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Krt73 keratin 73 [ Mus musculus (house mouse) ]

Gene ID: 223915, updated on 2-Nov-2024

Summary

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Official Symbol
Krt73provided by MGI
Official Full Name
keratin 73provided by MGI
Primary source
MGI:MGI:3607712
See related
Ensembl:ENSMUSG00000063661 AllianceGenome:MGI:3607712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K73; Kb36; CK-73
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Is expressed in external naris and vibrissa. Orthologous to human KRT73 (keratin 73). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Krt73 in Genome Data Viewer
Location:
15 F2; 15 57.03 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101701739..101710795, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101793304..101802360, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 74 Neighboring gene STARR-seq mESC enhancer starr_39803 Neighboring gene STARR-seq mESC enhancer starr_39804 Neighboring gene keratin 72 Neighboring gene keratin 2 Neighboring gene predicted gene, 35972

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Wu X, et al. Genes Dev, 2006 Mar 1. PMID 16510873, Free PMC Article
  2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
  3. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
  4. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type II cytoskeletal 73
Names
cytokeratin-73
type II inner root sheath-specific keratin-K6irs3
type II keratin Kb36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212485.3 → NP_997650.1  keratin, type II cytoskeletal 73

    See identical proteins and their annotated locations for NP_997650.1

    Status: VALIDATED

    Source sequence(s)
    AC104862
    Consensus CDS
    CCDS27864.1
    UniProtKB/Swiss-Prot
    Q6NXH9
    Related
    ENSMUSP00000065349.7, ENSMUST00000063292.8
    Conserved Domains (4) summary
    pfam00038
    Location:130 → 443
    Filament; Intermediate filament protein
    pfam16208
    Location:15 → 127
    Keratin_2_head; Keratin type II head
    cl19950
    Location:118 → 249
    Sec3_C; Exocyst complex component Sec3
    cl23720
    Location:356 → 412
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101701739..101710795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXH9.1 GenPept UniProtKB/Swiss-Prot:Q6NXH9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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