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Adcy5 adenylate cyclase 5 [ Mus musculus (house mouse) ]

Gene ID: 224129, updated on 29-Oct-2024

Summary

Official Symbol
Adcy5provided by MGI
Official Full Name
adenylate cyclase 5provided by MGI
Primary source
MGI:MGI:99673
See related
Ensembl:ENSMUSG00000022840 AllianceGenome:MGI:99673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ac5
Summary
Enables adenylate cyclase activity; adenylate cyclase binding activity; and scaffold protein binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; locomotory behavior; and neuromuscular process controlling balance. Located in cilium and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Parkinson's disease. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 31.9), ovary adult (RPKM 30.5) and 23 other tissues See more
Orthologs
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Genomic context

See Adcy5 in Genome Data Viewer
Location:
16 B3; 16 24.71 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (34974933..35126108)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35154494..35305743)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40730 Neighboring gene STARR-seq mESC enhancer starr_40731 Neighboring gene STARR-positive B cell enhancer ABC_E1922 Neighboring gene predicted gene, 21691 Neighboring gene predicted gene, 53952 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene STARR-seq mESC enhancer starr_40734 Neighboring gene STARR-seq mESC enhancer starr_40735 Neighboring gene predicted gene, 46550 Neighboring gene predicted gene, 25179 Neighboring gene STARR-seq mESC enhancer starr_40736 Neighboring gene STARR-seq mESC enhancer starr_40737 Neighboring gene SEC22 homolog A, vesicle trafficking protein Neighboring gene predicted gene, 25079

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cAMP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenylate cyclase type 5
Names
ATP pyrophosphate-lyase 5
adenylate cyclase type V
adenylyl cyclase 5
NP_001012783.3
NP_001403984.1
NP_001403985.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012765.6NP_001012783.3  adenylate cyclase type 5 isoform 1

    See identical proteins and their annotated locations for NP_001012783.3

    Status: VALIDATED

    Source sequence(s)
    AC171205
    Consensus CDS
    CCDS37322.1
    UniProtKB/Swiss-Prot
    P84309, Q3TU67, Q3UH09, Q5BL06
    Related
    ENSMUSP00000110563.2, ENSMUST00000114913.3
    Conserved Domains (4) summary
    smart00044
    Location:425620
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:10631257
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:669761
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:1459
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. NM_001417055.1NP_001403984.1  adenylate cyclase type 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC171205
  3. NM_001417056.1NP_001403985.1  adenylate cyclase type 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC171205

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    34974933..35126108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)