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Ggact gamma-glutamylamine cyclotransferase [ Mus musculus (house mouse) ]

Gene ID: 223267, updated on 2-Nov-2024

Summary

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Official Symbol
Ggactprovided by MGI
Official Full Name
gamma-glutamylamine cyclotransferaseprovided by MGI
Primary source
MGI:MGI:2385008
See related
Ensembl:ENSMUSG00000041625 AllianceGenome:MGI:2385008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A2ld1
Summary
Predicted to enable gamma-glutamylaminecyclotransferase activity. Predicted to be involved in cellular modified amino acid catabolic process. Predicted to be active in cytosol. Orthologous to human GGACT (gamma-glutamylamine cyclotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 25.9), liver adult (RPKM 22.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ggact in Genome Data Viewer
Location:
14 E5; 14 66.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (123128272..123151173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122890860..122913413, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene propionyl-Coenzyme A carboxylase, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E10845 Neighboring gene predicted gene, 46487 Neighboring gene STARR-seq mESC enhancer starr_37780 Neighboring gene STARR-seq mESC enhancer starr_37781 Neighboring gene STARR-seq mESC enhancer starr_37782 Neighboring gene STARR-seq mESC enhancer starr_37783 Neighboring gene STARR-positive B cell enhancer mm9_chr14:123229731-123230031 Neighboring gene predicted gene, 53848 Neighboring gene RIKEN cDNA 4930594M22 gene Neighboring gene predicted gene, 46488 Neighboring gene STARR-seq mESC enhancer starr_37784 Neighboring gene transmembrane and tetratricopeptide repeat containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E8582 Neighboring gene predicted gene, 57613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Clone Names

  • MGC7867

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-glutamylaminecyclotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables gamma-glutamylaminecyclotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular modified amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular modified amino acid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-glutamylaminecyclotransferase
Names
AIG2-like domain 1
AIG2-like domain-containing protein 1
NP_001412730.1
NP_001412731.1
NP_001412732.1
NP_001412736.1
NP_001412737.1
NP_001412738.1
NP_001412739.1
NP_001412740.1
NP_663441.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425801.1 → NP_001412730.1  gamma-glutamylaminecyclotransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154499

  2. NM_001425802.1 → NP_001412731.1  gamma-glutamylaminecyclotransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154499

  3. NM_001425803.1 → NP_001412732.1  gamma-glutamylaminecyclotransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154499

  4. NM_001425807.1 → NP_001412736.1  gamma-glutamylaminecyclotransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154499
    UniProtKB/Swiss-Prot
    Q66JP0, Q923B0

  5. NM_001425808.1 → NP_001412737.1  gamma-glutamylaminecyclotransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154499
    UniProtKB/Swiss-Prot
    Q66JP0, Q923B0

  6. NM_001425809.1 → NP_001412738.1  gamma-glutamylaminecyclotransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154499
    UniProtKB/Swiss-Prot
    Q66JP0, Q923B0

  7. NM_001425810.1 → NP_001412739.1  gamma-glutamylaminecyclotransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154499
    UniProtKB/Swiss-Prot
    Q66JP0, Q923B0

  8. NM_001425811.1 → NP_001412740.1  gamma-glutamylaminecyclotransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154499
    UniProtKB/Swiss-Prot
    Q66JP0, Q923B0
    Related
    ENSMUSP00000124954.2, ENSMUST00000160401.8

  9. NM_145466.3 → NP_663441.1  gamma-glutamylaminecyclotransferase isoform 3

    See identical proteins and their annotated locations for NP_663441.1

    Status: VALIDATED

    Source sequence(s)
    AC154499
    Consensus CDS
    CCDS27351.1
    UniProtKB/Swiss-Prot
    Q66JP0, Q923B0
    UniProtKB/TrEMBL
    E0CX39
    Related
    ENSMUSP00000037278.6, ENSMUST00000038075.12
    Conserved Domains (1) summary
    pfam06094
    Location:4 → 134
    GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

RNA

  1. NR_189593.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154499
    Related
    ENSMUST00000161322.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    123128272..123151173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923B0.1 GenPept UniProtKB/Swiss-Prot:Q923B0

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