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Dbx2 developing brain homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 223843, updated on 2-Nov-2024

Summary

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Official Symbol
Dbx2provided by MGI
Official Full Name
developing brain homeobox 2provided by MGI
Primary source
MGI:MGI:107445
See related
Ensembl:ENSMUSG00000045608 AllianceGenome:MGI:107445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1229; 9630005K15; 9430056A22Rik
Summary
Acts upstream of or within several processes, including G2/M transition of mitotic cell cycle; epidermal growth factor receptor signaling pathway; and neural precursor cell proliferation. Is expressed in several structures, including central nervous system; limb; limb bud; sensory organ; and tooth mesenchyme. Orthologous to human DBX2 (developing brain homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 5.6), frontal lobe adult (RPKM 5.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Dbx2 in Genome Data Viewer
Location:
15 E3; 15 50.47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (95521444..95552838, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (95623563..95654771, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31551 Neighboring gene predicted gene, 24668 Neighboring gene VISTA enhancer mm1571 Neighboring gene predicted gene, 31690 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:95556425-95556608 Neighboring gene actin related protein 2/3 complex, subunit 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_39569 Neighboring gene predicted gene 6961

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors. Giuliani A, et al. Stem Cell Rev Rep, 2023 Nov. PMID 37605090, Free PMC Article
  2. Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline. Lupo G, et al. Aging Cell, 2018 Jun. PMID 29504228, Free PMC Article
  3. Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse. Shoji H, et al. Mech Dev, 1996 May. PMID 8798145
  4. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Pierani A, et al. Cell, 1999 Jun 25. PMID 10399918
  5. A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Beccari L, et al. Genes Dev, 2016 May 15. PMID 27198226, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors.
    Title: Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors.
  2. Results provide new insights into the molecular programmes that are affected during mouse NSPC aging, and uncover a new functional role for Dbx2 in promoting age-related neurogenic decline.
    Title: Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neural precursor cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
homeobox protein DBX2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207533.2 → NP_997416.2  homeobox protein DBX2

    See identical proteins and their annotated locations for NP_997416.2

    Status: VALIDATED

    Source sequence(s)
    AK035803, CX214447, CX214957
    Consensus CDS
    CCDS37183.1
    UniProtKB/TrEMBL
    F8VQH7
    Related
    ENSMUSP00000060424.7, ENSMUST00000054244.7
    Conserved Domains (2) summary
    COG5576
    Location:217 → 334
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:229 → 282
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    95521444..95552838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159373.1 → XP_036015266.1  homeobox protein DBX2 isoform X1

    Conserved Domains (2) summary
    COG5576
    Location:185 → 302
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam00046
    Location:197 → 251
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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