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Tuba4a tubulin, alpha 4A [ Mus musculus (house mouse) ]

Gene ID: 22145, updated on 2-Nov-2024

Summary

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Official Symbol
Tuba4aprovided by MGI
Official Full Name
tubulin, alpha 4Aprovided by MGI
Primary source
MGI:MGI:1095410
See related
Ensembl:ENSMUSG00000026202 AllianceGenome:MGI:1095410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M[a]4; Tuba4
Summary
Enables enzyme binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in early embryo; lung; nervous system; and retina layer. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 120.6), liver E14.5 (RPKM 60.0) and 20 other tissues See more
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Genomic context

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See Tuba4a in Genome Data Viewer
Location:
1 C4; 1 38.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75190867..75197905, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75214972..75221261, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 9A Neighboring gene STARR-positive B cell enhancer ABC_E321 Neighboring gene ankyrin repeat and zinc finger domain containing 1 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene STARR-positive B cell enhancer ABC_E3282 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene STARR-seq mESC enhancer starr_01353 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene protein tyrosine phosphatase receptor type N

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An essential role for α4A-tubulin in platelet biogenesis. Strassel C, et al. Life Sci Alliance, 2019 Feb. PMID 30760556, Free PMC Article
  2. Loss of α4A- and β1-tubulins leads to severe platelet spherocytosis and strongly impairs hemostasis in mice. Kimmerlin Q, et al. Blood, 2022 Nov 24. PMID 36026602
  3. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice. Hausrat TJ, et al. Nat Commun, 2022 Jul 20. PMID 35858909, Free PMC Article
  4. Expression patterns of Sema3A in developing amniote limbs: With reference to the diversification of peripheral nerve innervation. Noguchi K, et al. Dev Growth Differ, 2017 May. PMID 28555754
  5. Codon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in mice. Leca I, et al. Sci Rep, 2023 Jan 21. PMID 36681692, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tubulin alpha-4A chain
Names
alpha-tubulin isotype M-alpha-4
tubulin alpha-4 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313723.2 → NP_001300652.1  tubulin alpha-4A chain isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Conserved Domains (1) summary
    cl25946
    Location:1 → 246
    Tubulin; Tubulin/FtsZ family, GTPase domain

  2. NM_001313724.2 → NP_001300653.1  tubulin alpha-4A chain isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166150
    UniProtKB/TrEMBL
    Q99KA2
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 295
    PTZ00335; tubulin alpha chain; Provisional

  3. NM_001420874.1 → NP_001407803.1  tubulin alpha-4A chain isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166150

  4. NM_001420875.1 → NP_001407804.1  tubulin alpha-4A chain isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Related
    ENSMUSP00000078429.8, ENSMUST00000079464.13

  5. NM_001420876.1 → NP_001407805.1  tubulin alpha-4A chain isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166150

  6. NM_009447.5 → NP_033473.1  tubulin alpha-4A chain isoform 1

    See identical proteins and their annotated locations for NP_033473.1

    Status: VALIDATED

    Source sequence(s)
    AC166150
    Consensus CDS
    CCDS35623.1
    UniProtKB/Swiss-Prot
    P68368, Q3TY31
    UniProtKB/TrEMBL
    Q3TIZ0
    Related
    ENSMUSP00000140657.2, ENSMUST00000186213.7
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 448
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75190867..75197905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496478.2 → XP_006496541.1  tubulin alpha-4A chain isoform X1

    See identical proteins and their annotated locations for XP_006496541.1

    UniProtKB/TrEMBL
    Q3TIZ0
    Conserved Domains (1) summary
    PTZ00335
    Location:1 → 433
    PTZ00335; tubulin alpha chain; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68368.1 GenPept UniProtKB/Swiss-Prot:P68368

Gene LinkOut

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