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RNF182 ring finger protein 182 [ Homo sapiens (human) ]

Gene ID: 221687, updated on 2-Nov-2024

Summary

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Official Symbol
RNF182provided by HGNC
Official Full Name
ring finger protein 182provided by HGNC
Primary source
HGNC:HGNC:28522
See related
Ensembl:ENSG00000180537 AllianceGenome:HGNC:28522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 4.5), bone marrow (RPKM 2.7) and 7 other tissues See more
Orthologs
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Genomic context

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See RNF182 in Genome Data Viewer
Location:
6p23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13924446..13980310)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13796680..13852762)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13924677..13980541)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901264 Neighboring gene Sharpr-MPRA regulatory region 2979 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:13755870-13756079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24039 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:13769328-13769828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13787884-13788716 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:13789385-13789553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16939 Neighboring gene uncharacterized LOC107986571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24040 Neighboring gene mitochondrial calcium uniporter regulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13872467-13873049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16941 Neighboring gene CRISPRi-validated cis-regulatory element chr6.697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:13924078-13924578 Neighboring gene NANOG hESC enhancer GRCh37_chr6:13944174-13944689 Neighboring gene mitochondrial ribosomal protein L35 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr6.702 Neighboring gene CRISPRi-validated cis-regulatory element chr6.703 Neighboring gene CRISPRi-validated cis-regulatory element chr6.704 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:14001334-14002533 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:14035147-14036346 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:14069795-14069896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24042 Neighboring gene NANOG hESC enhancer GRCh37_chr6:14088959-14089460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24043 Neighboring gene CRISPRi-FlowFISH-validated CD83 regulatory element GRCh37_chr6:14095567-14096067 Neighboring gene uncharacterized LOC105374939 Neighboring gene CRISPRi-validated cis-regulatory element chr6.709 Neighboring gene uncharacterized LOC124901265

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation. Cao Y, et al. FEBS Lett, 2019 Nov. PMID 31432514
  2. Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia-reperfusion injury. Wang JH, et al. J Cell Biochem, 2019 May. PMID 30450663
  3. RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma. Zeng X, et al. Immun Inflamm Dis, 2023 May. PMID 37249301, Free PMC Article
  4. PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma. Liu Y, et al. Oncogene, 2022 Jul. PMID 35688944
  5. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. Okamoto T, et al. Int J Mol Sci, 2020 May 30. PMID 32486221, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma.
    Title: RNF182 induces p65 ubiquitination to affect PDL1 transcription and suppress immune evasion in lung adenocarcinoma.
  2. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
    Title: The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
  3. E3 ubiquitin ligase RNF182 is highly expressed in macrophages and is specifically upregulated by Toll-like receptors (TLR) stimuli (TLR4, TLR3 and TLR9 agonists). Knockdown of RNF182 selectively amplifies TLR signaling by promoting the production of proinflammatory cytokines but not type I interferons in macrophages.
    Title: The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40772, MGC33993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF182
Names
RING-type E3 ubiquitin transferase RNF182
NP_001158504.1
NP_001158505.1
NP_001158506.1
NP_689950.1
XP_016865939.1
XP_047274326.1
XP_047274327.1
XP_054210605.1
XP_054210606.1
XP_054210607.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165032.2 → NP_001158504.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_001158504.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL138718, AW731636, BC030666, BC050030, DA803766, DB094450
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3
    Related
    ENSP00000442021.1, ENST00000544682.5
    Conserved Domains (1) summary
    cd16555
    Location:19 → 69
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

  2. NM_001165033.2 → NP_001158505.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_001158505.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK090576, AL138718, AW731636, BC030666, BC050030, DB176198
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3
    Related
    ENSP00000441271.1, ENST00000537388.1
    Conserved Domains (1) summary
    cd16555
    Location:19 → 69
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

  3. NM_001165034.2 → NP_001158506.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_001158506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AL138718, AW731636, BC030666, BC050030, DA123125
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3
    Related
    ENSP00000443228.1, ENST00000537663.5
    Conserved Domains (1) summary
    cd16555
    Location:19 → 69
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

  4. NM_152737.4 → NP_689950.1  E3 ubiquitin-protein ligase RNF182

    See identical proteins and their annotated locations for NP_689950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK315528, AL138718, AW731636, BC030666, BC050030
    Consensus CDS
    CCDS4531.1
    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3
    Related
    ENSP00000420465.1, ENST00000488300.6
    Conserved Domains (1) summary
    cd16555
    Location:19 → 69
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    13924446..13980310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010450.3 → XP_016865939.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3
    Conserved Domains (1) summary
    cd16555
    Location:19 → 69
    RING-HC_RNF182; RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins

  2. XM_047418370.1 → XP_047274326.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3

  3. XM_047418371.1 → XP_047274327.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    13796680..13852762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354632.1 → XP_054210607.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3

  2. XM_054354630.1 → XP_054210605.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3

  3. XM_054354631.1 → XP_054210606.1  E3 ubiquitin-protein ligase RNF182 isoform X1

    UniProtKB/Swiss-Prot
    B2RDG2, Q8N6D2, Q8NBG3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6D2.1 GenPept UniProtKB/Swiss-Prot:Q8N6D2

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