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Otulinl OTU deubiquitinase with linear linkage specificity like [ Mus musculus (house mouse) ]

Gene ID: 223433, updated on 2-Nov-2024

Summary

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Official Symbol
Otulinlprovided by MGI
Official Full Name
OTU deubiquitinase with linear linkage specificity likeprovided by MGI
Primary source
MGI:MGI:2687281
See related
Ensembl:ENSMUSG00000056069 AllianceGenome:MGI:2687281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam105a; 9830126M18
Summary
Predicted to be located in cytoplasmic side of endoplasmic reticulum membrane. Predicted to colocalize with nuclear envelope. Is expressed in embryo mesenchyme. Orthologous to human OTULINL (OTU deubiquitinase with linear linkage specificity like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 7.1), spleen adult (RPKM 5.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Otulinl in Genome Data Viewer
Location:
15 B1; 15 10.35 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (27655154..27681630, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (27655070..27681603, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:27560352-27560653 Neighboring gene OTU deubiquitinase with linear linkage specificity Neighboring gene predicted gene, 46506 Neighboring gene STARR-seq mESC enhancer starr_38229 Neighboring gene triple functional domain (PTPRF interacting) Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:27725815-27725968 Neighboring gene STARR-positive B cell enhancer ABC_E11588 Neighboring gene STARR-seq mESC enhancer starr_38230 Neighboring gene STARR-seq mESC enhancer starr_38231 Neighboring gene STARR-seq mESC enhancer starr_38233 Neighboring gene STARR-positive B cell enhancer ABC_E5471 Neighboring gene STARR-seq mESC enhancer starr_38236 Neighboring gene STARR-seq mESC enhancer starr_38238 Neighboring gene STARR-seq mESC enhancer starr_38239 Neighboring gene STARR-seq mESC enhancer starr_38240 Neighboring gene STARR-seq mESC enhancer starr_38241 Neighboring gene predicted gene, 29975 Neighboring gene predicted gene, 19883

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC59004

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
NOT enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables ubiquitin-like protein peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
NOT involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
colocalizes_with nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
inactive ubiquitin thioesterase OTULINL
Names
family with sequence similarity 105, member A
inactive ubiquitin thioesterase FAM105A
protein FAM105A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242423.2 → NP_001229352.1  inactive ubiquitin thioesterase OTULINL isoform 1

    See identical proteins and their annotated locations for NP_001229352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC158955
    Consensus CDS
    CCDS88743.1
    UniProtKB/Swiss-Prot
    Q3TVP5, Q3U8Q4, Q80WP7
    Related
    ENSMUSP00000154664.2, ENSMUST00000226145.2
    Conserved Domains (1) summary
    pfam16218
    Location:86 → 352
    Peptidase_C101; Peptidase family C101

  2. NM_001242424.2 → NP_001229353.1  inactive ubiquitin thioesterase OTULINL isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform (1).
    Source sequence(s)
    AC158955
    Consensus CDS
    CCDS88744.1
    UniProtKB/TrEMBL
    A0A2I3BPS6
    Related
    ENSMUSP00000153902.2, ENSMUST00000226170.2
    Conserved Domains (1) summary
    pfam16218
    Location:86 → 296
    Peptidase_C101; Peptidase family C101

  3. NM_001416118.1 → NP_001403047.1  inactive ubiquitin thioesterase OTULINL isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158955

  4. NM_001416119.1 → NP_001403048.1  inactive ubiquitin thioesterase OTULINL isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158955

  5. NM_198301.3 → NP_938043.1  inactive ubiquitin thioesterase OTULINL isoform 3

    See identical proteins and their annotated locations for NP_938043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC158955
    Consensus CDS
    CCDS27403.1
    UniProtKB/Swiss-Prot
    Q3TVP5
    Related
    ENSMUSP00000098305.4, ENSMUST00000100739.5
    Conserved Domains (1) summary
    pfam16218
    Location:86 → 302
    Peptidase_C101; Peptidase family C101

RNA

  1. NR_183254.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158955

  2. NR_183255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158955

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    27655154..27681630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TVP5.1 GenPept UniProtKB/Swiss-Prot:Q3TVP5

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