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Flywch1 FLYWCH-type zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 224613, updated on 2-Nov-2024

Summary

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Official Symbol
Flywch1provided by MGI
Official Full Name
FLYWCH-type zinc finger 1provided by MGI
Primary source
MGI:MGI:2442638
See related
Ensembl:ENSMUSG00000040097 AllianceGenome:MGI:2442638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1552; E030034P13Rik
Summary
Predicted to enable transcription coactivator binding activity and transcription corepressor activity. Predicted to be involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nuclear body; and pericentric heterochromatin. Predicted to be part of transcription regulator complex. Is expressed in several structures, including adrenal gland; aorta; genitourinary system; nervous system; and neural retina. Orthologous to human FLYWCH1 (FLYWCH-type zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 34.9), testis adult (RPKM 26.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Flywch1 in Genome Data Viewer
Location:
17 A3.3; 17 12.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23971767..23993504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23752795..23774530, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene progestin and adipoQ receptor family member IV Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene kringle containing transmembrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4197 Neighboring gene FLYWCH family member 2 Neighboring gene predicted gene, 52285 Neighboring gene serine/arginine repetitive matrix 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FLYWCH-type zinc finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357993.1 → NP_001344922.1  FLYWCH-type zinc finger-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122821, AI849618
    UniProtKB/TrEMBL
    A0A2I3BRL2
    Conserved Domains (3) summary
    pfam04500
    Location:235 → 293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1 → 83
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294 → 351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

  2. NM_001357994.1 → NP_001344923.1  FLYWCH-type zinc finger-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122821, AI849618
    UniProtKB/TrEMBL
    A0A2I3BRL2
    Related
    ENSMUSP00000154618.2, ENSMUST00000227120.2
    Conserved Domains (3) summary
    pfam04500
    Location:235 → 293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1 → 83
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294 → 351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

  3. NM_153791.2 → NP_722486.2  FLYWCH-type zinc finger-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_722486.2

    Status: VALIDATED

    Source sequence(s)
    AK168389, BY128897, CA321280, CD553578
    Consensus CDS
    CCDS28463.1
    UniProtKB/Swiss-Prot
    E9QKQ2, Q3TH83, Q6ZPN0, Q8C792, Q8CI03
    UniProtKB/TrEMBL
    A0A2I3BRL2
    Related
    ENSMUSP00000083505.6, ENSMUST00000086325.13
    Conserved Domains (3) summary
    pfam04500
    Location:235 → 293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1 → 83
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294 → 401
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23971767..23993504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524082.5 → XP_006524145.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006524145.1

    UniProtKB/TrEMBL
    A0A2I3BRL2
    Conserved Domains (3) summary
    pfam04500
    Location:235 → 293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1 → 83
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294 → 351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1

  2. XM_006524083.5 → XP_006524146.1  FLYWCH-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006524146.1

    UniProtKB/TrEMBL
    A0A2I3BRL2
    Conserved Domains (3) summary
    pfam04500
    Location:235 → 293
    FLYWCH; FLYWCH zinc finger domain
    pfam15423
    Location:1 → 83
    FLYWCH_N; FLYWCH-type zinc finger-containing protein
    pfam16662
    Location:294 → 351
    FLYWCH_u; FLYWCH-type zinc finger-containing protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI03.2 GenPept UniProtKB/Swiss-Prot:Q8CI03

Gene LinkOut

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