16474
    Location:226 → 271
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9QAU8.1 GenPept UniProtKB/Swiss-Prot:E9QAU8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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